Brain-Computer Interface Implant for Severe Communication Disability

用于治疗严重沟通障碍的脑机接口植入物

• 批准号: 10250338
• 负责人: NATHAN E CRONE
• 金额: $ 60.69万
• 依托单位: UNIVERSITY MEDICAL CENTER UTRECHT
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10250338
• 关键词: Academic Medical Centers; Achievement; Address; Advanced Development; Algorithms; Area; Articulation; Attention; Baltimore; Basic Science; Blinking; Brain; Caregivers; Clinical; Clinical Treatment; Cognition Disorders; Cognitive; Communication; Communication Disability; Communication impairment; Computer software; Computers; Devices; Diagnostic; Electrodes; Electrophysiology (science); Ensure; Environment; Epilepsy; Eye; Eye Movements; Face; Family; Feasibility Studies; Freedom; Frequencies; Friends; Future; Generations; Gestures; Goals; Hand; Home; Hospitals; Human; Implant; Journals; Knowledge; Learning; Left; Letters; Locked-In Syndrome; Medicine; Motor; Motor Cortex; Netherlands; Neurosciences; New England; Operative Surgical Procedures; Outcome Measure; Paralysed; Participant; Patient Recruitments; Patients; Pattern; Performance; Positioning Attribute; Privacy; Publishing; Quality of life; Reporting; Research; Route; Scientist; Signal Transduction; Speech; Speech Synthesizers; Speed; Stream; Structure; System; Tablet Computer; Techniques; Technology; Time; Training; Translating; Universities; Wireless Technology; Writing; base; brain computer interface; caregiver functioning; density; finger movement; flexibility; implantable device; improved; loved ones; nervous system disorder; neuroregulation; relating to nervous system; satisfaction; sound; source localization; spelling; vocalization

PROJECT SUMMARY / ABSTRACT Patients with Locked-In Syndrome (LIS) are cognitively intact but unable to move or communicate except through eye blinks or limited (vertical) eye movements. For many patients suffering from this predicament, self-initiated communication is no longer possible, and they are unable to start a conversation, ask a question, or draw caregiver attention. Having no other means of interacting with family or friends, these LIS patients lack privacy and any degree of independence. Recently, a Brain-Computer Interface (BCI) device was successfully implanted in a locked-in patient with late stage ALS. By modulating her brain signals, this patient was able to select letters and spell words. The breakthrough was that, for the first time, a BCI system performed well enough to enable use at home without the need for experts. This was published in the New England Journal of Medicine. Yet, the rate of spelling was only 2 characters per minute, which clearly needs to be improved. In this collaborative early-feasibility study between the University Medical Center Utrecht (The Netherlands), the Johns Hopkins University (Baltimore), and the Neuromodulation Research unit of Medtronic (Minneapolis), we will use a significantly improved version of the implant device to develop faster and more versatile BCI control techniques for home use. The overall goal of the research is 1) to prove that the basic functionality of this BCI is generalizable to other patients with LIS (AIM1), and 2) to expand current BCI capabilities through research along 3 avenues aiming to achieve A) multidimensional item selection (avenue ‘Multiselect’) that would allow patients to choose among multiple menu options, B) 2D cursor control (avenue ‘Navigate’) that would allow point-and-click use of a computer, similar to that of eye trackers for users with normal eye movements, and C) vocalization through a speech synthesizer (avenue ‘Speak’) (AIM2), which would greatly enhance communication and quality of life. A total of nine LIS patients will participate for one year each, during and after which they may continue to use the BCI system at home. An additional 16 patients with electrode grids implanted for unrelated diagnostic purposes (epilepsy surgery) will be included for the development of advanced decoding algorithms, utilizing clinical 256-channel recording systems. The study will demonstrate the feasibility of providing LIS patients with an alternative means of communication, thereby moving the current state of the art in human neuroscience to the realm of clinical treatment for severe communication disorders.

