Biospecimen Procurement & Utilization Core

生物样本采购

• 批准号: 10265457
• 负责人: Richard Bernard Hayes
• 金额: $ 32.87万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265457
• 关键词: African American; Asians; Biological Specimen database; Blood; Cell Separation; Clinical; Clinical Data; Collaborations; Collection; Communities; Data; Development; Disease; Ensure; Epidemiology; Family; Feces; Food; Fostering; Goals; Hispanics; Human; Human Resources; Immunohistochemistry; Immunophenotyping; Infrastructure; Institution; International; Investigation; Latino; Link; Maintenance; Malignant Neoplasms; Microdissection; Minority Groups; Mission; Nucleic Acids; Nucleic acid sequencing; Oral; Participant; Pathologic; Pathology; Patients; Positioning Attribute; Preparation; Process; Program Research Project Grants; Quality Control; Recording of previous events; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Resources; Sampling; Services; Specimen; Standardization; Structure; T-Lymphocyte; Tissues; Translational Research; Work; biobank; cancer health disparity; cancer site; cohort; design; ethnic minority population; health equity; improved; innovation; melanoma; member; microbiome; microbiota; multi-ethnic; multi-racial; novel; operation; professor; programs; prospective; racial and ethnic; stool sample; translational research program

PROJECT SUMMARY Core B (Biospecimen Procurement & Utilization Core) will serve as the biospecimen and pathology shared resource core for the NYU Cancer Health Disparities (CHD) SPORE. The goal of Core B is to foster translational research on CHD, by providing all NYU CHD SPORE investigators—including research project co-leaders and Developmental Research Program (DRP) awardees—with 1) access to high-quality biospecimens, linked to prospectively collected clinical and pathological data; and 2) innovative services that promote the aims of these projects. To meet the specific needs of the NYU CHD SPORE, Core B places a particular emphasis on collection of biospecimens from racial/ethnic minority populations, including African Americans, Asians, and Hispanics/Latinos. Core B is designed to coordinate the procurement and processing of human biospecimens, including tissue, blood, oral wash samples, and stool, for the NYU CHD SPORE. Core B will improve efficiencies of operations of the NYU CHD SPORE by also serving as the central NYU CHD SPORE Biorepository Database for the development, annotation, and maintenance of this human cancer biospecimen resource, including linkage of specimens with pre-analytical parameters and pathological, clinical, and family history data. Furthermore, in preparation of biospecimens for downstream project-specific analyses, Core B will provide standardized services for the NYU CHD SPORE, including microdissection, immunohistochemistry, extraction of nucleic acids for sequencing, and the disaggregation of tissues into cellular components, for immunophenotyping. Through a governance committee, Core B will also provide oversight of SPORE biospecimen use. Building on the infrastructure of the NYU Food and Microbiome Longitudinal Investigation (FAMiLI) multi-ethnic community cohort and extensive support from NYULH, Core B will provide resources and stimulate collaborations within the NYU CHD SPORE community as well as with outside collaborators, including other currently active SPOREs. Given the considerable translational research infrastructure and resources at NYU, Core B personnel will also work closely with the Administrative Core to ensure the most efficient use of institutional resources without duplicating efforts. Overall, Core B will provide high quality, annotated biospecimens to all SPORE studies to support the NYU CHD SPORE’s mission to increase orodigestive tract cancer health equity by identifying, understanding, and controlling the microbiota related to these diseases.

项目摘要 核心B（双训练采购和利用率核心）将作为共享的生物环境和病理 NYU癌症健康差异（CHD）孢子的资源核心。核心B的目标是促进翻译 冠心病研究，通过为所有纽约联邦冠心病孢子调查员提供 - 包括研究项目共同领导者和 发展研究计划（DRP）获奖者 - 1）获得高质量的生物测量，与 前瞻性收集的临床和病理数据； 2）促进这些目标的创新服务 项目。为了满足NYU CHD孢子的特定需求，核心B特别强调收集 来自种族/族裔少数族裔的生物种群，包括非裔美国人，亚洲人和 西班牙裔/拉丁裔。 Core B旨在协调人类生物测量的采购和处理，包括组织， 血液，口腔清洗样品和凳子，用于纽约冠状动脉孢子。核心B将提高运营效率 NYU CHD孢子也是NYU中央冠心病孢子生物座数据库 这种人类癌症生物环境资源的开发，注释和维护，包括 具有分析前参数以及病理，临床和家族史数据的标本。此外，在 为下游项目特定分析的生物测量准备，核心B将提供标准化服务 对于NYU CHD孢子，包括微分解，免疫组织化学，提取核酸的核酸 测序，将组织分解为细胞成分，以进行免疫表型。通过一个 核心B治理委员会还将监督孢子生物仿生的使用。建立在 NYU食品和微生物纵向研究（Famili）多种族社区的基础设施 NYULH的队列和广泛的支持，Core B将提供资源并刺激合作 NYU CHD Spore社区以及外部合作者，包括其他目前活跃的孢子。 鉴于纽约大学的大量翻译研究基础架构和资源，核心B人员也将 与行政核心紧密合作，以确保最有效地利用机构资源 复制工作。总体而言，核心B将为所有孢子研究提供高质量的带注释的生物测量 支持NYU CHD Spore的使命，以通过识别， 理解并控制与这些疾病有关的微生物群。