Differential impacts of co-occurring childhood maltreatment and long-term poly-victimization on chronic physical illnesses via inflammation: Do age at exposure and sexual orientation matter?

同时发生的儿童虐待和长期多重受害对炎症引起的慢性身体疾病的不同影响：暴露年龄和性取向重要吗？

• 批准号: 10266108
• 负责人: Aura Ankita Mishra
• 金额: $ 6.6万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2023-09-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10266108
• 关键词: Acute-Phase Proteins; Address; Adolescence; Adolescent; Adult; Affect; Age; Area; Behavioral; Biological; Biological Markers; Biological Process; Biosocial; C-reactive protein; Caregivers; Child; Child Abuse and Neglect; Childhood; Chronic; Chronic Disease; Chronic stress; Critical Illness; DNA Methylation; DNA analysis; Data; Development; Diabetes Mellitus; Discipline; Evaluation; Exposure to; Funding; Gene Proteins; Goals; Health; Heart; Heterosexuals; Hypertension; Immune; Immunologic Markers; Immunology; Individual; Inflammation; Inflammatory; Influentials; Interleukin-6; Knowledge; Lesbian Gay Bisexual; Life; Life Cycle Stages; Link; Long-Term Effects; Longitudinal Studies; Manuscripts; Mediating; Mediation; Mentors; Methodology; Methods; Modeling; National Longitudinal Survey of Adolescent to Adult Health; Outcome; Pathway interactions; Prevalence; Process; Public Health; Publishing; Reporting; Research; Research Design; Research Ethics; Research Personnel; Research Project Grants; Risk; Role; Sampling; Serum; Serum Markers; Sex Orientation; Sexual Development; Statistical Methods; Stress; Subgroup; TNF gene; Testing; Time; Training; Translational Research; United States; United States National Institutes of Health; Victimization; assault; career; cohort; cost; cytokine; experience; health disparity; health economics; high risk; immune function; improved; inflammatory marker; innovation; intimate partner violence; maltreatment; novel; physical conditioning; polyvictimization; sexual minority; social; social genomics; theories; young adult

Project Summary/Abstract Understanding the differential effects of co-occurring childhood maltreatment prior to age 12 and co-occurring poly-victimization prior to age 18 and until young adulthood on physical chronic illnesses are critical due to their far-reaching public health and economic consequences, particularly for sexual minorities such as lesbian, gay, and bisexual or LGB individuals. Of equal importance is the identification of immune mechanisms that get activated by victimization and meditate the association between each victimization type and chronic physical illnesses, as well as the developmental stage during which exposure to each victimization occurs. Such an evaluation will expand our knowledge of which co-occurring victimization types are most influential for specific chronic biological dysregulation and give us a better understanding of the stability and plasticity of victimization related biological dysregulation. Given that LGB individuals are at a greater risk for each victimization type and at greater risk for health disparities, it is equally likely that compared to heterosexual individuals, LGB individuals will experience greater victimization related biological dysregulation and subsequently higher levels of chronic illnesses. Similarly, victimization exposures in childhood (before age 12) are also generally considered worse for lifelong health outcomes. Therefore, the overarching goal of this project is to address three primary aims: 1) establish the relationship between a) co-occurring childhood maltreatment prior to age 12, b) co-occurring poly-victimization until age 18, and c) co-occurring poly-victimization until young adulthood, and chronic physical illnesses. 2) Examine mediating role of DNA methylation of pro-inflammatory cytokine and CRP genes as well as serum biomarkers of inflammation (e.g. CRP, IL-6, TNF-α) as a mechanism between each victimization type, and chronic physical illnesses. 3) Understand whether and how (stronger vs. weaker associations) the biosocial processes by which co-occurring childhood maltreatment and co-occurring poly- victimization is related to adult health varies by sexual orientation and development stage. This F32 will also allow the Candidate the time and training required to build on her existing expertise required to become an independent and interdisciplinary researcher. Through training with experienced mentors who are leaders in the field, the Candidate will gain 1. expertise in social genomics research and novel statistical methods for analyzing DNA methylation data, 2. knowledge in behavioral immunology and immune mechanisms of physical health, 3. in-depth knowledge of sexual minority health disparities such as LGB individuals, and 4. integration of theory, data and methods across social, biological, and developmental domains and translation of research findings. Training in these areas and in research ethics is integral for completing the research aims, and preparing the Candidate for a career as a NIH-funded researcher investigating victimization related health outcomes among sexual minorities.

项目概要/摘要 了解 12 岁之前同时发生的儿童虐待和同时发生的儿童虐待的不同影响 18 岁之前和成年早期因身体慢性疾病而遭受多重伤害是至关重要的，因为 深远的公共卫生和经济后果，特别是对女同性恋、男同性恋、 同样重要的是识别双性恋或 LGB 个体的免疫机制。 由受害激活并思考每种受害类型与慢性身体疾病之间的联系 疾病，以及发生每次受害的发育阶段。 评估将扩大我们对哪些同时发生的受害类型对特定群体影响最大的认识 慢性生物失调，让我们更好地理解受害的稳定性和可塑性 鉴于 LGB 个体面临的每种受害类型和风险都更大。 与异性恋者相比，LGB 者面临更大的健康差异风险 个人将经历更大的受害相关的生物失调，并随后出现更高的水平 同样，儿童期（12 岁之前）受害暴露也普遍存在。 因此，该项目的总体目标是解决终身健康问题。 三个主要目标： 1) 建立 a) 年龄之前同时发生的儿童虐待之间的关系 12、b) 18 岁之前同时发生多重受害，以及 c) 直到青年时期同时发生多重受害， 2) 检查促炎细胞因子和慢性身体疾病的 DNA 甲基化的介导作用。 CRP 基因以及炎症的血清生物标志物（例如 CRP、IL-6、TNF-α）作为炎症之间的机制 3）了解是否以及如何（更强​​与更弱） 协会）同时发生的儿童虐待和同时发生的多发性虐待的生物社会过程 受害与成人健康有关，因性取向和发育阶段而异。 该 F32 还将为候选人提供所需的时间和培训，以巩固其现有的专业知识 通过与经验丰富的导师的培训成为一名独立的跨学科研究人员。 是该领域的领导者，候选人将获得 1. 社会基因组学研究和新颖统计方面的专业知识 DNA甲基化数据分析方法，2.行为免疫学和免疫学知识 身体健康机制，3.深入了解LGB等性少数健康差异 个人，以及 4. 跨社会、生物和发展的理论、数据和方法的整合 这些领域和研究伦理方面的培训是不可或缺的。 完成研究目标，并为候选人作为 NIH 资助的研究人员的职业生涯做好准备 调查性少数群体中受害相关的健康结果。