Core C: Translational and Transformative Research

核心 C：转化和变革研究

• 批准号: 10256006
• 负责人: TRACI C GREEN
• 金额: $ 29.34万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10256006
• 关键词: Address; Adult; Area; Behavior; Behavior Therapy; Behavioral; Businesses; Caring; Catalogs; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; Clinical Sciences; Code; Collaborations; Communication; Communities; Complement; Complex; Conflict (Psychology); Consultations; Data; Data Analyses; Data Collection; Development; Dissemination and Implementation; Educational workshop; Event; Evidence based practice; Foundations; Funding; Goals; Health Insurance Portability and Accountability Act; Healthcare; Healthcare Systems; Hospitals; Institution; Interdisciplinary Study; Intervention; Language; Lead; Leadership; Logistics; Mentors; Mentorship; Modality; Morbidity - disease rate; National Institute of Child Health and Human Development; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neighborhoods; Opiate Addiction; Overdose; Paper; Patients; Pharmaceutical Preparations; Policies; Policy Maker; Process; Protocols documentation; Publications; Qualitative Research; Records; Research; Research Assistant; Research Personnel; Research Project Grants; Resources; Rhode Island; Science; Scientist; Social Sciences; Solid; Technology; Testing; Time; Training; Translating; Translational Research; Translations; Trust; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Vendor; Vulnerable Populations; War; Work; Writing; bench to bedside; career; design; experience; hackathon; high risk; innovation; literacy; meetings; member; mortality; opioid epidemic; opioid overdose; opioid use disorder; research study; research to practice; simulation; skill acquisition; social; theories; therapy development; tool; translational approach; usability

PROJECT SUMMARY Nationally, drug overdose is the leading cause of adult accidental death, claiming more lives every year than every armed conflict since the end of the World Wars. Rhode Island is a state devastated by overdose mortality and morbidity. The enormity and urgency of the opioid epidemic call for new, translational approaches, and faster dissemination of research and promising interventions to transform the care of opioid addiction and overdose, in Rhode Island and nationwide. To maximize the impacts of such scientific findings on the behaviors of patients, clinicians, healthcare systems, and policy makers, the proposed COBRE on Opioid Addiction and Overdose needs concerted efforts and key resources to both generate and execute translational research, and to create effective study dissemination tools. Local resources to encourage and nurture translational research in the social and behavioral to clinical sciences are limited, and opportunities for skill acquisition, concept development, simulation, and user testing in translational research are not sustained over time. To better optimize the efficacy and reach of the proposed projects, resources to generate and execute translational research, and to create effective study dissemination tools are needed. The Translational and Transformative (T2) Core aims to provide expert support and technical assistance to junior investigators and affiliated researchers at Rhode Island Hospital, Brown University, and other area hospitals and institutions. The long-term goal of the T2 Core is to establish a regional and national hub of translational and transformative resources capable of supporting junior investigators, COBRE projects, and the broader scientific community as they bridge theory to promising intervention, and research to practice and policy change for opioid addiction and overdose. The Core aims are to: 1) Support the execution of high-quality translational and implementation COBRE-affiliated studies through expert consultation and data collection support on qualitative research, translating theory into intervention, and technology-driven interventions; 2) Develop a culture of excellence and innovation in translational and transformative training and research on opioid addiction and overdose by hosting annual meetings and contests, and quarterly workshops and trainings; and 3) Promote and support implementation and dissemination of COBRE-affiliated research study findings, by assisting with data presentation, plans for dissemination, and study communications. Led by experienced and highly productive researchers with extensive mentoring experience, the T2 Core will inspire innovation in translational and transformative research, and provide a valuable resource for the COBRE studies.

项目摘要 在全国范围内，药物过量是成人意外死亡的主要原因，每年的生命超过 自世界大战结束以来的每一次武装冲突。罗德岛是一个被过量摧毁的国家 死亡率和发病率。阿片类药物流行病的巨大和紧迫性要求新的转化 方法，更快地传播研究和有希望的干预措施，以改变阿片类药物的护理 在罗德岛和全国范围内，成瘾和过量。为了最大化这种科学发现的影响 关于患者，临床医生，医疗保健系统和政策制定者的行为，拟议的鞋垫 阿片类药物成瘾和过量需要一致的努力和关键资源来产生和执行 翻译研究，并创建有效的研究传播工具。鼓励和 培养社会和行为对临床科学的翻译研究是有限的，并且机会 转化研究中的技能获取，概念开发，模拟和用户测试无法持续 随着时间的推移。更好地优化拟议项目的功效和覆盖范围，生成和 执行翻译研究，并需要创建有效的研究传播工具。翻译 和变革性（T2）的核心旨在为初级调查人员提供专家支持和技术援助 以及罗德岛医院，布朗大学以及其他地区医院和机构的附属研究人员。 T2核心的长期目标是建立一个区域和国家枢纽的转化和变革性枢纽 能够支持初级调查人员，山子项目和更广泛的科学界的资源 他们将理论桥接到有前途的干预措施中，并研究阿片类药物成瘾的实践和政策变化 和用药过量。核心目的是：1）支持执行高质量的翻译和实施 通过针对定性研究的专家咨询和数据收集支持，与毛c的相关研究， 将理论转化为干预和技术驱动的干预措施； 2）发展一种卓越文化和 翻译和变革性培训和研究阿片类药物成瘾和过量研究的创新 举办年度会议和比赛，季度研讨会和培训； 3）促进和支持 通过协助数据来实施和传播毛cre相关研究的研究结果 演示，传播计划和研究沟通。由经验丰富且高产的领导 具有丰富指导经验的研究人员，T2核心将激发转化和 变革性研究，并为山毛研究提供了宝贵的资源。