Alcohol Use in College Students:Cognition and fMRI

大学生饮酒情况：认知与功能磁共振成像

• 批准号: 8127658
• 负责人: GODFREY D PEARLSON
• 金额: $ 55.25万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8127658
• 关键词: 21 year old; Achievement; Acute; Adolescence; Adolescent; Adult; Affect; Alcohol abuse; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alcohols; Amygdaloid structure; Back; Brain; Characteristics; Cognition; Cognitive; Connecticut; Consumption; Data; Data Set; Development; Diagnostic and Statistical Manual; Dose; Dropout; Drug abuse; Drug usage; Event; Family history of; Functional Magnetic Resonance Imaging; Gambling; Goals; Health; Heavy Drinking; Hippocampus (Brain); Image; Impaired cognition; Impairment; Impulsivity; Incentives; Iowa; Life; Link; Literature; MRI Scans; Magnetic Resonance Imaging; Marijuana; Measures; Memory; Modeling; Moods; Neurocognitive; Nucleus Accumbens; Online Systems; Outcome; Participant; Pattern; Pharmaceutical Preparations; Procedures; Psychiatric Diagnosis; Recruitment Activity; Relative (related person); Reporting; Reproducibility; Research; Research Personnel; Rewards; Risk; Risk Factors; Sampling; Short-Term Memory; Statistical Methods; Stimulus; Stress; Structure; Students; Substance abuse problem; System; Testing; Theoretical model; Time; Toxicology; Universities; Urine; Withdrawal; adverse outcome; alcohol effect; alcohol risk; binge drinking; cognitive function; college; college drinking; discounting; disturbance in affect; drinking; executive function; experience; follow-up; high risk; insight; instrument; male; member; multitask; neuropsychiatry; novel; response; university student; virtual; young adult

DESCRIPTION (provided by applicant): Adolescents, especially college students, are at high risk for problem drinking, but the resulting long term consequences on brain development and function are not well studied. In this 5-year proposal, the investigators will recruit a total of 2000 18-21 year old first-year students (50% male) from 2 demographically distinct local colleges in CT; Central Connecticut State University and Trinity College. All students will be characterized at baseline at their respective campuses on a comprehensive battery of cognitive tasks, some assessing risk for problem drinking in the context of an integrative risk model and others previously identified as being sensitive to effects of alcohol abuse in adolescents. All participants will also be assessed on instruments measuring amount and patterns of current and past alcohol and drug use, consequences of use (eg mood alteration, DWI), and family history of substance use. Academic grades and SAT/ACT scores will be recorded. The sample will be stratified by alcohol use patterns and a total of 300 representative members derived from use quartiles (over-represented from the heaviest quartile, especially binge-pattern users) will undergo additional detailed assessment at the Olin Neuropsychiatry Research Center on 4 functional MRI (fMRI) paradigms assessing a. hippocampal integrity (a virtual maze spatial memory task), b. working memory circuitry (a modified Sternberg paradigm), c. reward anticipation (a monetary incentive delay task) and d. ability to inhibit a pre-potent stimulus (a Go/No-Go task), plus structural MRI and urine toxicology testing. Monthly, all participants will complete web-based ratings of alcohol and drug use amounts and patterns, mood, life events, stress and adverse consequences of use. Two years post initial testing, all available participants (~90%) will repeat the initial cognitive test battery (using alternate test forms) and detailed substance use measures. Of the 300 initial fMRI participants, the ~85% available and willing will repeat the imaging paradigms. The 3 overarching aims are to identify initial predictors of persisting alcohol and drug abuse, to detect early evidence of alcohol and drug-related impairment of brain function & cognitive problems and to determine whether particular patterns of drinking, especially binging, are most associated with cognitive decline over the 2 yrs of assessment. As part of the project we will test a theoretical model of how brain structure and function explain key relationships between risk and alcohol/substance use outcome, incorporating highly novel measures using data fusion, in order to better accomplish the overall goals. The PI and his collaborators have extensive experience with the tasks and procedures used in this Project, including web-based tracking of alcohol use. PUBLIC HEALTH RELEVANCE: US college students are at high risk for problem drinking. This project will recruit and test cognitively 2000 first-year students from local colleges in Connecticut, fMRI scan a representative sub-sample and assess alcohol and drug use by web-based reporting over 2 years, when all students will be retested/rescanned. Findings from this study will provide important insights on risk factors for problem drinking and how alcohol use impacts the developing adolescent brain.

描述（由申请人提供）：青少年，尤其是大学生，饮酒问题的风险很高，但是对大脑发育和功能的长期后果并没有得到很好的研究。在这项为期5年的提案中，调查人员将招募来自CT的2个人口统计学上不同的本地学院的2000年18-21岁的一年级学生（50％男性）；中央康涅狄格州立大学和三一学院。所有学生都将在各自校园的基线中进行全面的认知任务，其中一些学生在综合风险模型的背景下评估了饮酒的风险，而其他人则以前被确定为对青少年酒精滥用的影响敏感。还将对所有参与者进行评估，以测量当前和过去酒精和吸毒的数量和模式，使用的后果（例如情绪改变，DWI）以及药物使用的家族史。将记录学术成绩和SAT/ACT分数。该样本将按照饮酒方式进行分层，总共有300个由使用四分位数得出的代表性成员（与最重的四分位数，尤其是Binge-Pattern用户相关的代表性成员）将在4个功能性MRI（FMRI）评估A的Olin Neuropsychiation Research Center进行其他详细评估。海马完整性（虚拟迷宫空间内存任务），b。工作记忆电路（修改后的Sternberg范式），c。奖励预期（货币激励延迟任务）和d。能够抑制预直动刺激（GO/NO-GO任务），以及结构性MRI和尿液毒理学测试的能力。每月，所有参与者将完成基于网络的酒精和药物使用量和模式，情绪，生活事件，压力和使用的不利后果的评级。初始测试两年后，所有可用的参与者（〜90％）将重复初始认知测试电池（使用替代测试表）和详细的药物使用方法。在300名初始fMRI参与者中，约有85％的可用和愿意重复成像范例。这三个总体目的是确定持续酒精和药物滥用的初始预测指标，以检测早期的脑功能和认知问题损害的证据，并确定在2年评估中，特定的饮酒模式，尤其是饮酒模式是否与认知能力下降相关。作为项目的一部分，我们将测试一个理论模型，即大脑结构和功能如何解释风险与酒精/物质使用结果之间的关键关系，并使用数据融合进行了高度新颖的措施，以便更好地实现总体目标。 PI和他的合作者在该项目中使用的任务和程序有丰富的经验，包括基于Web的酒精使用跟踪。公共卫生相关性：美国大学生饮酒问题的风险很高。该项目将招募和测试来自康涅狄格州本地学院的2000年一年级学生，fMRI扫描了代表性子样本，并评估了2年以上的基于Web的报告，并评估所有学生的饮酒和吸毒。这项研究的结果将为饮酒的风险因素以及酒精使用如何影响发展中的大脑提供重要的见解。