True Metal fac core

真正的金属面芯

• 批准号: 9257403
• 负责人: Regina M Santella
• 金额: $ 18.76万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9257403
• 关键词: Adverse effects; Animal Model; Arsenic; Award; Biochemical; Biological; Cadmium; Cells; Chromium; Chronic Disease; Cobalt; Consult; Copper; Core Facility; Data Analyses; Department chair; Elements; Environmental Health; Exposure to; Faculty; Funding; Funding Agency; Gambling; Grant; Health; Health Hazards; Heavy Metals; International; Iron; Laboratories; Lead; Learning; Life; Liquid substance; Literature; Manganese; Manuscripts; Measurement; Mercury; Metals; Methods; Minerals; Organ; Outcome; Physiological; Platinum; Potassium; Preparation; Public Health; Quality Control; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Sampling; Sodium; Standardization; Superfund; System; Time; Toxic effect; Trace metal; United States National Institutes of Health; Work; Zinc; biomedical scientist; career; cost effective; data management; early life exposure; human population study; interest; member; metal poisoning; method development; neurotoxic; programs; ranpirnase; sample collection; tissue culture

A.2. Objectives: Numerous investigators have a need for the analysis of trace metals to conduct their research in environmental health sciences. The objective of the Trace Metals Core Lab is to enable these investigators to obtain the required measurements of metals in biological samples in a scientifically valid and cost-effective manner. During the past grant cycle, numerous NIH Grant awards to CEHNM investigators assure that the Trace Metals Facility Core will continue to be a critically important analytical laboratory. New NIH awards to Drs. Ahsan [3 R01s], Barr, Gamble [2 R01s], Graziano (Superfund/3 projects), and Guilarte [3 R01s], and Louis all require assistance from this Core Lab. In particular, the recruitment in 2010 of Dr. Tomas Guilarte as the EHS Department Chair - whose research career has focused on the neurotoxic effects of Pb and Mn - has added new NlEHS-funded research projects that require trace metal laboratory support. This Core Laboratory provides method development for these metal analyses, standardization, and quality control. Biochemical analyses that help in the assessment ofthe physiological status ofthe subjects that are exposed to these metals are also conducted. We should note here that this laboratory is partially funded by our Superfund Research Program (SRP), which was recently renewed. The SRP funds roughly two-thirds of this laboratory; the R01 grant work is not supported by the SRP grant and requires P30 Center support. The two sources of funding are directly proportionate with the use ofthe Core by the two programs.

A.2。目标：许多研究人员需要分析痕量金属，以在环境健康科学领域进行研究。痕量金属核心实验室的目的是使这些研究者能够以科学有效且具有成本效益的方式获得生物样品中金属的所需测量。在过去的赠款周期中，向CEHNM调查人员提供了许多NIH赠款奖励，保证Trace Metals设施核心将继续是至关重要的分析实验室。新的NIH颁发给博士。 Ahsan [3 R01S]，Barr，Gamble [2 R01S]，Graziano（SuperFund/3 Projects）和Guilarte [3 R01S]，路易斯都需要此核心实验室的帮助。特别是，2010年托马斯·吉拉尔特（Tomas Guilarte）博士担任EHS部门主席 - 其研究职业集中在PB和MN的神经毒性影响上 - 增加了新的NLEHS资助的研究项目，需要痕量金属实验室支持。 该核心实验室为这些金属分析，标准化和质量控制提供了方法开发。还进行了暴露于这些金属的受试者的生理状态的生化分析。我们应该在这里注意到，该实验室由我们的超级基金研究计划（SRP）部分资助，该计划最近续签了。 SRP资助了该实验室的三分之二； R01赠款工作不受SRP赠款的支持，需要P30中心支持。这两个资金来源与两个程序对核心的使用成正比。