Center for Cellular Metabolism Research in Oklahoma

俄克拉荷马州细胞代谢研究中心

• 批准号: 10090975
• 负责人: Lijun Xia
• 金额: $ 262.2万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10090975
• 关键词: Address; Aging; Area; Arthritis; Autoimmune Diseases; Biological Models; Biology of Aging; Biomedical Research; Cardiovascular Diseases; Cardiovascular system; Cells; Centers of Research Excellence; Clinical Immunology; Core Facility; Development; Diabetes Mellitus; Disease; Environment; Equipment; Faculty; Fostering; Foundations; Funding; Goals; Growth; Health; Human Resources; Infrastructure; Interdisciplinary Study; Leadership; Life; Malignant Neoplasms; Medical Research; Mentors; Metabolism; Oklahoma; Pathogenesis; Phase; Records; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Scientist; Secure; Training; Universities; Work; career; collaborative environment; environmental change; experience; interest; member; multidisciplinary; novel; professor; programs; recruit; repaired; success; tenure track

Altered cellular metabolism contributes to the pathogenesis of many common diseases, such as cardiovascular disease, cancer, diabetes, and autoimmune disorders, which are prevalent in Oklahoma. However, metabolism- related research resources and infrastructure are currently insufficient and scattered in Oklahoma. To address these deficiencies, this Center for Cellular Metabolism Research in Oklahoma (CMRO) Phase I COBRE will create and nurture excellence in cellular metabolism in Oklahoma. The CMRO is located at the Oklahoma Medical Research Foundation (OMRF), a leading biomedical research institute. The central focus of the CMRO is to support five new Assistant Member-level faculty (equivalent to tenure-track Assistant Professor at a Research University) as Project Leaders from three different OMRF Research Programs: Cardiovascular Biology (CVB), Aging & Metabolism (AM), and Arthritis & Clinical Immunology (ACI). These new junior investigators are the foundation for expansion and unification of cellular metabolism research. They will receive an appropriate level and form of multidisciplinary mentoring from experienced and competitive scientists. The CMRO COBRE aims to develop a critical mass of investigators who can secure external funding to support their research while creating a new, exciting, multidisciplinary, and collaborative environment for sustained competitive research on cellular metabolism in Oklahoma, which will be achieved through five Aims: 1) Support five promising young Project Leaders to scientific independence through incorporation of cellular metabolism research in their labs; 2) Promote novel multidisciplinary research focusing on cellular metabolism through mentoring the junior Project Leaders from three different OMRF Research Programs; 3) Integrate existing and new resources through Core facilities that support cellular metabolism research; 4) Promote an environment that supports the success and development of an independent sustainable center. The COBRE support will be critical to create a new, multidisciplinary and collaborative environment for sustained competitive research on cellular metabolism in Oklahoma.

细胞代谢的改变导致许多常见疾病的发病机制，例如心血管疾病 疾病、癌症、糖尿病和自身免疫性疾病，这些疾病在俄克拉荷马州很普遍。然而，新陈代谢—— 目前俄克拉荷马州相关研究资源和基础设施不足且分散。致地址 针对这些缺陷，俄克拉荷马州细胞代谢研究中心 (CMRO) I 期 COBRE 将 在俄克拉荷马州创造和培育卓越的细胞代谢。 CMRO 位于俄克拉荷马州 医学研究基金会 (OMRF)，一家领先的生物医学研究机构。 CMRO 的核心焦点 是支持五名新的助理会员级教师（相当于某大学的终身教授助理教授） 研究大学）作为三个不同 OMRF 研究项目的项目负责人：心血管生物学 （CVB）、衰老与代谢（AM）以及关节炎与临床免疫学（ACI）。这些新的初级调查员是 细胞代谢研究的扩展和统一的基础。他们将获得适当的 来自经验丰富且有竞争力的科学家的多学科指导的水平和形式。 CMRO COBRE 旨在培养足够数量的研究人员，他们能够获得外部资金来支持他们的研究，同时 为持续的竞争性研究创造一个新的、令人兴奋的、多学科的协作环境 俄克拉荷马州的细胞代谢，这将通过五个目标来实现：1）支持五名有前途的年轻人 项目负责人通过将细胞代谢研究纳入实验室来实现科学独立； 2） 通过指导初级项目促进以细胞代谢为重点的新型多学科研究 来自三个不同 OMRF 研究项目的领导者； 3）通过Core整合现有资源和新资源 支持细胞代谢研究的设施； 4) 营造一个支持成功的环境 发展一个独立的可持续中心。 COBRE 的支持对于创建一个新的、 多学科和协作环境，用于细胞代谢的持续竞争性研究 俄克拉荷马州。