Integrative Training in Oncogenic Signaling

致癌信号综合培训

• 批准号: 10267821
• 负责人: Philip H Howe
• 金额: $ 42.06万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-08 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267821
• 关键词: Oncogenic; Signal Transduction; Training

PROJECT SUMMARY/ABSTRACT This first renewal application seeks continued National Cancer Institute (NCI) support for a successful ‘Integrative Training in Oncogenic Signaling’ (ITOS) Program developed to train postdoctoral fellows by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The programtakes place in an active and growing medical center with state -of-the-art facilities,a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Directorship team with an exceptionally strong cancer research and leadership background, the ITOS Program selects and supports the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee has a primary mentor and one/two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that enhances the overall cancer-relatedresearch training experience. The objectives of the ITOS Programremain unchanged, seeking to provideproactive mentoring, oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and, to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevent, diagnosis, and treat cancer. The ITOS Program has seven essential programmatic components: 1) 33 member Program Faculty who share common cancer research interests and provide essential mentoring for trainees; 2) one to two year experiences in designated Program Faculty laboratories; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries; 4) shared research resource workshops and tailored training in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that equip trainees for independent success; and, 7) opportunities to network nationally at a minimum of two professional conferences each year. In its fourth year, the ITOS Program has graduated 9 fellows; 1MD, 1MD/PhD, 7 PhDs. Trainees from diverse backgrounds, 58% female and 30.8% underrepresented racial/ethnic minorities, whom have all successfully transitioned to positions in academia or industry. Based on the capabilities, capacity, trajectory of MUSC for cancer-related training, and the successful accomplishments achieved during its initial funding period, the ITOS Program is requesting the support for seven postdoctoral trainees each year, representing an increase of two trainee positions. In summary, our ITOS Program offers distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to remain highly attractive to emerging junior investigators locally and nationally.

项目概要/摘要 第一个续签申请寻求美国国家癌症研究所 (NCI) 的持续支持，以成功实现“综合治疗” 致癌信号培训（ITOS）计划旨在培训博士后研究员，由一组选定的人员开发 南卡罗来纳医科大学霍林斯癌症中心 (HCC) 的癌症科学家 （MUSC）该项目在一个活跃且不断发展的医疗中心进行，该中心拥有最先进的设施，充满活力。 NCI 指定的癌症中心，以及由项目主管团队领导的活跃的博士后事务办公室。 凭借极其强大的癌症研究和领导背景，ITOS 计划选择并 支持将学员安置在由该计划领导的经验丰富、资金充足、高效的实验室 教师们生活在一个互动的、多部门的研究环境中，每个人都拥有丰富的资源。 受训者有一名主要导师和一/两名具有互补专业知识的二级导师，以确保独特的培训 以及增强整体癌症相关研究培训经验的宝贵观点。 ITOS 计划的内容保持不变，寻求提供主动的指导、监督和研究培训 掌握前沿的方法论；培养有用的学术和基本的职业发展技能； 与教师和其他学员进行协作、跨学科互动；并提供对当前情况的接触； 癌症研究发现以及如何将这些发现转化为预防、诊断、 ITOS 计划有七个重要的计划组成部分：1) 33 个成员计划。 具有共同癌症研究兴趣并为学员提供必要指导的教师 2) 一对一； 指定项目教师实验室的两年经验；3) ITOS 项目研究俱乐部提供 一个供学员和项目教师参与的社区论坛，讨论正在进行的工作以及 最新发现；4）共享研究资源研讨会和尖端生物技术定制培训； 5) 与受训者一起参加 HCC 主办的主题研究静修会、研讨会、工作 进度会议和研讨会；6) 为学员​​提供职业发展研讨会和课程 独立的成功；7) 在至少两次专业会议上建立全国网络的机会 每年，ITOS 项目都会有 9 名研究员、1 名医学博士/博士、7 名博士生毕业。 背景多样化，其中 58% 为女性，30.8% 为代表性不足的种族/族裔，他们都拥有 根据能力、能力、轨迹成功过渡到学术界或工业界的职位。 MUSC 进行癌症相关培训，以及在其初始资助期间取得的成功成就， ITOS项目每年请求支持七名博士后培训生，这意味着增加 总而言之，我们的 ITOS 计划仅提供独特的经验和机会。 该项目由优秀的项目教员骨干领导，提供给选定的 ITOS 研究员 预计对当地和全国的新兴初级研究人员仍然具有高度吸引力。