Structural Biology Shared Service

结构生物学共享服务

• 批准号: 10267057
• 负责人: David Joseph Weber
• 金额: --
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-08 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267057
• 关键词: Address; Advanced Malignant Neoplasm; American; Area; Baltimore; Biometry; Cancer Biology; Cancer Center; Cells; Chemicals; Collection; Comprehensive Cancer Center; Computer Assisted; Consultations; Cryoelectron Microscopy; Crystallization; Data; Data Analyses; Data Collection; Doctor of Philosophy; Drug Design; Electron Microscopy; Enzymes; Faculty; Flow Cytometry; Funding; Genomics; Grant; Human Resources; Image; Investigational Therapies; Journals; Laboratories; Leadership; Malignant Neoplasms; Maryland; Methodology; Methods; Microscope; Mission; Molecular; Molecular Biology; Molecular Mechanisms of Action; Molecular Probes; Molecular Structure; Nuclear Magnetic Resonance; Nucleic Acids; Outcome; Pathology; Peer Review; Pharmaceutical Chemistry; Population Sciences; Preparation; Principal Investigator; Proteins; Publications; Research; Research Design; Research Personnel; Resolution; Robotics; Roentgen Rays; Sampling; Science; Services; Societies; Source; Strategic Planning; Structural Biologist; Structure; Synchrotrons; Technology; Therapeutic; Training; Universities; X-Ray Crystallography; acronyms; anticancer research; base; bench to bedside; biobank; cancer therapy; collaborative environment; computer center; cryogenics; design; detector; drug candidate; drug discovery; hormone related cancer; innovation; instrument; instrumentation; medical schools; member; neoplasm immunotherapy; particle; programs; research study; screening; structural biology; success; tumor immunology

20.0 Abstract: Structural Biology Shared Service The Structural Biology Shared Service (SBSS) assists investigators in the collection and interpretation of structural biology data derived from three technologies—cryogenic electron microscopy, X-ray crystallography, and nuclear magnetic resonance—as a value-added means to advance cancer biology research. SBSS supports users from all five research programs at the University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center (UMGCCC). The structural biology data from SBSS help investigators derive the molecular mechanisms of action of cancer-related proteins and enzymes and permit the design of molecular agents, including molecular probes as drug candidates for research studies and potential cancer treatments. The three technologies offer complementary approaches to understanding structure and biomolecule mechanisms of action. The expertise of SBSS leadership directs investigators to the appropriate structural biology method(s) that will most efficiently address their scientific questions and then provides strategies for obtaining high-quality analysis. SBSS is heavily used. For example, 18 research groups use two or more structural analysis methods. SBSS facilitates early-stage UMGCCC drug discovery in cooperation with other UMGCCC shared services; the Computer Aided Drug Design Center (CADDC), headed by MacKerell (MSB); and the Center for Biomolecular Therapeutics (CBT), directed by Weber (MSB). The Faculty Oversight Committee, composed of SBSS users and external reviewers, assesses and provides guidance on current services and strategic planning. Overall, SBSS provides UMGCCC investigators with access to state-of-the-art structural biology instrumentation in a collaborative environment that is ideal for basic structure-based drug design research to enable the advancement of high-impact cancer research and bench-to-bedside success. In 2019 SBSS supported studies by 56 investigators, 40 (71.4%) of whom were affiliated with UMGCCC. In 2019 SBSS supported $17.9 million of UMGCCC funding, all of which was peer reviewed. From 2015 to 2019, SBSS supported 164 publications including those in high-impact journals such as Science, Cell, PNAS, Nucleic Acids Research, Journal of the American Chemical Society, and Journal of Molecular Biology.

20.0摘要：结构生物学共享服务 结构生物学共享服务（SBSS）协助研究人员收集和解释 源自三种技术的结构生物学数据 - 晶型电子显微镜，X射线晶体学， 和核磁共振 - 作为提高癌症生物学研究的增值手段。 SBSS 为马里兰州大学和斯图尔特·格林鲍姆大学的所有五个研究计划的用户提供支持 综合癌症中心（UMGCCC）。来自SBS的结构生物学数据可帮助研究人员得出 癌症相关蛋白和酶作用的分子机制，并允许设计分子 药物，包括分子问题作为研究研究和潜在癌症治疗的候选药物。 这三种技术提供了理解结构和生物分子的完整方法 作用机理。 SBSS领导力的专业知识指导调查人员进入适当的结构 生物学方法将最有效地解决他们的科学问题，然后提供策略 获得高质量的分析。 SBSS大量使用。例如，18个研究小组使用两个或更多 结构分析方法。 SBSS最爱的早期UMGCCC药物发现与其他 UMGCCC共享服务；由Mackerell（MSB）领导的计算机辅助药物设计中心（CADDC）； 韦伯（MSB）指导的生物分子治疗中心（CBT）。教师的监督 由SBSS用户和外部审核者组成的委员会，评估并提供有关当前的指导 服务和战略计划。总体而言，SBSS为UMGCCC调查人员提供了最先进的访问权限 在协作环境中的结构生物学仪器，非常适合基于结构的药物 设计研究以使高影响力癌症研究和基准对床位的成功发展。在 2019年SBSS支持了56名研究人员的研究，其中40名（71.4％）与UMGCCC相关。 2019年 SBSS支持了1,790万美元的UMGCCC资金，所有这些资金均已同行审查。从2015年到2019年，SBSS 支持164个出版物，包括在科学，细胞，PNA，核酸等高影响期刊中的出版物 研究，美国化学学会杂志和分子生物学杂志。