Studies of other risk factors for radiosensitive tumors

放射敏感性肿瘤其他危险因素的研究

• 批准号: 10263783
• 负责人: Cari Kitahara
• 金额: $ 28.76万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263783
• 关键词: Back; Cancer Patient; Child; Chinese People; County; Data; Data Set; Disease; Environmental Exposure; Etiology; European; Evaluation; Family; Gallbladder; Genetic; Hospitals; Incidence; Individual; Interview; Life Style; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Malignant neoplasm of brain; Malignant neoplasm of thyroid; Mission; Obesity; Pilot Projects; Play; Population Programs; Prospective Studies; Publishing; Radiation Tolerance; Research; Risk; Risk Factors; Role; Sampling; Site; Testing; Thyroid Gland; Work; cancer subtypes; cohort; community intervention; intervention program; mortality; rare cancer; tumor; waist circumference

Thyroid cancer incidence rates have been increasing for the last 3 decades in the US and the reasons for this are largely unknown. We have been studying potential risk factors for the disease in a pooled analysis of 5 NCI prospective studies. This pooling project provided some of the strongest evidence to date that obesity may be a risk factor for thyroid cancer and the rising obesity rates could therefore be part of the explanation for the rise in thyroid cancer incidence rates. We are now expanding this pooling project to include data from 15 European and US cohorts to examine the relationship in more detail including the risk associated with central adiposity and the relationship between obesity and rarer thyroid cancer subtypes.NCI Cohort Consortium BMI Pooling Project - We built a rich dataset of lifestyle risk factor and mortality data from 20 prospective studies and over 1.5 million people to study the relationship between BMI and all cause mortality. The results from this detailed analysis published in 2010 suggested that optimal BMI was in the range 20-25. We are currently exploring the association between waist circumference and all cause mortality, and expanding the pooling project to look at cancer incidence for rare cancers including thyroid and gallbladder. These cancers are typically difficult to study in individual cohorts because the numbers of cases is limited.Childhood Cancer In Chinese Children and Family Cohorts -We are conducting two pilot studies to test the feasibility of (1) follow and participation in interviews of a sample of 500 families from two county sites where the Community Intervention Program (CIP) was carried out in the mid-1990s and (2) identification of incident pediatric cancers arising among thoseborn during 1994-96 in hospitals serving the CIP population and ability to link these pediatric cancer patients back to the CIP population. The CIP community intervention program trial, which was carried out during 1994-96 i

在美国，甲状腺癌的发病率在过去的30年中一直在提高，原因在很大程度上是未知的。 在对5个NCI前瞻性研究的合并分析中，我们一直在研究该疾病的潜在危险因素。 该合并项目迄今为止提供了一些最有力的证据，表明肥胖症可能是甲状腺癌的危险因素，因此，肥胖率上升可能是甲状腺癌发病率上升的解释的一部分。 现在，我们正在扩大该集合项目，以包括15个欧洲和美国同伙的数据，以更详细地检查这种关系，包括与中心肥胖相关的风险以及肥胖与稀有甲状腺癌的子类型之间的关系。NCICOHORT COLHORT BMI BMI POMING POMING项目 - 我们建立了来自20千万人的生活方式风险和死亡率数据的富裕数据集，并构建了100万人的关系。 2010年发表的详细分析的结果表明，最佳BMI在20-25范围内。 我们目前正在探索腰围与所有引起死亡率之间的关联，并扩大集合项目，以查看包括甲状腺和胆囊在内的罕见癌症的癌症发病率。 这些癌症通常很难在各个同类群中研究，因为病例的数量受到限制。中国儿童和家庭同伙的癌症 - 我们正在进行两项试点研究，以测试（1）跟随（1）跟随并参与来自两个县现场的500个家庭的访谈，这些县级社区干预计划（CIP）在中期和（CIP）中均在1990年代的pedice（2）中携带了（2），并在（2）中遇到了（2），并在（2）中识别了（2），并参与了（2）的（2）。 1994 - 96年的医院，为CIP人群提供服务，并能够将这些小儿癌患者与CIP人群联系起来。 CIP社区干预计划试验是在1994 - 96年期间进行的