Center for Cellular Metabolism Research in Oklahoma

俄克拉荷马州细胞代谢研究中心

• 批准号: 10090975
• 负责人: Lijun Xia
• 金额: $ 262.2万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090975
• 关键词: Address; Aging; Area; Arthritis; Autoimmune Diseases; Biological Models; Biology of Aging; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cells; Centers of Research Excellence; Clinical Immunology; Core Facility; Development; Diabetes Mellitus; Disease; Environment; Equipment; Faculty; Fostering; Foundations; Funding; Goals; Growth; Health; Human Resources; Infrastructure; Interdisciplinary Study; Leadership; Life; Malignant Neoplasms; Medical Research; Mentors; Metabolism; Oklahoma; Pathogenesis; Phase; Records; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Scientist; Secure; Training; Universities; Work; career; collaborative environment; environmental change; experience; interest; member; multidisciplinary; novel; professor; programs; recruit; repaired; success; tenure track

Altered cellular metabolism contributes to the pathogenesis of many common diseases, such as cardiovascular disease, cancer, diabetes, and autoimmune disorders, which are prevalent in Oklahoma. However, metabolism- related research resources and infrastructure are currently insufficient and scattered in Oklahoma. To address these deficiencies, this Center for Cellular Metabolism Research in Oklahoma (CMRO) Phase I COBRE will create and nurture excellence in cellular metabolism in Oklahoma. The CMRO is located at the Oklahoma Medical Research Foundation (OMRF), a leading biomedical research institute. The central focus of the CMRO is to support five new Assistant Member-level faculty (equivalent to tenure-track Assistant Professor at a Research University) as Project Leaders from three different OMRF Research Programs: Cardiovascular Biology (CVB), Aging & Metabolism (AM), and Arthritis & Clinical Immunology (ACI). These new junior investigators are the foundation for expansion and unification of cellular metabolism research. They will receive an appropriate level and form of multidisciplinary mentoring from experienced and competitive scientists. The CMRO COBRE aims to develop a critical mass of investigators who can secure external funding to support their research while creating a new, exciting, multidisciplinary, and collaborative environment for sustained competitive research on cellular metabolism in Oklahoma, which will be achieved through five Aims: 1) Support five promising young Project Leaders to scientific independence through incorporation of cellular metabolism research in their labs; 2) Promote novel multidisciplinary research focusing on cellular metabolism through mentoring the junior Project Leaders from three different OMRF Research Programs; 3) Integrate existing and new resources through Core facilities that support cellular metabolism research; 4) Promote an environment that supports the success and development of an independent sustainable center. The COBRE support will be critical to create a new, multidisciplinary and collaborative environment for sustained competitive research on cellular metabolism in Oklahoma.

细胞代谢改变有助于许多常见疾病的发病机理，例如心血管 俄克拉荷马州疾病，癌症，糖尿病和自身免疫性疾病。但是，新陈代谢 - 相关的研究资源和基础设施目前不足，俄克拉荷马州分散。解决 这些缺陷，这个俄克拉荷马州（CMRO）I期的细胞代谢研究中心将 在俄克拉荷马州创造和培养卓越的细胞代谢。 CMRO位于俄克拉荷马州 医学研究基金会（OMRF），领先的生物医学研究所。 CMRO的中心重点 将支持五个新的助理会员级教师（相当于Thenure-Track助理教授 研究大学）作为来自三个不同OMRF研究计划的项目负责人：心血管生物学 （CVB），衰老与代谢（AM）以及关节炎与临床免疫学（ACI）。这些新的初级调查人员是 扩展和统一细胞代谢研究的基础。他们会收到适当的 来自经验丰富和竞争科学家的多学科指导的水平和形式。 CMRO毛绒 旨在培养大量调查人员，他们可以确保外部资金以支持他们的研究 创建一个新的，令人兴奋的，多学科和协作的环境，以持续的竞争研究 俄克拉荷马州的细胞代谢将通过五个目标实现：1）支持五个有希望的年轻人 通过将细胞代谢研究纳入实验室的项目领导者来实现科学独立性； 2） 通过指导初级项目，促进新颖的多学科研究，重点是细胞代谢 来自三个不同OMRF研究计划的领导者； 3）通过核心整合现有和新资源 支持细胞代谢研究的设施； 4）促进一个支持成功的环境和 开发独立的可持续中心。工土支持对于创建一个新的， 多学科和协作环境，用于持续有关细胞代谢的竞争性研究 俄克拉荷马州。