Acute Effects of Exercise in Smokers with Schizophrenia

运动对患有精神分裂症的吸烟者的急性影响

• 批准号: 8424266
• 负责人: JENNIFER W. TIDEY
• 金额: $ 23.37万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8424266
• 关键词: Acute; Affect; Antipsychotic Agents; Behavioral; Blood; Cholesterol; Cigarette; Cigarette Smoker; Clinical; Coronary heart disease; Cues; Development; Diabetes Mellitus; Effectiveness; Environment; Exercise; Exposure to; Gender; General Population; Goals; Habits; Hypertension; Intention; Laboratories; Life Style; Measures; Methods; Moods; Morbidity - disease rate; Neurobiology; Nicotine Withdrawal; Obesity; Outcome Measure; Participant; Patients; Pharmaceutical Preparations; Physical activity; Population; Relapse; Research; Research Project Grants; Risk; Risk Factors; Schizophrenia; Smoker; Smoking; Smoking Behavior; Smoking Cessation Intervention; Staging; Testing; Time; United States National Institutes of Health; Walking; Withdrawal Symptom; atypical antipsychotic; behavior measurement; cardiovascular risk factor; cigarette smoking; craving; design; experience; heart disease risk; improved; in vivo; modifiable risk; mortality; prevent; programs; research study; response; severe mental illness; smoking cessation

DESCRIPTION (provided by applicant): People with schizophrenia have two- to three-times the mortality risk of the general population. This is primarily due to their unusually high rates o cigarette smoking, as well as other cardiovascular risk factors such as physical inactivity, obesity, high blood cholesterol and diabetes. Effective smoking treatments are needed to reduce morbidity and mortality in this population. Over a dozen experimental studies indicate that walking and other forms of exercise acutely reduce cigarette craving, nicotine withdrawal symptoms and smoking behavior in non-psychiatric smokers. However, the effects of acute exercise on smoking measures have not been studied in smokers with schizophrenia. The primary aim of this NIH Exploratory/Developmental (R21) Research Grant application is to investigate the acute effects of exercise, compared to a passive control condition, on subjective and behavioral smoking measures in smokers with schizophrenia. As episodic craving following exposure to smoking cues is associated with relapse during quit attempts, the secondary aim is to investigate whether exposure to smoking cues alters the ability of exercise to reduce cigarette craving and other smoking measures. The tertiary aim is to investigate whether factors known to moderate responses to smoking cessation medications (gender, antipsychotic medication type, intention to quit smoking) moderate the effects of exercise on smoking measures. This study will use a within-subjects, repeated-measures design, in which participants will undergo 1 practice session followed by 4 experimental sessions: (1) smoking cues followed by exercise, (2) smoking cues followed by passive activity, (3) neutral cues followed by exercise, (4) neutral cues followed by passive activity. Outcome measures include cigarette craving, nicotine withdrawal symptoms, mood and smoking behavior. If the results of this study indicate that walking acutely reduces craving and smoking in smokers with schizophrenia, the next step in this research would be to test the effectiveness of a smoking cessation intervention that incorporates exercise bouts as a behavioral strategy for improving smoking cessation rates in this population.

描述（由申请人提供）：精神分裂症患者的死亡人数死亡风险二十倍。这主要是由于它们的吸烟率异常高，以及其他心血管危险因素，例如身体不活跃，肥胖，高血液胆固醇和糖尿病。需要有效的吸烟治疗来降低该人群的发病率和死亡率。超过十几个实验研究表明，步行和其他形式的运动急性减少了渴望香烟的渴望，尼古丁戒断症状和非精神病吸烟者的吸烟行为。但是，在精神分裂症的吸烟者中尚未研究急性运动对吸烟措施的影响。这项NIH探索/发育（R21）研究赠款的主要目的是调查与被动控制条件相比，对精神分裂症吸烟者的主观和行为吸烟措施的急性影响。由于暴露于吸烟提示后的情节渴望与戒烟期间的复发有关，因此次要的目的是调查暴露于吸烟提示是否会改变锻炼能力减少香烟渴望和其他吸烟措施的能力。第三级目的是调查已知对戒烟药物反应中等反应的因素（性别，抗精神病药类型，戒烟意图）是否会减轻运动对吸烟措施的影响。这项研究将使用受试者内，重复测量设计，其中参与者将接受1个练习会议，然后进行4个实验会议：（1）吸烟提示随后进行运动，（2）吸烟提示，然后进行被动性活动，（3）中性提示，然后进行运动，（4）中性线索，次级中性线索，然后进行被动活动。结果措施包括渴望香烟，尼古丁戒断症状，​​情绪和吸烟行为。如果这项研究的结果表明，在精神分裂症的吸烟者中，急性步行会减少渴望和吸烟，那么这项研究的下一步是测试戒烟干预措施的有效性，将运动抗体作为改善该人群吸烟率的行为策略的有效性。