REGIONAL BRAIN CONTROL OF LABORATORY INDUCED AGGRESSION AS ASSESSED BY FDG PET

通过 FDG PET 评估实验室诱发攻击的区域大脑控制

• 批准号: 7718108
• 负责人: ANTONIA S NEW
• 金额: $ 0.34万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718108
• 关键词: Aggressive behavior; Behavior; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Image; Institution; Laboratories; Measures; Patients; Pattern; Personality Disorders; Positron-Emission Tomography; Research; Research Personnel; Resources; Source; United States National Institutes of Health; mind control

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Impulsive aggression is an important clinical problem in patients with personality disorders; however, it is a difficult behavior to study in that it is an intermittent behavior. It is, therefore, essential to develop a laboratory assessment of impulsive aggression in personality disorders. In this study we propose to use a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP) to study differences in brain activation patterns using 18FDG- PET between personality disordered subjects with impulsive aggression and comparison controls. We propose to image 3 impulsive personality disorder subjects, and 3 non-impulsive comparison subjects after completion of the PSAP.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 冲动攻击是人格障碍患者的一个重要临床问题；然而，这是一种很难研究的行为，因为它是一种间歇性行为。 因此，有必要对人格障碍中的冲动攻击进行实验室评估。 在本研究中，我们建议使用攻击行为的实验室测量方法——点减法攻击范式（PSAP）来研究具有冲动攻击行为的人格障碍受试者和比较对照之间使用 18FDG-PET 的大脑激活模式的差异。 我们建议在完成 PSAP 后对 3 名冲动型人格障碍受试者和 3 名非冲动性比较受试者进行成像。