Nested Study: Identifying Risk for Diabetes and Heart Disease in Women: A Study of African-American, African and White Federal Employees and Contractors

嵌套研究：识别女性糖尿病和心脏病的风险：针对非裔美国人、非洲人和白人联邦雇员和承包商的研究

• 批准号: 10250256
• 负责人: Stephanie Therese Chung
• 金额: $ 6.31万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10250256
• 关键词: Accounting; Adipose tissue; African; African American; Age; Biological; Blood Circulation; Blood Glucose; Body fat; Clinical Endocrinology; Complex; Contractor; Detection; Development; Diabetes Mellitus; Diet; Disease; Employee; Endocrinology; Energy Metabolism; Ethnic Origin; Evaluation; Fasting; Fatty acid glycerol esters; Gluconeogenesis; Glucose; Heart Diseases; Hepatic; Hyperglycemia; Insulin; Insulin Resistance; Insulin Resistance Pathway; Journals; Life Style; Liver; Low Prevalence; Manuscripts; Measures; Metabolism; Non-Insulin-Dependent Diabetes Mellitus; Peer Review; Physical activity; Physiological; Population; Prediabetes syndrome; Premenopause; Preparation; Protocols documentation; Psychosocial Factor; Publishing; Race; Research; Resources; Risk Factors; Screening procedure; Testing; Tissues; Triglycerides; Variant; Woman; cardiometabolic risk; design; diabetes risk; epidemiology study; ethnic difference; fasting glucose; glucose metabolism; glucose production; glycogenolysis; health care availability; insight; lipid metabolism; low socioeconomic status; novel; screening

The Federal Women nested study was designed to help unravel the complex association of race/ ethnicity, hepatic insulin resistance and the pathway to diabetes. This project evaluated the components of hepatic glucose production (gluconeogenesis and glycogenolysis) and the contribution of hepatic to total body insulin resistance by race and ethnicity. Eligible women (30 African descent and 30 white) who participated in theprimary protocol (13-DK-0090) were invited to participate in the nested study to measure glucose and fat metabolism and energy expenditure. In 46 pre-menopausal federally-employed women, without diabetes: 24 black and 22 white; age 371 (meanSEM), range 25-49 y; BMI 321, range 24-45 kg/m2 we found lower gluconeogenesis (new glucose made by the liver) despite similar rates of whole-body insulin resistance and prediabetes. In addition, there was less insulin resistance in the liver in black women but no difference in insulin resistance in adipose (fat) tissue. These findings provided mechanistic insight to help understand why the fasting blood glucose test has lower sensitivity for detecting prediabetes/ diabetes in black women. Our findings have been published in major peer-review journals (The Journal JCI Insight and The Journal of Clinical Endocrinology and Metabolism, Circulation Research) and a 4th manuscript is in preparation.

联邦妇女嵌套的研究旨在帮助揭开种族/种族，肝胰岛素抵抗和糖尿病途径的复杂关联。该项目评估了肝葡萄糖产生的成分（糖异生和糖原分解），并评估了种族和种族对全身胰岛素耐药性的贡献。邀请参加主要方案（13-DK-0090）的合格妇女（30名非洲血统和30名白人）参加嵌套研究，以衡量葡萄糖和脂肪代谢和能量消耗。在46名未经糖尿病的联邦政府妇女中，有24名黑人和22名白色；年龄371（ememem），范围25-49 y； BMI 321，范围24-45 kg/m2，尽管全身胰岛素抵抗和前糖尿病率相似，但我们发现较低的糖异生（肝脏制造的新葡萄糖）。 此外，黑人女性的肝脏耐药性较小，但脂肪（脂肪）组织中的胰岛素抵抗没有差异。这些发现提供了机械洞察力，以帮助理解为什么禁食血糖测试对检测黑人妇女的糖尿病/糖尿病的灵敏度较低。我们的发现已发表在主要的同行评审期刊上（JCI Insight和《临床内分泌与代谢杂志》，流通研究），并准备了第四次手稿。