Differential impacts of co-occurring childhood maltreatment and long-term poly-victimization on chronic physical illnesses via inflammation: Do age at exposure and sexual orientation matter?

同时发生的儿童虐待和长期多重受害对炎症引起的慢性身体疾病的不同影响：暴露年龄和性取向重要吗？

• 批准号: 10478947
• 负责人: Aura Ankita Mishra
• 金额: $ 6.18万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478947
• 关键词: Acute-Phase Proteins; Address; Adolescence; Adolescent; Adult; Affect; Age; Area; Behavioral; Biological; Biological Markers; Biological Process; Biosocial; C-reactive protein; Caregivers; Child; Child Abuse and Neglect; Childhood; Chronic; Chronic Disease; Chronic stress; Critical Illness; DNA Methylation; DNA analysis; Data; Development; Diabetes Mellitus; Discipline; Evaluation; Exposure to; Funding; Gene Proteins; Goals; Health; Heart; Heterosexuals; Hypertension; Immune; Immunologic Markers; Immunology; Individual; Inflammation; Inflammatory; Influentials; Interleukin-6; Knowledge; Lesbian Gay Bisexual; Life; Life Cycle Stages; Link; Long-Term Effects; Longitudinal Studies; Manuscripts; Mediating; Mediation; Mentors; Methodology; Methods; Modeling; National Longitudinal Survey of Adolescent to Adult Health; Outcome; Pathway interactions; Prevalence; Process; Public Health; Publishing; Reporting; Research; Research Design; Research Ethics; Research Personnel; Research Project Grants; Risk; Role; Sampling; Serum; Serum Markers; Sex Orientation; Sexual Development; Statistical Methods; Stress; Subgroup; TNF gene; Testing; Time; Training; Translational Research; United States; United States National Institutes of Health; Victimization; assault; career; cohort; cost; cytokine; experience; health disparity; health economics; high risk; immune function; improved; inflammatory marker; innovation; intimate partner violence; maltreatment; novel; physical conditioning; polyvictimization; sexual minority; sexual minority health disparity; social; social genomics; theories; young adult; Acute-Phase Proteins; Address; Adolescence; Adolescent; Adult; Affect; Age; Area; Behavioral; Biological; Biological Markers; Biological Process; Biosocial; C-reactive protein; Caregivers; Child; Child Abuse and Neglect; Childhood; Chronic; Chronic Disease; Chronic stress; Critical Illness; DNA Methylation; DNA analysis; Data; Development; Diabetes Mellitus; Discipline; Evaluation; Exposure to; Funding; Gene Proteins; Goals; Health; Heart; Heterosexuals; Hypertension; Immune; Immunologic Markers; Immunology; Individual; Inflammation; Inflammatory; Influentials; Interleukin-6; Knowledge; Lesbian Gay Bisexual; Life; Life Cycle Stages; Link; Long-Term Effects; Longitudinal Studies; Manuscripts; Mediating; Mediation; Mentors; Methodology; Methods; Modeling; National Longitudinal Survey of Adolescent to Adult Health; Outcome; Pathway interactions; Prevalence; Process; Public Health; Publishing; Reporting; Research; Research Design; Research Ethics; Research Personnel; Research Project Grants; Risk; Role; Sampling; Serum; Serum Markers; Sex Orientation; Sexual Development; Statistical Methods; Stress; Subgroup; TNF gene; Testing; Time; Training; Translational Research; United States; United States National Institutes of Health; Victimization; assault; career; cohort; cost; cytokine; experience; health disparity; health economics; high risk; immune function; improved; inflammatory marker; innovation; intimate partner violence; maltreatment; novel; physical conditioning; polyvictimization; sexual minority; sexual minority health disparity; social; social genomics; theories; young adult

