Neuroimaging of the Development of Neural Mechanisms for Number Processing

数字处理神经机制发展的神经影像学

• 批准号: 7905059
• 负责人: Kevin A Pelphrey
• 金额: $ 29.93万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-10 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905059
• 关键词: 4 year old; 5 year old; 7 year old; 8 year old; Academic achievement; Achievement; Address; Adult; Animals; Biological; Brain; Brain region; Child; Childhood; Cognition; Color; Comparative Study; Data; Dependency; Development; Disease; Educational Curriculum; Educational Intervention; Exhibits; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Human; Image; Impairment; Individual Differences; Infant; Inferior; Intelligence; Laboratories; Lead; Learning; Link; Lobule; Longitudinal Studies; Magnetic Resonance Imaging; Mathematics; Measures; Neurobiology; Numerical value; Parietal; Parietal Lobe; Pattern; Perception; Process; Reading; Recruitment Activity; Research; Research Design; Risk; Sampling; Scanning; Shapes; Staging; Structure; Sum; Visual; Work; angular gyrus; base; behavior measurement; design; early childhood; intervention program; intraparietal sulcus; mathematical ability; mathematics disability; neural circuit; neurodevelopment; neuroimaging; neuromechanism; novel; programs; relating to nervous system; remediation; spelling; standardize measure

DESCRIPTION (provided by applicant): The non-verbal numerical abilities identified in non-human animals as well as human infants and young children are hypothesized to represent biological and developmental precursors of adult humans' more sophisticated numerical and mathematical abilities. Information regarding the neural basis for the processing of number during childhood may therefore prove critical to our understanding of individual differences in mathematical abilities, including such disorders of mathematical abilities as acalculia and developmental dyscalculia. Numerical cognition and the perception of numerosity have been linked via functional neuroimaging studies of adults to activity in regions of parietal cortex including the inferior and superior parietal lobules, the angular gyri, and the horizontal segment of the intraparietal sulci. However, little is known about the neural correlates of number processing in children or about the changes in brain function that support the development of numerosity perception and numerical cognition during childhood. Likewise, the neurobiological basis of individual differences in mathematical abilities in children and adults remains poorly understood. The overarching goal of the proposed research is to characterize, using functional magnetic resonance imaging (fMRI), the patterns of change in brain activity associated with developmental changes in aspects of number perception and numerical cognition during early childhood. An additional goal is to identify potential correlations between individual differences in mathematical abilities and individual differences in patterns of developmental change in brain activity. By evaluating how the neural circuitry supporting number processing normally develops over the 4- to 8-year-old period, and how it differs from or is similar to that of adults, the proposed research will begin to explore systematically the longitudinal development and neural bases for the representation and manipulation of number. This project will set the stage for comparative studies of children with impairments in mathematical abilities. Moreover, this work will provide a methodological foundation for future work aimed at evaluating the neural mechanisms underlying successful educational interventions for remediation of deficits in mathematical abilities in children. Consistent with these goals, we will analyze the longitudinal fMRI data and laboratory and standardized measures of number processing and mathematics achievement to identify potential neural predictors of individual differences in math abilities in the children we scan. This research will inform our basic understand of how changes in the brain relate to developmental changes in the ways in which children perceive and think about numbers. This basic understanding, in turn, might inform our understanding of individual differences in math abilities. This program of research could eventually lead to improvements in math curriculum and intervention programs for children at risk for developing difficulties in learning math.This research will inform our basic understand of how changes in the brain relate to developmental changes in the ways in which children perceive and think about numbers. This basic understanding, in turn, will inform our understanding of individual differences in math abilities. This program of research could eventually lead to improvements in math curriculum and intervention programs for children at risk for developing difficulties in learning math.

描述（由申请人提供）：假设在非人类动物以及人类婴儿和幼儿中发现的非语言数字能力代表了成年人更复杂的数字和数学能力的生物和发育前兆。因此，有关童年时期数字处理的神经基础的信息可能对我们理解数学能力的个体差异至关重要，包括诸如计算障碍和发育性计算障碍等数学能力障碍。通过成人的功能性神经影像学研究，数字认知和数字感知与顶叶皮质区域的活动联系起来，包括顶下小叶和顶上小叶、角回和顶内沟水平段。然而，人们对儿童数字处理的神经相关性或支持儿童时期数字感知和数字认知发展的大脑功能变化知之甚少。同样，儿童和成人数学能力个体差异的神经生物学基础仍然知之甚少。该研究的总体目标是利用功能磁共振成像（fMRI）来表征与幼儿期数字感知和数字认知方面的发育变化相关的大脑活动变化模式。另一个目标是确定数学能力的个体差异与大脑活动发育变化模式的个体差异之间的潜在相关性。通过评估支持数字处理的神经回路在4至8岁期间如何正常发育，以及它与成人的不同或相似之处，拟议的研究将开始系统地探索纵向发育和神经基础用于数字的表示和操作。该项目将为数学能力障碍儿童的比较研究奠定基础。此外，这项工作将为未来的工作提供方法论基础，旨在评估成功的教育干预措施的神经机制，以纠正儿童数学能力的缺陷。与这些目标一致，我们将分析纵向功能磁共振成像数据以及数字处理和数学成绩的实验室和标准化测量，以确定我们扫描的儿童数学能力个体差异的潜在神经预测因素。这项研究将帮助我们基本了解大脑的变化如何与儿童感知和思考数字的方式的发展变化相关。这种基本的理解反过来可能会帮助我们理解数学能力的个体差异。这项研究计划最终可能会改进数学课程，并为有数学学习困难风险的儿童提供干预计划。这项研究将帮助我们基本了解大脑的变化如何与儿童感知方式的发展变化相关。并思考数字。这种基本的理解反过来将有助于我们理解数学能力的个体差异。这项研究计划最终可能会改进数学课程，并为有数学学习困难风险的儿童提供干预计划。