Core C: Translational and Transformative Research

核心 C：转化和变革研究

• 批准号: 10006599
• 负责人: TRACI C GREEN
• 金额: $ 35.76万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006599
• 关键词: Address; Adult; Area; Behavior; Behavior Therapy; Behavioral; Businesses; Caring; Catalogs; Centers for Disease Control and Prevention (U.S.); Centers of Research Excellence; Cessation of life; Clinical Sciences; Code; Collaborations; Communication; Communities; Complement; Complex; Conflict (Psychology); Consultations; Data; Data Analyses; Data Collection; Development; Educational workshop; Event; Evidence based practice; Foundations; Funding; Goals; Health Insurance Portability and Accountability Act; Healthcare; Healthcare Systems; Hospitals; Institution; Interdisciplinary Study; Intervention; Language; Lead; Leadership; Logistics; Mentors; Mentorship; Modality; Morbidity - disease rate; National Institute of Child Health and Human Development; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neighborhoods; Opiate Addiction; Overdose; Paper; Patients; Pharmaceutical Preparations; Policies; Policy Maker; Process; Protocols documentation; Publications; Qualitative Research; Records; Research; Research Assistant; Research Personnel; Research Project Grants; Resources; Rhode Island; Science; Scientist; Social Sciences; Solid; Technology; Testing; Time; Training; Translating; Translational Research; Translations; Trust; United States Agency for Healthcare Research and Quality; United States National Institutes of Health; Universities; Vendor; Vulnerable Populations; War; Work; Writing; bench to bedside; career; design; dissemination research; experience; hackathon; high risk; innovation; literacy; meetings; member; mortality; opioid epidemic; opioid overdose; opioid use disorder; research study; research to practice; simulation; skill acquisition; social; theories; therapy development; tool; translational approach; usability

PROJECT SUMMARY Nationally, drug overdose is the leading cause of adult accidental death, claiming more lives every year than every armed conflict since the end of the World Wars. Rhode Island is a state devastated by overdose mortality and morbidity. The enormity and urgency of the opioid epidemic call for new, translational approaches, and faster dissemination of research and promising interventions to transform the care of opioid addiction and overdose, in Rhode Island and nationwide. To maximize the impacts of such scientific findings on the behaviors of patients, clinicians, healthcare systems, and policy makers, the proposed COBRE on Opioid Addiction and Overdose needs concerted efforts and key resources to both generate and execute translational research, and to create effective study dissemination tools. Local resources to encourage and nurture translational research in the social and behavioral to clinical sciences are limited, and opportunities for skill acquisition, concept development, simulation, and user testing in translational research are not sustained over time. To better optimize the efficacy and reach of the proposed projects, resources to generate and execute translational research, and to create effective study dissemination tools are needed. The Translational and Transformative (T2) Core aims to provide expert support and technical assistance to junior investigators and affiliated researchers at Rhode Island Hospital, Brown University, and other area hospitals and institutions. The long-term goal of the T2 Core is to establish a regional and national hub of translational and transformative resources capable of supporting junior investigators, COBRE projects, and the broader scientific community as they bridge theory to promising intervention, and research to practice and policy change for opioid addiction and overdose. The Core aims are to: 1) Support the execution of high-quality translational and implementation COBRE-affiliated studies through expert consultation and data collection support on qualitative research, translating theory into intervention, and technology-driven interventions; 2) Develop a culture of excellence and innovation in translational and transformative training and research on opioid addiction and overdose by hosting annual meetings and contests, and quarterly workshops and trainings; and 3) Promote and support implementation and dissemination of COBRE-affiliated research study findings, by assisting with data presentation, plans for dissemination, and study communications. Led by experienced and highly productive researchers with extensive mentoring experience, the T2 Core will inspire innovation in translational and transformative research, and provide a valuable resource for the COBRE studies.

项目概要 在全国范围内，吸毒过量是成人意外死亡的主要原因，每年夺去的生命比 自世界大战结束以来的每一次武装冲突。罗德岛州是一个因吸毒过量而遭受重创的州 死亡率和发病率。阿片类药物流行病的严重性和紧迫性需要新的转化方法 方法，以及更快地传播研究和有希望的干预措施，以改变阿片类药物的护理 在罗德岛州和全国范围内，药物成瘾和药物过量。最大限度地发挥此类科学发现的影响 关于患者、临床医生、医疗保健系统和政策制定者的行为，拟议的 COBRE 阿片类药物成瘾和过量需要共同努力和关键资源来生成和执行 转化研究，并创建有效的研究传播工具。鼓励和利用当地资源 培育社会和行为到临床科学的转化研究是有限的，并且机会 转化研究中的技能获取、概念开发、模拟和用户测试没有持续下去 随着时间的推移。为了更好地优化拟议项目的功效和范围，产生和利用资源 需要执行转化研究并创建有效的研究传播工具。翻译性的 变革（T2）核心旨在为初级研究人员提供专家支持和技术援助 以及罗德岛医院、布朗大学和其他地区医院和机构的附属研究人员。 T2核心的长期目标是建立一个区域和国家转化和变革中心 能够支持初级研究人员、COBRE 项目和更广泛的科学界的资源 他们将理论与有前途的干预措施、研究与阿片类药物成瘾的实践和政策变化联系起来 和过量。核心目标是： 1) 支持高质量翻译和实施的执行 COBRE 附属研究通过专家咨询和定性研究数据收集支持， 将理论转化为干预措施，以及技术驱动的干预措施； 2) 发展卓越文化 关于阿片类药物成瘾和过量的转化和变革培训和研究的创新 举办年度会议和竞赛，以及季度研讨会和培训； 3) 推广和支持 通过数据协助实施和传播 COBRE 附属研究结果 演示、传播计划和研究交流。由经验丰富且高效的领导 T2 Core 将激发具有丰富指导经验的研究人员在转化和 变革性研究，并为 COBRE 研究提供宝贵资源。