Clinical Laboratory Core

临床实验室核心

• 批准号: 10259691
• 负责人: JENNIFER W. TIDEY
• 金额: $ 65.72万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10259691
• 关键词: Achievement; Adverse event; Alcohols; Aliquot; Behavioral; Biological; Biological Assay; Biological Markers; Biological databases; Blood; Cannabis; Carcinogen exposure; Centers of Research Excellence; Chronic; Chronic Disease; Clinical; Complement; Consult; Data; Data Analyses; Data Collection; Databases; Development; Disease; Eligibility Determination; Ensure; Environmental Risk Factor; Enzymes; Equipment; Faculty; Funding; Future; Goals; HIV; Hormones; Hospitals; Human; Human Resources; Hypertension; Immune system; Inflammatory; Intervention; Laboratories; Link; Liver; Lung; Measures; Medical; Medical History; Methodology; NCI Center for Cancer Research; Opioid; Outcome; Patients; Physical Examination; Physiological; Pilot Projects; Placebos; Procedures; Process; Questionnaires; Randomized; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Rheumatoid Arthritis; Rhode Island; Risk; Risk Factors; Saliva; Sampling; Scientist; Services; Stress; Substance Use Disorder; Techniques; Testing; Tobacco; Training; Universities; Urine; addiction; behavioral pharmacology; biobank; biobehavior; causal model; chronic pain; cost; data management; design; disorder risk; experience; experimental study; follow-up; improved; innovation; insight; multidisciplinary; opioid use disorder; participant safety; patient population; pulmonary function; research and development; response; secondary analysis; substance use; systemic inflammatory response; web portal

Abstract Substance use is associated with increased risk of, progression to, and negative outcomes from chronic disease. Although associations between substance use disorders (SUDs) and chronic disease are well documented, specific mechanisms underlying these associations are poorly understood and underappreciated. Experimental studies that use placebo-controlled, randomized designs are essential for understanding physiological mechanisms that link SUDs and chronic disease. The research and pilot projects in the Center for Addiction and Disease Risk Exacerbation (CADRE) COBRE at Brown University will investigate physiological mechanisms underlying the effects of opioids, cannabis, tobacco, and alcohol on risks for and progression of SUD-related disease. Mechanisms to be studied in the initial four CADRE research projects include systemic inflammation, immune system dysregulation, high blood pressure, pulmonary effects and carcinogen exposure. The CADRE's Clinical Laboratory Core (CLC) will provide the current and future CADRE research and pilot project investigators with the space, supplies, equipment, technical capability, scientific expertise and data management/analysis expertise necessary to meet the needs of their projects. These resources are not otherwise available at Brown, and are essential for achieving the Specific Aims of the CADRE projects. Provision of these resources via the CLC will improve efficiency, consistency and economy of scale across projects. Specific Aim 1 of the CLC Core is to provide resources necessary for developing and sustaining a multi-disciplinary center focused on SUDs and chronic disease. Specific Aim 2 is to facilitate and coordinate assay and other services provided to the CADRE investigators through neighboring COBREs. Specific Aim 3, an exploratory aim, is to build a center-wide biobank and database of biological, behavioral and environmental risk factors associated with the development and progression of SUDs and chronic disease. Resources provided by the CLC will build on and complement, but not overlap, resources currently available at Brown. The successful achievement of these aims will be a thematically- and technically-linked center that supports the initial and future projects, enhances the competitiveness of the project leaders for independent external funding, becomes a national leader in understanding biobehavioral mechanisms linking SUDs and chronic disease, and serves as a resource for training and research within Brown, regionally, and nationally.

抽象的 使用物质的风险增加，慢性进展的风险和负面结果 疾病。尽管药物使用障碍（SUD）和慢性疾病之间的关联很好 这些关联所基于的有记录的特定机制对这些关联的理解不足和低估。 使用安慰剂对照，随机设计的实验研究对于理解至关重要 将泡沫和慢性疾病联系起来的生理机制。中心的研究和试点项目 布朗大学的成瘾和疾病风险加剧（干部）的毛茸茸将调查 阿片类药物，大麻，烟草和酒精对风险和酒精的影响的生理机制 与SUD相关疾病的进展。在最初的四个干部研究项目中需要研究的机制 包括全身性炎症，免疫系统失调，高血压，肺部作用和 致癌物暴露。干部的临床实验室核心（CLC）将提供当前和未来的干部 研究和试点项目调查人员具有空间，供应，设备，技术能力，科学的研究者 满足其项目需求所需的专业知识和数据管理/分析专业知识。这些 Brown否则无法提供资源，对于实现特定目标至关重要 干部项目。通过CLC提供这些资源将提高效率，一致性和经济 跨项目扩展。 CLC核心的特定目的1是为开发和 维持一个集中于SUD和慢性疾病的多学科中心。具体目标2是促进和 协调通过邻近的Cobres向干部调查人员提供的协调测定和其他服务。 特定目标3是一个探索性目的，是建立一个中央范围的生物库和生物学，行为和行为和数据库 与SUD和慢性疾病的发展和进展相关的环境风险因素。 CLC提供的资源将建立和补充，但不重叠，目前可用的资源 棕色的。这些目标的成功成就将是一个主题和技术链接的中心 支持初始和未来的项目，增强项目负责人的竞争力 外部资金，成为了解与泡沫和联系的生物行为机制的国家领导者 慢性疾病，是布朗，区域和全国内培训和研究的资源。