Admin Core

管理核心

• 批准号: 10670319
• 负责人: Lindsay A. Farrer
• 金额: $ 169.23万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670319
• 关键词: Accounting; Address; Administrative Personnel; Advisory Committees; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ancillary Study; Applications Grants; Behavioral; Biological Markers; Boston; Brain imaging; Budgets; Clinic; Clinical; Cognitive; Collaborations; Communities; Contracts; Data; Dementia; Diagnosis; Ensure; Etiology; Faculty; Feedback; Formulation; Fostering; Framingham Heart Study; Funding; Genetic; Goals; Grant; Health; Infrastructure; Institution; Interactive Communication; International; Leadership; Magnetic Resonance Imaging; Mission; Monitor; National Heart, Lung, and Blood Institute; National Institute on Aging; Neurologic; Neuropsychological Tests; Neuropsychology; Outcome; Participant; Pathogenesis; Performance; Persons; Pilot Projects; Policies; Postdoctoral Fellow; Process; Productivity; Progress Reports; Public Health; Publications; Reporting; Research; Research Activity; Research Personnel; Research Priority; Research Support; Resources; Schedule; Science; Source; Thinking; Time; Travel; United States National Institutes of Health; Universities; University adminstration; Wages; adjudication; aging brain; cohort; data access; data resource; effectiveness evaluation; human subject; improved; innovation; medical schools; meetings; neuropathology; operation; payment; programs; success; symposium; synergism

The mission of the Framingham Heart Study–Brain Aging Program (FHS-BAP) is to conduct, facilitate and promote high impact research on the etiology, pathogenesis, diagnosis, treatment, and prevention of Alzheimer disease (AD) and related disorders. The Administrative Core serves as a focal organizational point to organize and harmonize research activities of the Clinical, Neuropsychology, and Data Cores and Projects 1-3 to maximize synergy, efficiency and productivity. In the proposed funding period, the Administrative Core will guide the extension and expansion of the rich FHS data resource and establish a management infrastructure that will greatly increase the sharing and utilization of this resource by other researchers worldwide. To accomplish these central goals, the Administrative Core will serve as the interface between internal FHS-BAP activities and external entities, and ensure that FHS-BAP activities meet all Core and project milestones and are consistent with the National Institute of Aging (NIA) AD research mission and in full compliance with all human subjects, and scientific integrity policy requirements of the NIH. We will form an External Advisory Committee (EAC) to advise on the formulation and execution of FHS-BAP priorities and proactively identify opportunities that will keep us on the forefront of forward-thinking science. Key to executing the Administrative Core's mission is to provide appropriate financial oversight of the entire FHS-BAP, track the disposition of materials provided and the outcomes of FHS-BAP supported research (publications and funded activities) and present progress in meeting the stated aims to the EAC feedback will be critical in assessing effectiveness of operational activities in meeting research priorities and their oversight and continuous input for improvements help ensure we achieve our stated goals. Additionally, consideration and coordination of FHS-BAP day-to-day operations with other FHS research programs (e.g., NHLBI funded FHS contract to support core health exams of FHS cohorts) and other ancillary studies that are collecting data from FHS participants at the FHS clinic based in Framingham, MA will be done in collaboration with an Internal Advisory Board (IAB), consisting of locally based BU faculty to better address time-sensitive logistical issues. The Administrative Core will also promote new innovative AD research using data generated by the FHS-BAP through a pilot project program that will encourage grant applications from junior faculty and postdoctoral fellows, as well as from established faculty who are new to the AD field, throughout BU and possibly other institutions. Additional efforts to foster innovative AD research will be facilitating cross-core/project interactions by promotion of collaborations between FHS-BAP investigators with local, national, and international research programs, by representing the FHS-BAP at scientific meetings and publicizing FHS-BAP data access and use through the Data Core and coordinating with the BU Alzheimer Disease Center to host seminars and symposia focused on AD research.

Framingham心脏研究 - 脑老化计划（FHS-BAP）的使命是进行，促进和 促进对阿尔茨海默氏病的病因，发病机理，诊断，治疗和预防的高影响研究 疾病（AD）和相关疾病。行政核心是组织的重点组织点 并协调临床，神经心理学以及数据核心和项目1-3的研究活动 最大化协同，效率和生产力。在拟议的资金期间，行政核心将指导 扩展和扩展丰富的FHS数据资源并建立一个管理基础架构 大大增加了全球其他研究人员对该资源的共享和利用。完成这些 中心目标，行政核心将充当内部FHS-BAP活动与 外部实体，并确保FHS-BAP活动符合所有核心和项目里程碑，并且是一致的 随着国家老化研究所（NIA）AD研究任务，并完全遵守所有人类主题， NIH的科学完整性政策要求。我们将组建一个外部咨询委员会（EAC） 就FHS-BAP优先事项的公式和执行建议，并主动确定将会 让我们处于前瞻性科学的最前沿。执行行政核心使命的关键是 提供对整个FHS-BAP的适当财务监督，跟踪提供的材料的处理和 FHS-BAP的结果支持研究（出版物和资助活动），并在 满足既定的目标对EAC反馈的目标对于评估运营活动的有效性至关重要 在满足研究的重点及其监督和持续的改进方面，有助于确保我们实现 我们陈述的目标。此外，考虑和协调FHS-BAP日常操作与其他FHS 研究计划（例如，NHLBI资助了FHS合同，以支持FHS队列的核心健康考试）和其他 正在收集位于马萨诸塞州弗雷明汉市FHS诊所的FHS参与者的辅助研究 与内部顾问委员会（IAB）合作完成，由本地的BU教师组成以更好 解决时间敏感的后勤问题。行政核心还将促进新的创新广告研究 使用FHS-BAP生成的数据通过试点项目计划，该计划将鼓励授予申请 来自初级教职员工和博士后研究员，以及来自广告领域的新教师 整个BU和可能的其他机构。促进创新广告研究的额外努力将是 通过促进FHS-BAP调查人员与与 在科学会议上代表FHS-BAP来代表本地，国家和国际研究计划 发布FHS-BAP数据访问和通过数据核心使用，并与BU Alzheimer进行协调 疾病中心举办的半小便和专题讨论会，专注于AD研究。