Project Summary/Abstract Understanding the differential effects of co-occurring childhood maltreatment prior to age 12 and co-occurring poly-victimization prior to age 18 and until young adulthood on physical chronic illnesses are critical due to their far-reaching public health and economic consequences, particularly for sexual minorities such as lesbian, gay, and bisexual or LGB individuals. Of equal importance is the identification of immune mechanisms that get activated by victimization and meditate the association between each victimization type and chronic physical illnesses, as well as the developmental stage during which exposure to each victimization occurs. Such an evaluation will expand our knowledge of which co-occurring victimization types are most influential for specific chronic biological dysregulation and give us a better understanding of the stability and plasticity of victimization related biological dysregulation. Given that LGB individuals are at a greater risk for each victimization type and at greater risk for health disparities, it is equally likely that compared to heterosexual individuals, LGB individuals will experience greater victimization related biological dysregulation and subsequently higher levels of chronic illnesses. Similarly, victimization exposures in childhood (before age 12) are also generally considered worse for lifelong health outcomes. Therefore, the overarching goal of this project is to address three primary aims: 1) establish the relationship between a) co-occurring childhood maltreatment prior to age 12, b) co-occurring poly-victimization until age 18, and c) co-occurring poly-victimization until young adulthood, and chronic physical illnesses. 2) Examine mediating role of DNA methylation of pro-inflammatory cytokine and CRP genes as well as serum biomarkers of inflammation (e.g. CRP, IL-6, TNF-α) as a mechanism between each victimization type, and chronic physical illnesses. 3) Understand whether and how (stronger vs. weaker associations) the biosocial processes by which co-occurring childhood maltreatment and co-occurring poly- victimization is related to adult health varies by sexual orientation and development stage. This F32 will also allow the Candidate the time and training required to build on her existing expertise required to become an independent and interdisciplinary researcher. Through training with experienced mentors who are leaders in the field, the Candidate will gain 1. expertise in social genomics research and novel statistical methods for analyzing DNA methylation data, 2. knowledge in behavioral immunology and immune mechanisms of physical health, 3. in-depth knowledge of sexual minority health disparities such as LGB individuals, and 4. integration of theory, data and methods across social, biological, and developmental domains and translation of research findings. Training in these areas and in research ethics is integral for completing the research aims, and preparing the Candidate for a career as a NIH-funded researcher investigating victimization related health outcomes among sexual minorities.

项目摘要/摘要 了解12岁之前的儿童虐待同时发生的差异作用，并共同出现 在18岁之前的多维数字化，直到成年为身体慢性疾病至关重要，因此至关重要 深远的公共卫生和经济后果，特别是对于女同性恋，同性恋等性少数群体 和双性恋或LGB个体。同等重要的是识别获得的免疫机制 通过惊喜激活并冥想每种冒险类型与慢性物理的关联 疾病以及每次胜利的发展阶段。 评估将扩大我们对哪种共同出现的胜利类型对特定影响最大的知识 慢性生物学失调，使我们更好地了解胜利的稳定性和可塑性 相关的生物失调。鉴于LGB个人对每种胜利类型的风险更大，并且 健康分布的风险更大，与异性恋者相比，LGB同样有可能 个人将经历更大的胜利与生物失调，随后更高的水平 慢性病。同样，童年时期（12岁之前）的欺诈暴露也一般也是 认为终身健康成果更糟。因此，该项目的总体目标是解决 三个主要目的：1）建立a）年龄段同时发生虐待之间的关系 12，b）直到18岁的共发生的聚-Victimation，c）共同出现的聚维基化直至成年， 和慢性身体疾病。 2）检查促炎细胞因子和 CRP基因以及炎症的血清生物标志物（例如CRP，IL-6，TNF-α）作为一种机制 每种受害类型和慢性身体疾病。 3）了解是否以及如何（强力与弱 协会）生物社会过程，童年时期虐待和同时发生的多个聚会过程 胜利与成人健康有关，因性取向和发展阶段而异。 该F32还将允许候选人根据所需的现有专业知识所需的时间和培训 成为一名独立的跨学科研究人员。通过与经验丰富的导师的培训 是该领域的领导者，候选人将获得1。社会基因组学研究和新统计学方面的专业知识 分析DNA甲基化数据的方法2。行为免疫学和免疫学知识 身体健康机制，3。对性少数群体健康差异（例如LGB）的深入了解 个人和4。社会，生物学和发展的理论，数据和方法的整合 研究结果的领域和翻译。在这些领域和研究伦理中的培训是不可或缺的 完成研究的目的，并为NIH资助的研究人员做好职业的候选人准备 调查性少数群体中与受害的健康结果相关。