Structural Biology Shared Service

结构生物学共享服务

• 批准号: 10267057
• 负责人: David Joseph Weber
• 金额: --
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267057
• 关键词: Address; Advanced Malignant Neoplasm; American; Area; Baltimore; Biometry; Cancer Biology; Cancer Center; Cells; Chemicals; Collection; Comprehensive Cancer Center; Computer Assisted; Consultations; Cryoelectron Microscopy; Crystallization; Data; Data Analyses; Data Collection; Doctor of Philosophy; Drug Design; Electron Microscopy; Enzymes; Faculty; Flow Cytometry; Funding; Genomics; Grant; Human Resources; Image; Investigational Therapies; Journals; Laboratories; Leadership; Malignant Neoplasms; Maryland; Methodology; Methods; Microscope; Mission; Molecular; Molecular Biology; Molecular Mechanisms of Action; Molecular Probes; Molecular Structure; Nuclear Magnetic Resonance; Nucleic Acids; Outcome; Pathology; Peer Review; Pharmaceutical Chemistry; Population Sciences; Preparation; Principal Investigator; Proteins; Publications; Research; Research Design; Research Personnel; Resolution; Robotics; Roentgen Rays; Sampling; Science; Services; Societies; Source; Strategic Planning; Structural Biologist; Structure; Synchrotrons; Technology; Therapeutic; Training; Universities; X-Ray Crystallography; acronyms; anticancer research; base; bench to bedside; biobank; cancer therapy; collaborative environment; computer center; cryogenics; design; detector; drug candidate; drug discovery; hormone related cancer; innovation; instrument; instrumentation; medical schools; member; neoplasm immunotherapy; particle; programs; research study; screening; structural biology; success; tumor immunology

20.0 Abstract: Structural Biology Shared Service The Structural Biology Shared Service (SBSS) assists investigators in the collection and interpretation of structural biology data derived from three technologies—cryogenic electron microscopy, X-ray crystallography, and nuclear magnetic resonance—as a value-added means to advance cancer biology research. SBSS supports users from all five research programs at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC). The structural biology data from SBSS help investigators derive the molecular mechanisms of action of cancer-related proteins and enzymes and permit the design of molecular agents, including molecular probes as drug candidates for research studies and potential cancer treatments. The three technologies offer complementary approaches to understanding structure and biomolecule mechanisms of action. The expertise of SBSS leadership directs investigators to the appropriate structural biology method(s) that will most efficiently address their scientific questions and then provides strategies for obtaining high-quality analysis. SBSS is heavily used. For example, 18 research groups use two or more structural analysis methods. SBSS facilitates early-stage UMGCCC drug discovery in cooperation with other UMGCCC shared services; the Computer Aided Drug Design Center (CADDC), headed by MacKerell (MSB); and the Center for Biomolecular Therapeutics (CBT), directed by Weber (MSB). The Faculty Oversight Committee, composed of SBSS users and external reviewers, assesses and provides guidance on current services and strategic planning. Overall, SBSS provides UMGCCC investigators with access to state-of-the-art structural biology instrumentation in a collaborative environment that is ideal for basic structure-based drug design research to enable the advancement of high-impact cancer research and bench-to-bedside success. In 2019 SBSS supported studies by 56 investigators, 40 (71.4%) of whom were affiliated with UMGCCC. In 2019 SBSS supported $17.9 million of UMGCCC funding, all of which was peer reviewed. From 2015 to 2019, SBSS supported 164 publications including those in high-impact journals such as Science, Cell, PNAS, Nucleic Acids Research, Journal of the American Chemical Society, and Journal of Molecular Biology.

20.0 摘要：结构生物学共享服务 结构生物学共享服务 (SBSS) 协助研究人员收集和解释 结构生物学数据源自三种技术——低温电子显微镜、X射线晶体学、 和核磁共振——作为推进癌症生物学研究的增值手段。 支持马里兰大学 Marlene 和 Stewart Greenebaum 的所有五个研究项目的用户 综合癌症中心 (UMGCCC) 的结构生物学数据可帮助研究人员得出结论。 癌症相关蛋白质和酶的分子作用机制，并允许设计分子 代理，包括作为研究和潜在癌症治疗候选药物的分子探针。 这三种技术提供了理解结构和生物分子的互补方法 SBSS 领导层的专业知识指导调查人员采取适当的结构。 生物学方法将最有效地解决他们的科学问题，然后提供策略 例如，18 个研究小组使用两个或多个。 SBSS 与其他方法合作促进早期 UMGCCC 药物发现。 UMGCCC 共享服务；由 MacKerell (MSB) 领导的计算机辅助药物设计中心 (CADDC)； 以及由韦伯 (MSB) 领导的生物分子治疗中心 (CBT)。 委员会由 SBSS 用户和外部评审员组成，评估当前的情况并提供指导 总体而言，SBSS 为 UMGCCC 调查人员提供了最先进的服务。 协作环境中的结构生物学仪器非常适合基于基本结构的药物 设计研究，以促进高影响力的癌症研究和实验室到临床的成功。 2019 年 SBSS 支持了 56 名研究人员的研究，其中 40 名（71.4%）2019 年隶属于 UMGCCC。 SBSS 支持了 1790 万美元的 UMGCCC 资金，所有这些资金从 2015 年到 2019 年都经过了同行评审。 支持 164 篇出版物，包括《Science》、《Cell》、《PNAS》、《Nucleic Acids》等高影响力期刊上的出版物 研究、美国化学会杂志和分子生物学杂志。