Integrative Training in Oncogenic Signaling

致癌信号综合培训

基本信息

批准号：
10650782
负责人：
Philip H Howe
金额：
$ 32.7万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-08 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10650782
关键词：
Oncogenic Signal Transduction Training

项目摘要

PROJECT SUMMARY/ABSTRACT This first renewal application seeks continued National Cancer Institute (NCI) support for a successful ‘Integrative Training in Oncogenic Signaling’ (ITOS) Program developed to train postdoctoral fellows by a select group of cancer scientists affiliated with the Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC). The programtakes place in an active and growing medical center with state -of-the-art facilities,a vibrant NCI-designated cancer center, and an active Office of Postdoctoral Affairs. Led by a Program Directorship team with an exceptionally strong cancer research and leadership background, the ITOS Program selects and supports the placement of trainees in experienced, well-funded, productive laboratories led by the Program Faculty who reside in an interactive, multi-departmental research environment with extensive resources. Each trainee has a primary mentor and one/two secondary mentors with complementary expertise to ensure distinct and valuable perspectives that enhances the overall cancer-relatedresearch training experience. The objectives of the ITOS Programremain unchanged, seeking to provideproactive mentoring, oversight and research training in cutting-edge methodology; to develop useful academic and essential career development skills; to foster collaborative, interdisciplinary interactions with faculty and other trainees; and, to provide exposure to current cancer research discoveries and how these are being translated into novel approaches to prevent, diagnosis, and treat cancer. The ITOS Program has seven essential programmatic components: 1) 33 member Program Faculty who share common cancer research interests and provide essential mentoring for trainees; 2) one to two year experiences in designated Program Faculty laboratories; 3) an ITOS Program Research Club providing an engaging community forum for the trainees and Program Faculty to discuss work in progress as well as the latest discoveries; 4) shared research resource workshops and tailored training in cutting-edge biotechnologies; 5) interdisciplinary engagement with trainees in HCC-sponsored thematic research retreats, symposia, work in progress meetings, and seminars; 6) career development workshops and courses that equip trainees for independent success; and, 7) opportunities to network nationally at a minimum of two professional conferences each year. In its fourth year, the ITOS Program has graduated 9 fellows; 1MD, 1MD/PhD, 7 PhDs. Trainees from diverse backgrounds, 58% female and 30.8% underrepresented racial/ethnic minorities, whom have all successfully transitioned to positions in academia or industry. Based on the capabilities, capacity, trajectory of MUSC for cancer-related training, and the successful accomplishments achieved during its initial funding period, the ITOS Program is requesting the support for seven postdoctoral trainees each year, representing an increase of two trainee positions. In summary, our ITOS Program offers distinct experiences and opportunities only afforded to the selected ITOS Fellows, and the program, led by an outstanding cadre of Program Faculty, is anticipated to remain highly attractive to emerging junior investigators locally and nationally.

项目摘要/摘要第一次续签申请寻求持续国家癌症研究所（NCI）支持成功的综合性培训致癌信号传导（ITOS）计划，开发了培训一组的训练博士后研究员南卡罗来纳州医科大学Hollings Cancer Center（HCC）的癌症科学家会员（MUSC）。该编程将其放置在一个活跃而发展中的医疗中心，该中心是一个充满活力的国家的设施 NCI指定的癌症中心和博士后事务的积极办公室。由计划董事团队领导 ITOS计划以异常强大的癌症研究和领导背景，选择和支持受训者在经验丰富，资金丰富，有生产力的实验室中的安置居住在具有广泛资源的互动，多部门研究环境中的教师。每个受训者拥有具有完整专业知识的主要心理和一两种次要概念，以确保独特以及有价值的观点，可以增强整体癌症相关研究经验。目标 ITOS ProgrameRemain不变，试图提供心理，监督和研究培训在尖端的方法论中；发展有用的学术和基本职业发展技能；养育与教师和其他培训的合作，跨学科的互动；并且，以提供当前的暴露癌症研究发现，以及如何将它们转化为预防，诊断的新方法和治疗癌症。 ITOS程序具有七个基本的编程组件：1）33会员程序有共同的癌症研究兴趣并为学员提供基本心理的教师； 2）一个指定计划教师实验室的两年经验； 3）ITOS计划研究俱乐部提供一个引人入胜的社区论坛，旨在讨论正在进行的工作以及最新发现； 4）共享研究资源研讨会和尖端生物技术方面的量身定制培训； 5）跨学科与受训者在HCC赞助的主题研究务虚会，研讨会，从事的工作进度会议和半小伙子； 6）职业发展研讨会和为受训者提供的课程独立成功； 7）至少有两个专业会议在全国范围内建立网络的机会每年。在第四年，ITOS计划毕业了9名研究员； 1MD，1MD/PHD，7 phds。来自潜水员背景，58％的女性和30.8％的人数不足的种族/族裔少数群体成功过渡到学术界或行业的职位。基于能力，能力，轨迹 MUSC用于癌症有关的培训，以及在其初始资金期间取得的成功成就， ITOS计划每年都要求为七个博士后学员提供支持，这代表增加两个学员职位。总而言之，我们的ITOS计划仅提供独特的经验和机会为选定的ITOS研究员提供的，该计划由一位出色的课程教职员工领导，IS 预计将对新兴的初级调查人员在本地和全国范围内具有极大的吸引力。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Long-term outcomes of pediatric laparoscopic needled-assisted inguinal hernia repair: A 10-year experience.

DOI：
10.1016/j.jpedsurg.2020.09.022
发表时间：
2021-01
期刊：
Journal of pediatric surgery
影响因子：
2.4
作者：
Garcia DI;Baker C;Patel S;Hebra AV;Cina RA;Streck CJ;Lesher AP
通讯作者：
Lesher AP

Interhospital variation of inpatient versus outpatient pediatric burn treatment after emergency department evaluation.

DOI：
10.1016/j.jpedsurg.2020.03.018
发表时间：
2020-10
期刊：
Journal of pediatric surgery
影响因子：
2.4
作者：
Garcia DI;Lesher AP;Corrigan C;Howard HR;Cina RA
通讯作者：
Cina RA

Syrbactin proteasome inhibitor TIR-199 overcomes bortezomib chemoresistance and inhibits multiple myeloma tumor growth in vivo.

DOI：
10.1016/j.leukres.2019.106271
发表时间：
2019-11
期刊：
Leukemia research
影响因子：
2.7
作者：
Marquicia R. Pierce;Reeder M. Robinson;Tannya R. Ibarra-Rivera;M. Pirrung;N. Dolloff;A. Bachmann
通讯作者：
Marquicia R. Pierce;Reeder M. Robinson;Tannya R. Ibarra-Rivera;M. Pirrung;N. Dolloff;A. Bachmann

What is Elective Oncologic Surgery in the Time of COVID-19? A Literature Review of the Impact of Surgical Delays on Outcomes in Patients with Cancer.

DOI：
10.31487/j.cor.2020.06.05
发表时间：
2020-06
期刊：
Clinical oncology and research
影响因子：
0
作者：
Garcia D;Siegel JB;Mahvi DA;Zhang B;Mahvi DM;Camp ER;Graybill W;Savage SJ;Giordano A;Giordano S;Carneiro-Pla D;Javid M;Lesher AP;Abbott A;DeMore NK
通讯作者：
DeMore NK

Structural insights into the mechanism and E2 specificity of the RBR E3 ubiquitin ligase HHARI.

对 RBR E3 泛素连接酶 HHARI 的机制和 E2 特异性的结构见解。