Female Reproductive Tissue Mapping Center Coordination Core

女性生殖组织绘图中心协调核心

• 批准号: 10268240
• 负责人: LOUISE CHANG LAURENT
• 金额: $ 11.53万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-25 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10268240
• 关键词: Agreement; Budgets; Clinical Research; Collaborations; Communication; Communities; Data; Data Analyses; Disclosure; Doctor of Philosophy; Ensure; Female; Funding; Goals; Human BioMolecular Atlas Program; Human Resources; Image; Individual; Institutional Review Boards; Knowledge; Lead; Maintenance; Manuscripts; Metadata; Molecular Profiling; Preparation; Procedures; Progress Reports; Proteomics; Reproducibility; Research Personnel; Resource Sharing; Resources; Sampling; Schedule; Shipping; Site; Structure; Technology; TimeLine; Tissues; Travel; United States National Institutes of Health; Visualization; Work; biobank; collaboratory; data interoperability; data management; data sharing; interoperability; material transfer agreement; meetings; member; operation; programs; reproductive; success; symposium; technology development; tool; transcriptomics; working group

SUMMARY The Coordination Core for the Female Reproductive Tissue Mapping Center (FR TMC) will be responsible for the overall direction of the FR TMC and allocation of effort and other resources, as well as Center management, administration, regulatory compliance, data and resource sharing, and coordination of communication among the component Cores and Projects in the FR TMC. The CC will also facilitate interactions with the other TMCs and the Transformative Technology Development (TTP), Rapid Technology Integration (RTI), HuBMAP Integration, Visualization, and Integration (HIVE) Collaboratory, and Demonstration Project components of HuBMAP. The personnel in the CC will include the FR TMC Steering Committee (comprised of the Center Director, Project Leads, and other Co-Investigators), and the program management staff (Program Manager, Lead Clinical Research Coordinator, and Administrative Assistant). The responsibilities of the CC will be organized in five Aims: 1) Administration (encompassing management of the Center’s budget and organizing travel to annual HuBMAP investigator meetings, scientific conferences, and between FR TMC sites at UC San Diego and Jackson Labs); 2) Program management (including: setting and tracking priorities, goals, and timelines; developing Standard Operating Procedures; tracking samples, metadata, and data; and coordinating preparation of progress reports, abstracts, and manuscripts); 3) Regulatory compliance (including establishment and maintenance of Institutional Review Board approvals, Material Transfer Agreements, Data Use Agreements, and Confidential Disclosure Agreements); 4) Communication management (including: participation in HuBMAP Working Groups and Data Release Teams; and scheduling meetings and conference calls, managing agendas, and keeping minutes); and 5) Data and resource sharing (including working with the DAC to prepare data and metadata for transfer to the HIVE and for public release, and coordinating transfer of materials among FR TMC labs and between the FR TMC and other HuBMAP centers. The structure and smooth operation of the CC will enable us to efficiently collect high- quality biospecimens and generate a broad array of imaging and molecular profiling data using state-of-the art spatial transcriptomic and proteomic technologies. The establishment of detailed Standard Operating Procedures by the CC will ensure the rigor and reproducibility of our results. The CC will also facilitate rapid data and resource sharing with the HIVE, other HuBMAP Centers, and the broader scientific community.

概括 女性生殖组织映射中心（FR TMC）的协调核心将负责 FR TMC的总体方向以及努力和其他资源的分配以及中心 管理，管理，法规合规性，数据和资源共享以及协调 TMC FR中的组件核心和项目之间的通信。 CC也将有助于 与其他TMC和变革性技术开发（TTP）的互动，快速技术 集成（RTI），Hubmap集成，可视化和集成（Hive）协作和演示 Hubmap的项目组成部分。 CC中的人员将包括TMC指导委员会 （由中心主任，项目主管和其他共同投资者组成）以及计划管理 员工（主管，临床研究协调员和行政助理计划经理）。 CC的责任将以五个目的组织：1）行政部门（涵盖管理的管理 中心的预算和组织年度Hubmap调查员会议，科学会议以及 在圣地亚哥分校的TMC站点和杰克逊实验室之间）； 2）计划管理（包括：设置和 跟踪优先级，目标和时间表；制定标准操作程序；跟踪样本， 元数据，并协调进度报告，摘要和手稿的准备）； 3） 监管合规性（包括机构审查委员会批准的建立和维护， 物质转移协议，数据使用协议和机密披露协议）； 4） 沟通管理（包括：参加Hubmap工作组和数据发布团队； 以及安排会议和电话会议，管理议程以及保留会议记录）； 5）数据和 资源共享（包括与DAC一起准备数据和元数据以转移到Hive和 用于公共发布，并协调材料在FR TMC实验室之间以及TMC FR和 其他Hubmap中心。 CC的结构和平滑操作将使我们能够有效地收集高 质量生物测量，并使用最先进的技术产生大量的成像和分子分析数据 空间转录组和蛋白质组学技术。建立详细的标准操作 CC的程序将确保结果的严格性和可重复性。 CC也将有助于快速 与Hive，其他Hubmap中心和更广泛的科学界的数据和资源共享。