Epigenetic mechanisms regulating neuron production during cortical development

皮质发育过程中调节神经元产生的表观遗传机制

基本信息

批准号：
10259827
负责人：
Louis-Jan Pilaz
金额：
$ 46.37万
依托单位：
SANFORD RESEARCH/USD
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10259827
关键词：
Advisory Committees Animal Model Applications Grants Basic Science Biochemical Biochemistry Bioinformatics Caring Cell Proliferation Cell physiology Cells Cellular biology Centers of Research Excellence Cessation of life Child Child Development Child Health Childhood Clinic Clinical Clinical Research Communities Complement Core Facility Data Development Developmental Biology Developmental Process Diagnosis Disease Effectiveness Environment Epigenetic Process Evaluation Fostering Foundations Funding Genetic Genetic Diseases Goals Growth and Development function Health Healthcare Systems Human Biology Human Development Image Institution Interdisciplinary Study K-12 student Leadership Learning Medical Students Medicine Mentors Mentorship Mind Modeling Molecular Molecular Biology Morphogenesis Neurons Pediatric Hospitals Pediatric Research Phase Physicians Plant Roots Postdoctoral Fellow Production Regulation Research Research Activity Research Personnel Research Project Grants Research Training Resources Role Rural Science Scientist Sioux Falls South Dakota Technical Expertise Training Translational Research United States United States National Institutes of Health base collaborative environment data submission experience fetal programming functional genomics graduate student human disease improved innovation learning community medical specialties member migration multidisciplinary northern plains outreach pressure recruit skills success supportive environment training opportunity translational study undergraduate student

项目摘要

The primary goal of this application is to establish a foundation of basic scientists with translational research projects studying developmental mechanisms underlying children’s disease by establishing the Center for Pediatric Research. The origin of many pediatric diseases is from altered developmental programming related to the processes of cell proliferation, morphogenesis, migration, differentiation, and programmed death. These developmental processes are at the root of pediatric disease and are disrupted through genetic disorders, aberrant fetal programming, altered growth & development, and environmental pressures. Our multidisciplinary Center applies genetic, biochemical, cell, and molecular approaches across several model organisms to characterize alterations during development as they pertain to pediatric diseases and disorders. For phase II we will continue to build upon the success of phase I efforts to create a critical mass of independently funded investigators within the Center for Pediatric Research by refining our focus to support and mentor junior investigators whose research investigates how key regulators of cellular pliancy contribute to the developmental origin of pediatric disorders. Center success will be achieved through the following Aims: 1) create a supportive environment for the training and mentorship of scientists studying how regulation of cell pliancy contributes to pediatric diseases; 2) utilize and enhance existing resources that will enable pediatric research; 3) expand training and learning opportunities in developmental biology and pediatric disease; and 4) evaluate success of the Center. Through these Aims, the Center for Pediatric Research will develop a strong foundation in basic and translational research by fostering a collaborative environment for scientists and physicians. Strengthened by our institution’s strong commitment to children’s medicine, we propose that the Center will continue to enhance pediatric research efforts in South Dakota.

该应用的主要目标是建立翻译的基础科学家的基础通过建立该中心的项目，研究儿童疾病潜在的发展机制的项目小儿研究的起源。对于细胞泛滥，形态发生，迁移，区分和程序性死亡的过程。发育过程是小儿疾病的根源，并因遗传疾病而破坏，胎儿编程，增长与发展改变以及我们的多学科中央在Severos模型生物体上应用遗传，生化，细胞和分子在发育过程中的变化是与小儿疾病有关的我们将继续基于第一阶段敌方的成功，以创建大量的独立资助小儿研究中心的调查人员通过完善我们的重点来支持和指导初级研究人员的研究调查了细胞层流的关键调节因子如何贡献小儿疾病的发展起源。为研究细胞调节的培训和指导创造支持环境平衡有助于儿科疾病； 2）研究； 3）扩大发育生物学和小儿疾病的学习机会；通过这些目标评估中心的成功。通过为科学家培养协作环境，基础研究和转化研究的基础医生。中央将继续增强南达科他州的儿科研究恩惠。