Indiana Core Center for Clinical Research in Musculoskeletal Health

印第安纳州肌肉骨骼健康临床研究核心中心

基本信息

批准号：
10248402
负责人：
Sharon M Moe
金额：
$ 77.67万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-19 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10248402
关键词：
Achievement Affect Aging Appointment Autocrine Communication Back Basic Science Big Data Bioinformatics Biometry Bone Diseases Characteristics Chronic Disease Classification Clinical Clinical Research Clinical Trials Design Communication Communities Complex Computational algorithm Databases Development Diabetes Mellitus Diagnosis Disease Electronic Health Record Endocrine Evaluation Methodology Foundations Functional disorder Funding Genetic Genomics Genotype Goals Health Health Care Costs Healthcare Systems Human Human Subject Research Image Imaging Techniques Impairment Indiana Individual Injury Institutes Interdisciplinary Study Joints Kidney Diseases Link Malignant Neoplasms Measures Mechanics Metabolic Methodology Molecular Morphology Muscle Musculoskeletal Musculoskeletal Diseases Myopathy Osteoporosis Outcome Pain Pathogenesis Patients Phenotype Physical Function Population Precision Health Prevalence Prevention Proteomics Recording of previous events Research Research Infrastructure Research Personnel Research Project Grants Resources Sampling Services Specificity Specimen Standardization Symptoms System Technology Technology Transfer Testing Training Translational Research Twin Multiple Birth United States National Institutes of Health Universities Work bench to bedside biobank blood resource bone clinical application clinical center clinical decision-making disability imaging modality improved industry partner innovation member metabolomics molecular phenotype multidisciplinary musculoskeletal imaging new technology next generation novel nutrition personalized medicine precision medicine ranpirnase recruit sarcopenia targeted biomarker targeted treatment tissue resource

项目摘要

Musculoskeletal disorders are common and result in significant disability and health care costs. Advancements in the diagnosis and treatment of musculoskeletal disorders requires a robust clinical research infrastructure and improved classification of the various disorders. The latter is critical to precision or personalized medicine approaches as many musculoskeletal disorders have common clinical presentations of pain and impaired physical function despite diverse pathophysiology. Furthermore, research to date often focuses on bone or muscle and not how they interact. The overarching theme of the Indiana Core Center for Clinical Research (ICCCR) is to enhance clinical research in musculoskeletal disorders and to understand the muscle-bone connection by better defining, or phenotyping, this broad class of disorders in order to advance clinical research. The ICCCR will leverage campus resources of our CTSA that includes Indiana and Purdue Universities, our statewide healthcare system IU Health, the Regenstrief Institute's statewide electronic health record system, and the Precision Health Initiative to enhance clinical research. The ICCCR will work with Thematic Teams of multi-disciplinary investigators to create innovative ways to think about musculoskeletal disorder phenotypes. The ICCCR will support individuals to connect investigators and Thematic Teams to the methodologic and resource cores thereby facilitating access to and help in conducting research that 1) utilizes our vast network of electronic health records, omics, and bioinformatics group to create computable, genetic and molecular phenotypes, 2) develops standardized physical function and imaging modalities to develop functional and morphologic phenotypes, and 3) expands the Indiana Biobank's musculoskeletal tissue and blood resources. The ICCCR will work with community and industry partners to facilitate recruitment and technology transfer and provide pilot funding to support new research. These new and innovative initiatives under the ICCCR will link our musculoskeletal researchers of Indiana Center for Musculoskeletal Research to state of the art resources to identify novel targets for diagnosis and treatment of musculoskeletal disorders. We will challenge the traditional approach of bench to bedside research to instead focus on patient phenotype to bench and back research. This will improve the definition and diagnosis of the many musculoskeletal disorders to diseases that have common pathogenesis and clinical presentations, facilitating personalized medicine by focusing the right treatment for each patient.

肌肉骨骼疾病很常见，导致严重的残疾和医疗保健费用。诊断和治疗肌肉骨骼疾病的进步需要强大的临床研究基础架构和改善各种疾病的分类。后者对于精确或个性化医学方法，因为许多肌肉骨骼疾病都有常见的临床表现尽管病理生理多样化，疼痛和身体机能受损。此外，迄今为止的研究经常专注于骨头或肌肉，而不是它们相互作用的方式。印第安纳州核心中心的总体主题临床研究（ICCCR）是为了增强肌肉骨骼疾病的临床研究，并了解通过更好地定义或表型来进行这种广泛的疾病，以促进肌肉骨骨连接临床研究。 ICCCR将利用包括印第安纳州和普渡大学在内的CTSA的校园资源大学，我们的全州医疗保健系统IU Health，Regenstrief Institute的全州电子健康记录系统以及增强临床研究的精确健康计划。 ICCCR将与多学科研究人员的主题团队创建创新的方式来思考肌肉骨骼疾病表型。 ICCCR将支持个人将调查人员和主题团队与方法论和资源核心，从而促进访问并帮助进行研究1）我们庞大的电子健康记录，OMIC和生物信息学组的网络，以创建可计算的遗传和分子表型，2）发展标准化的身体功能和成像方式以发展功能性和形态学表型，以及3）扩展印第安纳生物银行的肌肉骨骼组织和血液资源。 ICCCR将与社区和行业合作伙伴合作，以促进招聘和技术转移并提供试点资金以支持新研究。这些新的创新倡议在ICCCR下，我们的印第安纳州肌肉骨骼研究中心的肌肉骨骼研究人员将最先进的资源来识别诊断和治疗肌肉骨骼疾病的新目标。我们将挑战板凳研究的传统方法，而是专注于患者表型进行替补和返回研究。这将改善许多肌肉骨骼的定义和诊断对具有常见发病机理和临床表现的疾病的疾病，促进个性化通过针对每个患者的正确治疗来进行药物。