Administrative Core

行政核心

• 批准号: 10410644
• 负责人: Mina Kay Chung
• 金额: $ 16.1万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10410644
• 关键词: Accounting; Address; Animal Experimentation; Animals; Atrial Fibrillation; Awareness; Back; Basic Science; Biological; Cell model; Cells; Clinic; Clinical; Collaborations; Communication; Data; Documentation; Drug Interactions; Electrophysiology (science); Ensure; Environment; Experimental Designs; Funding; Generations; Genes; Genetic; Genomics; Goals; Grant; Heart Atrium; Human; Human Subject Research; Information Dissemination; Leadership; Link; Maintenance; Manuscripts; Mentors; Metabolism; Monitor; Mus; National Heart, Lung, and Blood Institute; Office of Administrative Management; Oral; Participant; Performance; Phenotype; Preparation; Preventive; Progress Reports; Reporting; Reproducibility; Research; Research Personnel; Resources; Schedule; Science; Scientist; Services; Systems Biology; Therapeutic; Time; Translating; Visit; Work; cardiac tissue engineering; design; experimental study; gene interaction; genome wide association study; human subject; meetings; mouse model; operation; professional atmosphere; professor; programs; responsible research conduct; sex; synergism

ADMINISTRATIVE CORE (AC) PROJECT/SUMMARY ABSTRACT The overall goals of the Administrative Core (AC) are to provide organizational, administrative, fiscal, communication, and reporting support to each Project and Core within the Program Project (P01), entitled "Atrial Fibrillation Post-GWAS: Mechanisms to Treatment." Our overall theme is to translate AF genomic discoveries back to the bedside, focusing on genes to mechanisms, genes to drugs, and interactions of genes with metabolism and environment. In conjunction with the Executive Committee (EC), consisting of the Program Director, Project Leads and Core Directors, the AC will promote collaboration and synergy for all P01 components; centrally monitor and evaluate their performance; and facilitate interactions with the Internal Advisory Board (IAB) and External Advisory Board (EAB). The AC will promote integration, efficiency of resource use, and organizational and administrative support. The AC will be essential in coordinating all communications and reviewing all activities among all Projects and all Cores. Importantly, the AC will work closely with the EC and Cores to coordinate generation, maintenance, and experimental use of human cell and mouse models that will optimize experimental design, use of these resources, and integration of all Projects and Cores to efficiently accelerate the Program towards completion of its goals. The aims of the Core are to: 1) Promote collaboration and integration of the Program by providing organizational and administrative support; 2) Facilitate scientific exchange, dissemination of results, and communications; 3) Evaluate and promote research progress; 4) Provide managerial and fiscal grant management; and 5) Ensure and monitor best practices, resource utilization and coordination. The Core will promote best practices for rigor and responsibility, animal and human subjects research, responsible conduct of research, and mentoring and coaching of early stage investigators. The AC will monitor Projects and Scientific Cores and assure that sex as a biological variable has been addressed. In summary, the Administrative Core will function to unify and coordinate activities amongst the Program Project participants. It will facilitate organizational and administrative management of the Program, provide centralized access and coordination for cell and mouse experiment planning, and enhance significance, scope and scale of the projects. The services of this core do not replicate efforts of established cores at Cleveland Clinic, making this core uniquely designed to support P01 investigators.

行政核心（AC） 项目/摘要摘要 行政核心（AC）的总体目标是提供组织，行政，财政， 对计划项目（P01）中每个项目和核心的沟通和报告支持 “ GWAS后房颤：治疗机制。”我们的总体主题是翻译AF基因组 发现回到床边，专注于机制，药物基因以及相互作用的基因 具有新陈代谢和环境的基因。与执行委员会（EC）一起 计划主管，项目负责人和核心主管，AC将促进合作和协同作用 所有P01组件；中央监视和评估其性能；并促进与 内部顾问委员会（IAB）和外部顾问委员会（EAB）。 AC将促进整合， 资源使用效率以及组织和行政支持。 AC将是必不可少的 协调所有沟通并审查所有项目和所有核心之间的所有活动。重要的是， AC将与EC和核心紧密合作，以协调生成，维护和实验性 使用将优化实验设计，使用这些资源以及 整合所有项目和核心，以有效地加速该计划的目标。 核心的目的是：1）通过提供协作和集成，通过提供 组织和行政支持； 2）促进科学交流，结果传播和 通讯； 3）评估和促进研究进度； 4）提供管理和财政赠款 管理; 5）确保并监视最佳实践，资源利用和协调。核心意愿 促进严格和责任，动物和人类受试者的最佳实践研究，负责 进行研究，早期研究人员的指导和指导。 AC将监视 项目和科学核心并确保已经解决了性别作为生物变量。在 摘要，行政核心将运行以在程序之间统一和协调活动 项目参与者。它将促进该计划的组织和行政管理， 为细胞和鼠标实验计划提供集中式访问和协调，并增强 项目的意义，范围和规模。该核心的服务没有复制 在克利夫兰诊所建立了核心，使该核心旨在支持P01研究人员。