Inhibitory synaptic plasticity during learning

学习过程中的抑制性突触可塑性

基本信息

批准号：
10270121
负责人：
ALISON L BARTH
金额：
$ 52.69万
依托单位：
CARNEGIE-MELLON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10270121
关键词：
Acute Address Anatomy Animals Area Association Learning Behavior Behavioral Brain Cells Cerebral cortex Characteristics Chemosensitization Cholinergic Receptors Climacteric Clustered Regularly Interspaced Short Palindromic Repeats Complex Cortical Column Coupled Coupling Data Disinhibition Electrophysiology (science)Esthesia Home environment Image Inhibitory Synapse Interneurons Learning Mediating Memory Methods Modification Mus Neocortex Neuronal Plasticity Neurons Outcome Output Parvalbumins Pathway interactions Psychological reinforcement Publishing Rewards Sensory Signal Transduction Slice Somatosensory Cortex Stimulus Synapses Synaptic plasticity System Tactile Testing Thalamic structure Time Training Transgenic Mice Variant Water base cell type cholinergic classical conditioning experience experimental study in vivo knock-down neocortical neural circuit programs relating to nervous system response sensory cortex sensory input sensory stimulus synaptic inhibition

项目摘要

Abstract What are the neural circuits by which the brain differentiates between incidental and meaningful environmental inputs to enable long-lasting changes in sensation and behavior? Experimental evidence indicates that this distinction may be made at the earliest stages of cortical processing, in primary sensory cortex. Here we will use high-throughput, automated behavioral training in freely-moving mice to determine how the detailed neural circuitry of the cerebral cortex is distinctly changed during acquisition of a tactile reward-based association. Our preliminary data indicate that long-lasting modifications in parvalbumin (PV)-mediated synaptic inhibition is selectively driven by sensory association training but not passive sensory exposure, providing a foothold to investigate the cellular circuitry that distinguishes between different types of experience-dependent plasticity. Using in vivo Ca imaging, targeted electrophysiological recordings and anatomical analyses, we will determine the mechanisms by which specific neural subtypes facilitate learning-related reorganization of the cortical column.

抽象的大脑通过什么神经回路来区分偶然的和有意义的环境输入能够使感觉和行为发生持久的变化？实验性的有证据表明这种区别可能是在皮质处理的最早阶段进行的，在初级感觉皮层。在这里，我们将使用高通量、自动化的行为训练自由移动的小鼠以确定大脑皮层的详细神经回路如何在获得基于触觉奖励的关联过程中发生了明显变化。我们的初步数据表明小白蛋白（PV）介导的突触抑制的持久修饰是由感觉关联训练而不是被动感觉暴露选择性驱动，提供研究区分不同类型的细胞电路的立足点依赖于经验的可塑性。使用体内 Ca 成像，靶向电生理学录音和解剖分析，我们将确定具体的机制神经亚型促进与学习相关的皮质柱重组。