Admin Core

管理核心

• 批准号: 10256769
• 负责人: Lindsay A. Farrer
• 金额: $ 57.42万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10256769
• 关键词: Accounting; Address; Administrative Personnel; Advisory Committees; Alzheimer disease prevention; Alzheimer' s Disease; Ancillary Study; Applications Grants; Archives; Behavioral; Boston; Brain imaging; Budgets; Clinic; Clinical; Cognitive; Collaborations; Communities; Contracts; Data; Dementia; Diagnosis; Disease; Ensure; Etiology; Faculty; Feedback; Formulation; Fostering; Framingham Heart Study; Funding; Genetic Markers; Goals; Grant; Health; Infrastructure; Institution; Interactive Communication; International; Leadership; Logistics; Magnetic Resonance Imaging; Mission; Monitor; National Heart, Lung, and Blood Institute; National Institute on Aging; Neurologic; Neuropsychological Tests; Neuropsychology; Outcome; Participant; Pathogenesis; Performance; Persons; Pilot Projects; Policies; Postdoctoral Fellow; Process; Productivity; Progress Reports; Public Health; Publications; Reporting; Research; Research Activity; Research Personnel; Research Priority; Research Support; Resources; Schedule; Science; Source; Thinking; Time; Travel; United States National Institutes of Health; Universities; Wages; adjudicate; aging brain; base; cohort; data access; data resource; effectiveness evaluation; human subject; improved; innovation; medical schools; meetings; operation; payment; programs; success; symposium; synergism

The mission of the Framingham Heart Study–Brain Aging Program (FHS-BAP) is to conduct, facilitate and promote high impact research on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer disease (AD) and related disorders. The Administrative Core serves as a focal organizational point to organize and harmonize research activities of the Clinical, Neuropsychology, and Data Cores and Projects 1-3 to maximize synergy, efficiency and productivity. In the proposed funding period, the Administrative Core will guide the extension and expansion of the rich FHS data resource and establish a management infrastructure that will greatly increase the sharing and utilization of this resource by other researchers worldwide. To accomplish these central goals, the Administrative Core will serve as the interface between internal FHS-BAP activities and external entities, and ensure that FHS-BAP activities meet all Core and project milestones and are consistent with the National Institute of Aging (NIA) AD research mission and in full compliance with all human subjects, and scientific integrity policy requirements of the NIH. We will form an External Advisory Committee (EAC) to advise on the formulation and execution of FHS-BAP priorities and proactively identify opportunities that will keep us on the forefront of forward-thinking science. Key to executing the Administrative Core's mission is to provide appropriate financial oversight of the entire FHS-BAP, track the disposition of materials provided and the outcomes of FHS-BAP supported research (publications and funded activities) and present progress in meeting the stated aims to the EAC feedback will be critical in assessing effectiveness of operational activities in meeting research priorities and their oversight and continuous input for improvements help ensure we achieve our stated goals. Additionally, consideration and coordination of FHS-BAP day-to-day operations with other FHS research programs (e.g., NHLBI funded FHS contract to support core health exams of FHS cohorts) and other ancillary studies that are collecting data from FHS participants at the FHS clinic based in Framingham, MA will be done in collaboration with an Internal Advisory Board (IAB), consisting of locally based BU faculty to better address time-sensitive logistical issues. The Administrative Core will also promote new innovative AD research using data generated by the FHS-BAP through a pilot project program that will encourage grant applications from junior faculty and postdoctoral fellows, as well as from established faculty who are new to the AD field, throughout BU and possibly other institutions. Additional efforts to foster innovative AD research will be facilitating cross-core/project interactions by promotion of collaborations between FHS-BAP investigators with local, national, and international research programs, by representing the FHS-BAP at scientific meetings and publicizing FHS-BAP data access and use through the Data Core and coordinating with the BU Alzheimer Disease Center to host seminars and symposia focused on AD research.

弗雷明汉心脏研究 - 大脑老化计划 (FHS-BAP) 的使命是开展、促进和 促进阿尔茨海默病的病因、发病机制、诊断、治疗和预防方面的高影响力研究 疾病（AD）和相关疾病的行政核心作为组织的焦点组织点。 协调临床、神经心理学和数据核心和项目 1-3 的研究活动，以 在拟议的资助期内，行政核心将指导最大限度地发挥协同作用、效率和生产力。 丰富的FHS数据资源的延伸和扩展，并建立管理基础设施， 大大增加全世界其他研究人员对该资源的共享和利用，以实现这些目标。 中心目标，管理核心将充当内部 FHS-BAP 活动和 外部实体，并确保 FHS-BAP 活动满足所有核心和项目里程碑并且保持一致 与国家老龄化研究所 (NIA) AD 研究任务并完全符合所有人类受试者的要求， 以及 NIH 的科学诚信政策要求 我们将成立一个外部咨询委员会 (EAC) 就 FHS-BAP 优先事项的制定和执行提供建议，并主动识别机会 让我们处于前瞻性科学的最前沿 执行行政核心使命的关键是： 对整个 FHS-BAP 提供适当的财务监督，跟踪所提供材料的处置情况，以及 FHS-BAP 支持的研究成果（出版物和资助活动）以及目前的进展 达到 EAC 反馈的既定目标对于评估业务活动的有效性至关重要 在满足研究优先事项及其监督和持续改进投入方面有助于确保我们实现 此外，考虑并协调 FHS-BAP 与其他 FHS 的日常运营。 研究计划（例如，NHLBI 资助的 FHS 合同，以支持 FHS 队列的核心健康检查）和其他 正在马萨诸塞州弗雷明汉 FHS 诊所收集 FHS 参与者数据的辅助研究将 与内部顾问委员会 (IAB) 合作完成，该委员会由当地 BU 教师组成，以更好地 解决时间敏感的后勤问题。行政核心还将促进新的创新性AD研究。 使用 FHS-BAP 通过试点项目计划生成的数据，该计划将鼓励赠款申请 来自初级教师和博士后研究员，以及新进入 AD 领域的老教师， 整个波士顿大学和其他机构将做出更多努力来促进创新性 AD 研究。 通过促进 FHS-BAP 调查人员与 地方、国家和国际研究计划，通过代表 FHS-BAP 参加科学会议和 通过数据核心公开 FHS-BAP 数据访问和使用，并与阿尔茨海默病学部协调 疾病中心举办专注于AD研究的研讨会和专题讨论会。