University of Iowa LURN Research Site

爱荷华大学 LURN 研究基地

基本信息

批准号：
10251050
负责人：
CATHERINE S BRADLEY
金额：
$ 48.2万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-09 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10251050
关键词：
Address Adult Affect Award Behavioral Biological Biological Markers Bladder Caffeine Cellular Phone Characteristics Clinical Clinical Research Clinical Trials Cohort Studies Communities Complex Consensus Data Development Devices Disease Enrollment Ensure Food Functional disorder Funding Future Goals Health Health Personnel Intake Interdisciplinary Study Internist Intervention Iowa Irritants Knowledge Leadership Link Liquid substance Lower urinary tract Measurement Measures Methods Modeling Motor Outcome Outcome Measure Participant Patient Care Patient Monitoring Patient Outcomes Assessments Patient Self-Report Patients Phenotype Physical activity Physiological Plasma Protein Analysis Protocols documentation Publications Quality of life Reporting Research Research Infrastructure Research Personnel Sampling Self Assessment Sensory Severities Site Sleep Standardization Subgroup Symptoms Technology Testing Text Messaging Time Treatment outcome Universities Urethra Urinary Incontinence Urinary tract Urodynamics Urologic Diseases Urologist Woman Work base biomarker signature clinical care clinical infrastructure clinical research site cohort common symptom diagnosis evaluation diaries expectation experience health related quality of life improved lower urinary tract symptoms mHealth men micturition urgency multidisciplinary novel patient subsets prevent protein biomarkers recruit research clinical testing sleep quality success symptom treatment tool treatment response urinary

项目摘要

PROJECT SUMMARY/ABSTRACT Lower urinary tract symptoms (LUTS) are common and have a significant negative impact on the lives of adult men and women. The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) was formed in 2012 to address research gaps related to the care of patients with LUTS. The long-term goals of the University of Iowa LURN Research Site are to better treat and prevent lower urinary tract dysfunction in men and women. Toward this goal, additional research is required to better characterize and understand clinically-useful LUTS patient subtypes and to better measure the full patient experience related to the broad range of LUTS. The Iowa Research Site thus proposes to perform multicenter and multidisciplinary research with other LURN sites to 1) Test and refine LURN symptom-based clusters including a wider range of symptom severity and a wider range of physiological measures than performed in prior studies, 2) Assess the relationship between physical activity and sleep (important non-urologic factors related to LUTS) and LUTS and LUTS treatment response, 3) Determine phenotypic characteristics of women with LUTS by measuring the functional components via urodynamic testing, 4) Identify protein biomarker signatures contained within plasma of specific subgroups of men and women with LUTS, and 5) Validate a comprehensive outcome tool for men and women with LUTS. To address these aims, several distinct but complementary studies are proposed. LURN will perform a 3-year cohort study of men and women with a diverse spectrum of LUTS severity and characterize them with standardized clinical evaluations, self-reported symptoms and associated conditions, quality of life, voiding diaries and detailed information on treatments and treatment response over time. Wearable health tracking devices and smartphone text messaging technologies will be utilized to collect objective physical activity and sleep quality data from cohort study participants. Additionally, participants will complete the LURN Comprehensive Assessment of Self-Reported Urinary Symptoms – Outcome Measure (CASUS-OM) to test its internal consistency, validity and responsiveness to change after LUTS treatments. In another study, women with urgency and urgency urinary incontinence will undergo a battery of standardized urodynamic tests focused on sensory and motor functions of the urethra and bladder. Lastly, analysis of protein biomarker signatures will be performed, using plasma samples previously collected from men and women with LUTS. Important findings from these significant LURN research efforts will help improve the clinical care of LUTS patients and will inform the development of future LUTS clinical studies.

项目概要/摘要下尿路症状 (LUTS) 很常见，对成年人的生活有显着的负面影响下尿路功能障碍症状研究网络 (LURN) 成立于 2012 年旨在解决与 LUTS 患者护理相关的研究空白大学的长期目标。爱荷华州 LURN 研究中心的目标是更好地治疗和预防男性和女性的下尿路功能障碍。为了实现这一目标，需要进行更多研究来更好地表征和理解临床上有用的 LUTS 患者亚型，并更好地衡量与广泛的 LUTS 相关的完整患者体验。因此，爱荷华研究中心提议与其他 LURN 中心一起开展多中心、多学科研究 1) 测试和完善基于 LURN 症状的集群，包括更广泛的症状严重程度和更广泛的与之前的研究相比，生理测量的范围更广，2) 评估生理测量之间的关系活动和睡眠（与 LUTS 相关的重要非泌尿系统因素）以及 LUTS 和 LUTS 治疗反应，3) 通过测量功能成分来确定患有 LUTS 的女性的表型特征尿动力学测试，4) 识别血浆中特定亚组的蛋白质生物标志物特征患有 LUTS 的男性和女性，以及 5) 验证针对患有 LUTS 的男性和女性的综合结果工具。为了实现这些目标，LURN 将开展一项为期 3 年的多项不同但互补的研究。对具有不同 LUTS 严重程度的男性和女性进行队列研究，并用标准化临床评估、自我报告症状和相关病症、生活质量、排尿日记以及有关一段时间内治疗和治疗反应的详细信息。将利用设备和智能手机短信技术来收集客观的身体活动和此外，参与者还将完成 LURN 的睡眠质量数据。自我报告的泌尿系统症状综合评估 – 结果测量 (CASUS-OM) 以测试其在另一项研究中，女性接受了 LUTS 治疗后的内部一致性、有效性和变化反应。紧急和紧急尿失禁将接受一系列标准化尿动力学测试重点关注尿道和膀胱的感觉和运动功能最后，分析蛋白质生物标志物。将使用之前从患有 LUTS 的男性和女性身上采集的血浆样本进行签名。这些重要的 LURN 研究工作的重要发现将有助于改善 LUTS 的临床护理患者，并将为未来 LUTS 临床研究的发展提供信息。