Community-based, client-centered prevention homes to address the rural opioid epidemic

以社区为基础、以客户为中心的预防之家，解决农村阿片类药物流行问题

• 批准号: 10241935
• 负责人: David W Seal
• 金额: $ 78.82万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241935
• 关键词: Acquired Immunodeficiency Syndrome; Address; Affect; Antiviral Agents; Area; Case Management; Case Manager; Characteristics; Client; Clinical; Collaborations; Communicable Diseases; Communities; County; Data; Data Collection; Epidemic; Epidemiology; Evaluation; Geography; Goals; HIV; HIV/HCV; Harm Reduction; Health Information System; Health Service Area; Health Services; Hepatitis C virus; Heroin; Home; Individual; Infection; Infrastructure; Injecting drug user; Intervention; Legal; Medical; Methods; Mobile Health Application; Modeling; Names; Needle-Exchange Programs; Needs Assessment; Opiate Addiction; Opioid; Pharmaceutical Preparations; Phase; Population; Population Surveillance; Prevalence; Prevention; Program Effectiveness; Provider; Public Health; Quantitative Evaluations; Questionnaires; Research; Resources; Respondent; Risk; Rural; Rural Community; Rural Population; Sampling; Service delivery model; Services; Sexually Transmitted Diseases; Site; Source; Syringes; System; Testing; Time; Translating; United States; Viral hepatitis; Wisconsin; World Health Organization; base; comorbidity; ethnographic method; evidence base; experience; geographic inaccessibility; health information technology; high risk; implementation framework; implementation science; innovation; mHealth; marginalized population; medication-assisted treatment; meetings; novel; opioid abuse; opioid abuse prevention; opioid epidemic; opioid injection; opioid mortality; opioid use disorder; opioid user; person centered; prescription opioid abuse; prevent; prevention service; preventive intervention; public health relevance; recruit; response; rural counties; rural dwellers; rural residence; service coordination; service delivery; success; treatment services; trend; uptake

PROJECT SUMMARY In response to RFA-DA-17-014, HIV, HCV and Related Comorbidities in Rural Communities Affected by Opioid Injection Drug Epidemics in the United States: Building Systems for Prevention, Treatment and Control (UG3/UH3), we propose a multi-phase, mixed-methods study that aims to implement and evaluate a novel community response model, which we have named the Community-Based, Client-Centered Prevention Home. Using the organizational infrastructure of a large, multi-site syringe service program serving a geographically disperse population of people who inject drugs in rural communities across Northern Wisconsin, we will build locally responsive systems to facilitate uptake of evidence-based prevention services for high-risk clients. The Client-Centered Prevention Home model incorporates prevention case management and mobile health information technology into traditional harm-reduction services delivered at syringe service programs, which we hypothesize will increase use prevention services. During the UG3 phase, we will perform needs assessments in 6 rural Wisconsin counties in partnership with local stakeholders, and use respondent driven sampling to conduct a cross-sectional epidemiologic evaluation to estimate the prevalence of HIV, viral hepatitis and sexually transmitted infections. Contingent upon meeting recruitment and data collection goals, in the UH3 phase of the project we will deploy and evaluate the Client-Centered Prevention Home model in the 3 counties demonstrating highest vulnerability to worsening epidemics of opioid injection. The 3 remaining counties not selected for implementation will serve as comparison sites in a quantitative evaluation of program effectiveness during year 5. The growing problem of opioid injection in rural Wisconsin is highly significant because it exemplifies trends observed nationally indicating severe vulnerability to worsening epidemics of HIV, HCV, and opioid overdose deaths in rural communities that are substantially underserved by evidence-based prevention interventions. This proposal is highly innovative because it will be the first study to use an evidence-based mHealth strategy and a formal implementation science approach to enhance coordination of prevention services in syringe service programs. It has potential for high impact because of our team's state-wide reach, broad access to at-risk individuals, and robust infrastructure for conducting a rigorous, multi-site evaluation of our proposed model.

项目摘要 为了回应RFA-DA-17-014，HIV，HCV及其相关合并症，受阿片类药物影响的农村社区 美国注射药物流行病：预防，治疗和控制的建筑系统 （UG3/UH3），我们提出了一项多相的混合方法研究，旨在实施和评估一种新颖 社区响应模型，我们将其命名为基于社区的，以客户为中心的预防房屋。 使用一个大型多站点注射器服务计划的组织基础架构，该计划在地理上服务 分散在威斯康星州北部的农村社区注入毒品的人群，我们将建造 本地响应式系统，可促进为高风险客户提供基于证据的预防服务。这 以客户为中心的预防家庭模型结合了预防案例管理和移动健康 在注射器服务计划中提供的信息技术中的传统损害减少服务，我们 假设将增加使用预防服务。在UG3阶段，我们将执行需求评估 在威斯康星州的6个农村县与当地利益相关者合作，并使用受访者驱动的抽样 进行横断面流行病学评估，以估计HIV，病毒肝炎和 性传播感染。在满足招聘和数据收集目标的情况下，在UH3中 该项目的阶段我们将在3个县中部署和评估以客户为中心的预防家庭模型 表现出最大的脆弱性，使阿片类药物注射的流行病恶化。剩下的3个县不 选择进行实施将作为对程序有效性的定量评估的比较站点 在第五年。威斯康星州农村地区阿片类药物注入的日益严重，因为它 举例说明了全国观察到的趋势，表明严重的脆弱性会使HIV，HCV和 农村社区的阿片类药物过量死亡，这些死亡人数基于证据的预防基本上是服务不足的 干预措施。该提案具有很高的创新性，因为它将是第一个使用基于证据的研究 MHealth战略和正式的实施科学方法来增强预防协调 注射器服务计划中的服务。由于我们团队在全州范围内，它具有高影响力的潜力， 广泛访问高危个人，以及强大的基础设施，以进行严格的多站点评估 我们提出的模型。

项目成果

Validation of Dried Blood Spots for Capturing Hepatitis C Virus Diversity for Genomic Surveillance.

验证干血斑捕获丙型肝炎病毒多样性以进行基因组监测。

• DOI: 10.1101/2023.07.06.23292160
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Tully,DamienC;Power,KarenA;Sarette,Jacklyn;Stopka,ThomasJ;Friedmann,PeterD;Korthuis,PTodd;Cooper,Hannah;Young,AprilM;Seal,DavidW;Westergaard,RyanP;Allen,ToddM
• 通讯作者: Allen,ToddM

Predictors of skin and soft tissue infections among sample of rural residents who inject drugs.

• DOI: 10.1186/s12954-020-00447-3
• 发表时间: 2020-12-02
• 期刊: Harm reduction journal
• 影响因子: 4.4
• 作者: Baltes A;Akhtar W;Birstler J;Olson-Streed H;Eagen K;Seal D;Westergaard R;Brown R
• 通讯作者: Brown R