NEURAL SUBSTRATE OF INTERPERSONAL DYSFUNCTION IN BORDERLINE PERSONALITY DISORDER

边缘性人格障碍中人际功能障碍的神经基础

• 批准号: 7953732
• 负责人: ANTONIA S NEW
• 金额: $ 0.2万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953732
• 关键词: Affect; Affective; Aggressive behavior; Behavioral; Borderline Personality Disorder; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Emotional; Empathy; Event; Face; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Grant; Individual; Institution; Interpersonal Relations; Major Depressive Disorder; Methods; Monitor; Pathology; Pattern; Regulation; Research; Research Personnel; Resources; Self Destructive Behavior; Social Behavior; Social Functioning; Social Interaction; Source; Symptoms; United States National Institutes of Health; blood oxygenation level dependent response; depressed; design; experience; information processing; neural circuit; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project proposes to examine the neural circuitry underlying components of emotional information processing and social functioning in individuals with borderline personality disorder, individuals with current Major Depressive Disorder and healthy control subjects. We propose to examine affective responsiveness through a face viewing task and empathy through observing pictures and rating the experience of the people depicted in the pictures, while gathering FMRI BOLD response in event-related task designs. We will also characterize the social behavior and interpersonal interactions of all subjects with a naturalistic monitoring of social interactions using a method called "Event Contingent Recording". We will examine group differences in the two fMRI tasks and in the social interactions of the subjects. Borderline Personality Disorder (BPD) is a disabling disorder characterized by dysfunction in affect regulation and impulse control often resulting in impaired interpersonal relationships and maladaptive behavioral patterns including aggression and self-destructive behavior. Major Depressive Disorder is similar to BPD in that it involves dysphoric affect, but individuals with MDD do not tend to have the same level of interpersonal symptoms that are seen in BPD. Including individuals with both MDD and BPD will allow us to tease apart the effect of depressed affect from more fundamental borderline pathology.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目旨在检查边缘性人格障碍患者、当前重度抑郁症患者和健康对照受试者情绪信息处理和社会功能的潜在神经回路。我们建议通过面部观察任务来检查情感反应性，通过观察图片并对图片中描绘的人的经历进行评级来检查同理心，同时在事件相关的任务设计中收集 FMRI BOLD 反应。我们还将使用一种称为“事件偶然记录”的方法，通过对社交互动的自然监控来表征所有受试者的社交行为和人际互动。我们将检查两项功能磁共振成像任务和受试者社交互动中的群体差异。边缘性人格障碍（BPD）是一种致残性疾病，其特征是情感调节和冲动控制功能障碍，通常导致人际关系受损和适应不良的行为模式，包括攻击性和自毁行为。重度抑郁症与边缘性人格障碍相似，都涉及烦躁情绪，但重度抑郁症患者的人际关系症状与边缘性人格障碍不同。将同时患有重度抑郁症和边缘性人格障碍的个体纳入其中，将使我们能够将抑郁情绪的影响与更基本的边缘病理学区分开来。