Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study

互联生活 - 通过同理心克服自我（关闭）：二元、多方法研究

• 批准号: 10376271
• 负责人: Jessica Renee Andrews-Hanna
• 金额: $ 63.26万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10376271
• 关键词: 3-Dimensional; Address; Adult; Affect; Anxiety; Area; Behavior; Behavioral; Brain; Couples; Data; Emotional; Emotional disorder; Emotions; Empathy; Feedback; Feeling; Functional Magnetic Resonance Imaging; Future; Goals; Health; Heart; Hostility; Impaired health; Impairment; Individual; Intervention; Life; Light; Link; Loneliness; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Mind; Modeling; Outcome; Participant; Partner in relationship; Patient Self-Report; Pattern; Personal Satisfaction; Psyche structure; Psychopathology; Questionnaires; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Sampling; Scientific Advances and Accomplishments; Services; Shapes; Social Behavior; Stress; Symptoms; Testing; Thinking; Time; Work; biopsychosocial factor; brain behavior; design; healthspan; improved; interest; member; middle age; mobile application; negative affect; neuroimaging; novel; primary outcome; prospective; relating to nervous system; smartphone Application; social; social factors; social integration; social relationships; statistics; trait; young adult

PROJECT SUMMARY This project seeks to shed light on mechanisms underlying transdiagnostic risk for mental illness by integrating two traditionally disparate lines of research. One line of work indicates that repetitive negative thinking (RNT)—a transdiagnostic risk factor characterized by frequent, negative, self-focused thoughts— increases vulnerability for a range of mental health disorders, including depression and anxiety. A second line of work demonstrates that high-quality social relationships are associated with lower rates of mental and physical illness; conversely, relationship stress, hostility, and disconnection exacerbate loneliness, isolation, and mental and physical illness. This proposal will test a new model in which RNT and social connectedness work together as parts of an integrated whole. The central argument of this model is that RNT exerts its pernicious effects on mental health by impairing the ability to meaningfully connect with others through empathy—a critical component of social connection that involves sharing and understanding others’ emotions. Critical to this model is the hypothesis that RNT and empathy operate dyadically; that is, they affect both partners in a close relationship. To test this model, this project will implement a multilevel research design that integrates self-report, neuroimaging, and naturalistic observation to study RNT, social connection, and mental health in the context of established close relationships. Specifically, the project will employ a multi-method approach across 200 established romantic couples (young adults to those in middle age; N = 400) to assess the following aims: (1) Examine associations between RNT and partner-directed neural and behavioral empathy among romantic couples; (2) Determine the role of neural empathy in dyadic social-emotional and mental health outcomes; (3) Determine the role of RNT in dyadic mental health outcomes; and (4) Examine whether neural empathy mediates the dyadic association between RNT and longitudinal mental health outcomes. Advancing prior work, the proposed research will examine neural empathy in a novel and validated social feedback task using functional MRI in each member of the couple, to be modelled using dyadic statistics. Additionally, RNT and daily social behaviors will be assessed in everyday life using two mobile apps developed by the research team: Mind Window and the Electronically Activated Recorder (EAR). Finally, mental health will be assessed over 6 months to allow for prospective changes in the primary outcomes of interest. To tackle the study’s aims, this proposal brings together an interdisciplinary team of researchers with expertise spanning all facets of the proposed research: RNT, depression, neural empathy, social connectedness, dyadic modelling, and ambulatory assessment. Ultimately, this work holds promise for advancing scientific understanding of how individual and social risks for psychopathology operate together to shape emotional disorders. In turn, this research has the potential to help identify novel intervention targets to strengthen social connectedness in service of improving mental health.

项目概要 该项目旨在通过以下方式揭示精神疾病跨诊断风险的机制： 整合两个传统上不同的研究领域，其中一项工作表明重复的负面结果。 思维（RNT）——一种跨诊断风险因素，其特征是频繁、消极、以自我为中心的想法—— 增加了一系列精神健康疾病的脆弱性，包括抑郁和焦虑。 的工作表明，高质量的社会关系与较低的心理和 身体疾病；相反，人际关系压力、敌意和疏离加剧了孤独、孤立、 该提案将测试 RNT 和社会联系的新模型。 该模型的核心论点是 RNT 发挥其作用。 通过削弱与他人进行有意义的联系的能力，对心理健康产生有害影响 同理心——社会联系的一个重要组成部分，涉及分享和理解他人的情绪。 该模型的关键是 RNT 和同理心相互作用的假设，即它们对两者都有影响。 为了测试这个模型，该项目将实施一个多层次的研究设计。 整合自我报告、神经影像学和自然观察来研究 RNT、社会联系和心理 具体来说，该项目将采用多种方法。 对 200 对已建立浪漫关系的情侣（年轻人到中年人；N = 400）进行评估 目标如下： (1) 检查 RNT 与伙伴导向的神经和行为之间的关联 (2) 确定神经共情在二元社会情感和情感关系中的作用 心理健康结果；(3) 确定 RNT 在二元心理健康结果中的作用；以及 (4) 检查 神经共情是否介导 RNT 与纵向心理健康之间的二元关联 为了推进之前的工作，拟议的研究将以新颖且经过验证的方式检验神经同理心。 使用功能 MRI 对夫妇的每个成员进行社会反馈任务，并使用二元模型进行建模 此外，将使用两个移动应用程序在日常生活中评估 RNT 和日常社交行为。 由研究团队开发：Mind Window 和电子激活记录器（EAR）。 将在 6 个月内对心理健康状况进行评估，以考虑到主要结果的前瞻性变化 为了实现该研究的目标，该提案汇集了一个跨学科的研究人员团队。 涵盖拟议研究各个方面的专业知识：RNT、抑郁症、神经共情、社交 最终，这项工作有望实现。 促进对个人和社会病理风险如何共同作用的科学心理学理解 反过来，这项研究有可能帮助确定新的干预目标。 加强社会联系，为改善心理健康服务。