Core C: Translational and Transformative Research

核心 C：转化和变革研究

• 批准号: 10711728
• 负责人: TRACI C GREEN
• 金额: $ 32.22万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711728
• 关键词: Accidents; Address; Adult; Affect; Area; Behavior; Behavior Therapy; Behavioral; Caring; Centers of Research Excellence; Cessation of life; Clinical Sciences; Collaborations; Communication; Communities; Complement; Complex; Conflict (Psychology); Consultations; Data; Data Analyses; Data Collection; Development; Dissemination and Implementation; Educational workshop; Equipment; Event; Evidence based practice; Foundations; Funding; Goals; Growth and Development function; Healthcare Systems; Hospitals; Illicit Drugs; Institution; Interdisciplinary Study; Intervention; Laboratories; Language; Leadership; Mentors; Mentorship; Morbidity - disease rate; Neighborhoods; Opiate Addiction; Opioid; Overdose; Paper; Patients; Peer Review; Pharmaceutical Preparations; Policies; Policy Maker; Prevention; Process; Productivity; Protocols documentation; Publications; Publishing; Qualitative Research; Records; Research; Research Personnel; Research Project Grants; Resources; Rhode Island; Risk; Sampling; Schools; Science; Scientist; Social Sciences; Solid; Technology; Testing; Time; Training; Translating; Translational Research; Translations; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Vulnerable Populations; War; Work; Writing; addiction; bench to bedside; career; design; experience; field study; forging; hackathon; innovation; literacy; meetings; member; mortality; novel; opioid epidemic; opioid overdose; opioid use; opioid use disorder; research study; research to practice; simulation; skill acquisition; social; social media; theories; therapy development; tool; translational approach; usability; virtual; web site

PROJECT SUMMARY Nationally, drug overdose is the leading cause of adult accidental death, claiming more lives every year than every armed conflict since the end of the World Wars. Rhode Island is a state devastated by overdose mortality and morbidity. The enormity and urgency of the opioid crisis call for new, translational approaches and faster dissemination of research and promising interventions to transform the care of opioid addiction and overdose, in Rhode Island and nationwide. To maximize the impacts of such scientific findings on the behaviors of patients, clinicians, healthcare systems, and policy makers, the COBRE on Opioids and Overdose needs concerted efforts and key resources to both generate and execute translational research and to create effective study dissemination tools. Local resources to encourage and nurture translational research in the social and behavioral to clinical sciences are limited, and opportunities for skill acquisition, concept development, simulation, and user testing in translational research are not sustained over time. To better optimize the efficacy and reach of the proposed projects, resources to generate and execute translational research and to create effective study dissemination tools are needed. The Translational and Transformative Research (T2) Core aims to continue to provide expert support and technical assistance to junior investigators and affiliated researchers at Rhode Island Hospital, Brown University, and other area hospitals and academic institutions. The long-term goal of the T2 Core is to establish a regional and national hub of translational and transformative resources capable of supporting junior investigators, COBRE projects, and the broader scientific community as they bridge theory to promising intervention and research to practice and policy change for opioid use disorder and overdose. The Core aims are to: 1) Support the execution of high-quality, impactful translational and implementation COBRE-affiliated studies through expert consultation and data collection support on qualitative research, translating theory into intervention, laboratory testing supports, and technology-driven interventions; 2) Develop a culture of excellence and innovation in translational and transformative training and research on opioid use and overdose by hosting annual meetings and contests and quarterly workshops and trainings; and 3) Promote and support implementation and dissemination of COBRE- affiliated research study findings by assisting with data presentation, plans for dissemination, and study communications, including to vulnerable populations and affected communities. Led by experienced and highly productive researchers with extensive mentoring experience, the T2 Core will inspire innovation in translational and transformative research and provide a valuable resource for the COBRE studies.

项目摘要 在全国范围内，药物过量是成人意外死亡的主要原因，每年的生命超过 自世界大战结束以来的每一次武装冲突。罗德岛是一个被过量摧毁的国家 死亡率和发病率。阿片类药物危机的巨大和紧迫性要求采取新的翻译方法 以及更快地传播研究和有希望的干预措施，以改变阿片类药物成瘾和 过量服用，在罗德岛和全国。为了最大化这种科学发现对 患者，临床医生，医疗保健系统和政策制定者的行为，阿片类药物和过量的毛病 需要一致的努力和关键资源来生成和执行翻译研究并创建 有效的研究传播工具。当地资源鼓励和培育转化研究 临床科学的社会和行为是有限的，技能掌握的机会，概念 随着时间的流逝，转化研究中的开发，仿真和用户测试无法维持。更好 优化拟议项目的功效和触及范围，生成和执行翻译的资源 需要研究并创建有效的研究传播工具。翻译和变革性 研究（T2）核心旨在继续为初级调查人员提供专家支持和技术援助 以及罗德岛医院，布朗大学以及其他地区医院和学术的研究人员 机构。 T2核心的长期目标是建立一个区域和民族转化枢纽 能够支持初级调查人员，山子项目和更广泛科学的变革性资源 社区在培养理论以进行有希望的干预和研究以实践和政策变革的过程中 阿片类药物使用障碍和过量。核心目的是：1）支持高质量，有影响力的执行 通过专家咨询和数据收集的转化和实施苏布尔相关研究 对定性研究的支持，将理论转化为干预，实验室测试支持以及 技术驱动的干预措施； 2）发展一种卓越和创新的文化 通过举办年度会议和竞赛以及 季度研讨会和培训； 3）促进和支持cobre的实施和传播 附属研究的发现，通过协助数据显示，传播计划和研究 通讯，包括弱势群体和受影响的社区。由经验丰富的领导 具有丰富指导经验的生产研究人员，T2核心将激发转化的创新 和变革性研究，并为毛病研究提供了宝贵的资源。