Understanding the role of dysregulation in positive affect in developmental psychopathology.

了解失调在发展精神病理学中积极影响中的作用。

• 批准号: 10572044
• 负责人: Alecia C. Vogel
• 金额: $ 19.35万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-08 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10572044
• 关键词: 10 year old; Address; Affect; Affective; Age; Aggressive behavior; Amygdaloid structure; Anterior; Behavior; Behavioral; Child; Childhood; Clinical; Data; Depressed mood; Development; Diagnostic; Diagnostics Research; Dimensions; Disease; Disruptive Behavior Disorder; Down-Regulation; Early Intervention; Early identification; Emotional; Emotions; Factor Analysis; Foundations; Fright; Functional Magnetic Resonance Imaging; Goals; Health; Impairment; Individual; Individual Differences; Infant; Intervention; Interview; Left; Literature; Manic; Measurement; Measures; Mental disorders; Mentorship; Methodology; Modeling; National Institute of Mental Health; Outcome; Parents; Patient Self-Report; Personality; Phenotype; Population; Positive Valence; Prefrontal Cortex; Prognosis; Psychopathology; Regulation; Research; Rewards; Risk; Risk Marker; Role; School-Age Population; Social Functioning; Stimulus; Strategic Planning; Symptoms; System; Temperament; Time; Training; Ulysses Contracts; Ventral Striatum; brain behavior; clinical diagnosis; developmental psychology; emotion dysregulation; emotion regulation; emotional functioning; emotional stimulus; functional MRI scan; functional disability; imaging modality; improved; longitudinal analysis; longitudinal design; negative affect; negative mood; neural correlate; pleasure; psychiatric symptom; relating to nervous system; response; study population; symptomatology

PROJECT SUMMARY Emotion dysregulation is transdiagnostic, integral to most affective and disruptive behavior disorders, and is associated with impaired functioning across domains from health to academics. The study of dysregulation of negative affect, or irritability, has resulted in a better understanding of how it predicts later impairment and general psychopathology and has identified neural correlates. However, there has been less focus on dysregulation of positive affect, despite recent evidence suggesting it contributes to the development of psychopathology, particularly externalizing symptoms, and impairment across domains from general to social functioning. Dysregulated positive affect may not only confer independent risk, but is likely to have separate underlying neural correlates, as positive and negative emotional valence systems are different domains in the Research Domains Criteria. While surgency, the temperamental measure of high positive affect, has been related to increased aggression and externalizing symptoms in infants and young children, how this relates to clinical dysregulation of positive affect, or excitability, is unknown. Moreover, the relationships between surgency and excitability with psychopathology and impairment have been largely unstudied in young children. This proposal addresses these gaps in understanding by studying the overlapping and separable contributions of surgency (normative high positive affect), excitability (clinically related dysregulated positive affect), and irritability (clinically related dysregulated negative affect) to symptoms of psychopathology and impairment in school age children. Additionally, this proposal will assess the overlap and distinctions in brain-behavior relationships between dysregulation in positive and negative affect. Specifically, 100 7-10-year-old children enriched for emotion dysregulation will be assessed using a research diagnostic interview and parent and self- report measures of emotional and general functioning at baseline and after one year. At baseline, children will undergo functional MRI scans during emotion response and regulation tasks. Consistent with the NIMH Strategic plan, particularly Strategy Objective 2, to “chart mental illness trajectories to determine when, where, and how to intervene,” understanding the separable contributions of surgency, excitability, and irritability to risk trajectories and elucidating the neural correlates of such can provide meaningful targets for early identification and intervention in multiple disorders. Under the mentorship of a diverse team of experts in emotion regulation and development, developmental psychology and psychopathology, and longitudinal and statistical methodology, the training provided through this proposal will facilitate the applicant gaining expertise in fMRI methods for studying affective processing, dimensional constructs in developmental psychopathology, and longitudinal design and analysis. This training will provide the foundational components of the applicant's long-term goals of understanding the neural and behavioral development of emotion dysregulation, specifically excitability, to inform early identification and interventions for improving emotion regulation prior to significant impairment.

项目概要 情绪失调是跨诊断的，是大多数情感性和破坏性行为障碍的组成部分，并且是 与从健康到学术等各个领域的功能受损有关。 负面情绪或烦躁，使人们更好地理解它如何预测以后的损害和 一般精神病理学并已确定神经相关性，但是，人们对这方面的关注较少。 尽管最近的证据表明积极情绪的失调有助于发展 精神病理学，特别是外化症状，以及从一般到社会领域的损害 功能失调的积极影响不仅可能带来独立的风险，而且可能具有单独的风险。 潜在的神经相关性，因为积极和消极的情绪价系统是不同的领域 研究领域标准。 与婴儿和幼儿的攻击性增加和外化症状有关，这与 此外，积极情绪或兴奋性的临床失调与手术之间的关系尚不清楚。 与精神病理学和损伤相关的兴奋性在幼儿中基本上未被研究。 提案通过研究重叠和可分离的贡献来解决这些理解上的差距 手术（规范的高积极情绪）、兴奋性（临床相关的失调积极情绪）和 烦躁（临床相关失调的负面情绪）与精神病理学症状和精神障碍 此外，该提案将评估大脑行为的重叠和区别。 具体而言，100 名 7-10 岁儿童的失调之间的关系。 将通过研究诊断访谈以及家长和自我评估来评估情绪失调的丰富性 报告基线时和一年后的情绪和一般功能测量结果。 在情绪反应和调节任务期间接受功能性 MRI 扫描，符合 NIMH 战略。 计划，特别是战略目标 2，“绘制精神疾病轨迹以确定何时、何地以及如何 进行干预”，了解急迫性、兴奋性和烦躁性对风险轨迹的不同贡献 并阐明其神经相关性可以为早期识别和识别提供有意义的目标 在情绪调节和多种疾病专家的指导下进行干预。 发展、发展心理学和精神病理学、纵向和统计方法论、 通过本提案提供的培训将有助于申请人获得功能磁共振成像方法的专业知识以进行学习 情感处理、发展精神病理学中的维度构造以及纵向设计和 该培训将为申请人的长期目标提供基本组成部分。 了解情绪失调的神经和行为发展，特别是兴奋性，以告知 在严重损害之前进行早期识别和干预以改善情绪调节。