A new tool to diagnose female urinary incontinence

诊断女性尿失禁的新工具

• 批准号: 7028666
• 负责人: CATHERINE S BRADLEY
• 金额: $ 12.58万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-27 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7028666
• 关键词: clinical research; diagnosis design /evaluation; diagnosis quality /standard; disease /disorder etiology; female; human subject; longitudinal human study; medical appointment; patient oriented research; questionnaires; self examination; sign /symptom; stress; urinary incontinence; urinary tract disorder diagnosis; women' s health

DESCRIPTION (provided by applicant): Catherine Bradley, M.D., M.S.C.E. is a full-time faculty member in the Department of Obstetrics and Gynecology at the University of Iowa. Her long-term goal is to become a successful, independent investigator focusing on patient-oriented research in female urinary incontinence (UI). She has recently completed a Master's program in Clinical Epidemiology, and she intends to pursue further formal research training, specifically in areas of questionnaire development, psychometric analyses and the use of survey data in epidemiologic studies. This award would allow her to pursue a research career development plan that includes additional advanced courses and instruction in biostatistical and epidemiologic methodology, the closely mentored completion of this research protocol, and participation in a broad range of research activities by interacting with established research groups and their ongoing projects. Dr. Bradley's immediate goals for the award period include: 1) complete coursework targeted in areas of research methodology and analysis important to this protocol; 2) further develop her critical thinking skills in clinical and epidemiologic study design and statistical analyses through the mentorship described in this application and by attending seminars and meetings; 3) become involved in multiple types of clinical and epidemiologic research, such as clinical trials and cohort studies, by working closely with her mentors at the University of Iowa and elsewhere; 4) conduct, analyze and interpret results from the proposed questionnaire development research project; 5) present research findings to the scientific community via presentations and publications; and 6) develop an area of research expertise that will lead to future study opportunities. As her main research effort, Dr. Bradley proposes to develop and test a Questionnaire for Female Urinary Incontinence Diagnosis (QUID). Her hypothesis is that a self-administered symptom-based questionnaire can accurately predict if a woman has stress and/or urge Ul. The specific aims are to measure the validity, reliability and responsiveness of the QUID. To fulfill these aims, she will complete a prospective, split-sample longitudinal study of outpatients with Ul symptoms. Criterion validity of the QUID will be tested by comparing the QUID'S diagnoses to formalized clinical diagnoses as the gold standard. Precise measurements of the QUID'S sensitivity and specificity in the diagnosis of stress and urge Ul will be performed. Reliability, reproducibility and responsiveness of the QUID will be measured. This study will produce a rigorously developed and tested questionnaire, which will be a useful diagnostic tool for clinicians and researchers who wish to accurately predict the underlying diagnoses behind female Ul symptoms. The combination of clinical and research resources available at the University of Iowa provides an ideal environment for Dr. Bradley's research career development. Dr. Bradley has the enthusiastic support of the Colleges of Medicine and Public Health, the Department of Obstetrics and Gynecologv and her mentors and collaborators.

描述（由申请人提供）：Catherine Bradley，医学博士、理学硕士是爱荷华大学妇产科的全职教员。她的长期目标是成为一名成功的独立研究者，专注于以患者为导向的女性尿失禁 (UI) 研究。她最近完成了临床流行病学硕士学位课程，打算继续接受进一步的正式研究培训，特别是在问卷开发、心理测量分析和流行病学研究中调查数据的使用等领域。该奖项将使她能够追求一项研究职业发展计划，其中包括生物统计和流行病学方法方面的额外高级课程和指导，在密切指导下完成本研究方案，以及通过与已建立的研究小组和机构互动来参与广泛的研究活动。他们正在进行的项目。 Bradley 博士在奖励期间的近期目标包括： 1) 完成针对本协议重要的研究方法和分析领域的课程； 2) 通过本申请中描述的指导以及参加研讨会和会议，进一步发展她在临床和流行病学研究设计和统计分析方面的批判性思维能力； 3) 通过与爱荷华大学和其他地方的导师密切合作，参与多种类型的临床和流行病学研究，例如临床试验和队列研究； 4) 进行、分析和解释拟议的问卷开发研究项目的结果； 5）通过演讲和出版物向科学界展示研究成果； 6) 发展一个研究专业领域，为未来的学习机会。 作为她的主要研究工作，Bradley 博士建议开发并测试女性尿失禁诊断问卷 (QUID)。她的假设是，自我管理的基于症状的问卷可以准确预测女性是否有压力和/或冲动。具体目标是衡量 QUID 的有效性、可靠性和响应性。为了实现这些目标，她将完成一项针对患有 Ul 症状的门诊患者的前瞻性、分割样本纵向研究。 QUID 标准的有效性将通过将 QUID 的诊断与作为金标准的正式临床诊断进行比较来测试。将执行QUID'S在压力和冲动UI诊断中的敏感性和特异性的精确测量。将测量 QUID 的可靠性、再现性和响应能力。这项研究将产生一份经过严格开发和测试的调查问卷，这对于希望准确预测女性 Ul 症状背后的潜在诊断的临床医生和研究人员来说将是一个有用的诊断工具。 爱荷华大学的临床和研究资源相结合，为布拉德利博士的研究职业发展提供了理想的环境。布拉德利博士得到了医学和公共卫生学院、妇产科及其导师和合作者的热情支持。