项目摘要 /摘要 锁定综合征（LIS）的患者在认知上完好无损，但无法移动或交流 通过眼睛眨眼或有限的（垂直）眼动。对于许多患有这种困境的患者 自发沟通是不再可能的，他们无法开始对话，问一个问题， 或引起照顾者的关注。这些LIS患者没有其他与家人或朋友互动的方法 缺乏隐私和任何独立性。最近，脑计算机界面（BCI）设备是 成功实施在患有晚期ALS的锁定患者中。通过调节她的大脑信号，这个患者 突破是第一次是BCI系统 表现良好，可以在家中使用，而无需专家。这是在新的 英格兰医学杂志。然而，拼写速度仅为每分钟2个字符，显然需要 要改进。在大学医学中心乌得勒支之间的这项合作的早期可行性研究中 （荷兰），约翰·霍普金斯大学（巴尔的摩）和神经调节研究部门 Medtronic（Minneapolis），我们将使用植入设备的明显改进的版本来更快地开发 以及更多用于家庭使用的多功能BCI控制技术。研究的总体目标是1）证明 该BCI的基本功能可推广到其他LIS患者（AIM1）和2），以扩大电流 BCI通过沿3条途径进行研究的BCI功能旨在实现a）多维项目选择 （“多选择”大道）将使患者在多个菜单选项中进行选择，b）2D光标控制 （“导航”大道）将允许点击使用计算机的使用，类似于目光跟踪器的使用 具有正常眼动的用户，c）通过语音合成器（大道“说话”）发声 （AIM2），这将大大增强沟通和生活质量。共有9名LIS患者将 每次参加一年，期间和之后他们可能会继续在家使用BCI系统。一个 植入无关诊断目的（癫痫手术）的16例电网患者将 使用临床256通道记录，包括用于开发高级解码算法 系统。该研究将证明为LIS患者提供另一种方法的可行性 沟通，从而将人类神经科学中最新的现状转移到临床领域 严重沟通障碍的治疗。

项目成果

Brain-Computer Interfaces for Communication: Preferences of Individuals With Locked-in Syndrome.

• DOI: 10.1177/1545968321989331
• 发表时间: 2021-03
• 期刊: Neurorehabilitation and neural repair
• 影响因子: 4.2
• 作者: Branco MP;Pels EGM;Sars RH;Aarnoutse EJ;Ramsey NF;Vansteensel MJ;Nijboer F
• 通讯作者: Nijboer F

Association between lesion location and sensorimotor rhythms in stroke - a systematic review with narrative synthesis.

• DOI: 10.1007/s10072-023-06982-8
• 发表时间: 2023-12
• 期刊: NEUROLOGICAL SCIENCES
• 影响因子: 3.3
• 作者: Kancheva, Ivana;van der Salm, Sandra M. A.;Ramsey, Nick F. F.;Vansteensel, Mariska J. J.
• 通讯作者: Vansteensel, Mariska J. J.

Towards predicting ECoG-BCI performance: assessing the potential of scalp-EEG.

预测 ECoG-BCI 性能：评估头皮脑电图的潜力。

• DOI: 10.1088/1741-2552/ac8764
• 发表时间: 2022
• 期刊: Journal of neural engineering
• 影响因子: 4
• 作者: FahimiHnazaee,Mansoureh;Verwoert,Maxime;Freudenburg,ZacharyV;vanderSalm,SandraMA;Aarnoutse,ErikJ;Leinders,Sacha;VanHulle,MarcM;Ramsey,NickF;Vansteensel,MariskaJ
• 通讯作者: Vansteensel,MariskaJ

Brain-Computer interfaces for communication: preferences of individuals with locked-in syndrome, caregivers and researchers.

• DOI: 10.1080/17483107.2021.1958932
• 发表时间: 2023-08
• 期刊: DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
• 影响因子: 2.2
• 作者: Branco, Mariana P.;Pels, Elmar G. M.;Nijboer, Femke;Ramsey, Nick F.;Vansteensel, Mariska J.
• 通讯作者: Vansteensel, Mariska J.

Stability of a chronic implanted brain-computer interface in late-stage amyotrophic lateral sclerosis.

慢性植入脑机接口在晚期肌萎缩侧索硬化症中的稳定性。

• DOI: 10.1016/j.clinph.2019.07.020
• 发表时间: 2019
• 期刊: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
• 作者: Pels,ElmarGM;Aarnoutse,ErikJ;Leinders,Sacha;Freudenburg,ZacV;Branco,MarianaP;vanderVijgh,BennyH;Snijders,TomJ;Denison,Timothy;Vansteensel,MariskaJ;Ramsey,NickF
• 通讯作者: Ramsey,NickF