Wireless High-Density Diffuse Optical Tomography for Decoding Brain Activity

用于解码大脑活动的无线高密度漫射光学断层扫描

• 批准号: 10244979
• 负责人: JOSEPH P CULVER
• 金额: $ 65.27万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10244979
• 关键词: 5 year old; Activities of Daily Living; Address; Adult; Affect; Algorithms; Architecture; Atlases; Attention; Auditory; Brain; Brain Mapping; Cerebral Palsy; Child; Childhood; Classification; Clinical; Cognitive; Coupled; Data; Data Set; Detection; Development; Diagnostic; Disease; Dorsal; Dyskinetic syndrome; Engineering; Family member; Fiber; Floor; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Grant; Head; Health; Image; In Situ; Individual; Infant; Intelligence; Language; Learning; Lighting; Locked-In Syndrome; Logistics; Magnetic Resonance Imaging; Maps; Modeling; Morphologic artifacts; Motion; Motor; Movement; Movement Disorders; Near-Infrared Spectroscopy; Noise; Optics; Patients; Performance; Population; Protocols documentation; Reporting; Resolution; Rest; Sensory; Software Tools; Stimulus; System; Techniques; Technology; Testing; Visual; Wireless Technology; Work; age group; aged; base; care providers; cognitive capacity; cognitive neuroscience; convolutional neural network; cortex mapping; density; design; detection sensitivity; detector; diffuse optical tomography; flexibility; improved; instrument; instrumentation; light weight; motor disorder; motor impairment; movie; neuroimaging; novel; optical imaging; pediatric patients; photonics; prevent; prognostic tool; response; spasticity; tomography; tool; visual motor; voluntary movement disorder

Project Summary This grant will develop a wireless wearable high-performance, high-density diffuse optical tomography (DOT) instrument for mapping of brain function in naturalistic settings. Functional neuroimaging of healthy adults has enabled mapping of brain function and revolutionized cognitive neuroscience. Increasingly, functional neuroimaging is being used in younger age groups, and as a diagnostic and prognostic tool in the clinical setting. Its expanding application in the study of both health and disease necessitates new, more flexible tools. The logistics of traditional functional brain scanners (e.g., fMRI) are ill-suited to many subjects. In particular, fMRI is not suited for imaging subjects who cannot lie sufficiently still in MRI scanners. In addition to young children (i.e. under 5 years old) in general, this requirement also excludes children with disorders of voluntary movement, such as moderate to severe cerebral palsy. A majority of patients with CP have either spasticity and/or dyskinesia, movement disorders that prohibits successful fMRI due to motion artifacts. A subset of CP subjects can be considered to have effectively a pediatric form of a “locked-in-syndrome”, in the sense that, while intelligence can be spared entirely, motor system dysfunction prevents the ability to speak or sign. Not uncommonly, the intellectual capacities of these children are never recognized by care-providers, educators, and family members. Thus, there are many intriguing questions in the CP population that could be addressed with functional neuroimaging, such as questions of motor plasticity and learning, perhaps the most compelling is identifying and characterizing the cognitive and neuroanatomical architecture of children with CP who are locked in. Such work could provide a path to unlocking the cognitive capacities of children with severe motor dysfunction. These studies cannot be done with fMRI. Optical imaging has long held promise as a naturalistic neuroimaging technique. Recent development of high- density diffuse optical tomography (HD-DOT), a tomographic version of fNIRS, has improved image quality dramatically. When matched within subjects against fMRI, HD-DOT now can obtain localization errors <5mm, and point spread functions <15 mm FWHM, sufficient to localize functions to gyri. While initial HD-DOT reports have been confined to simpler sensory networks (visual and motor), recent results demonstrate the feasibility of mapping distributed cognitive networks, including the dorsal attention and default mode networks. Despite these advances, application of HD-DOT to naturalistic studies has been limited by a barrier imposed by a tradeoff between coverage and wear-ability. The central photonic challenges are optical sensitivity - which would bias design towards larger/heavier fibers, and coverage - which would bias design towards a larger number of fibers. In this proposal, Aims 1-2 address the technological challenges of developing a lightweight wireless HD-DOT(WHD-DOT) system. Aim 3 develops the functional neuroimaging paradigms needed to map and decode brain function with WHD-DOT. In Aim 4, we assess the feasibility of mapping and decoding pediatric patients with cerebral palsy using WHD-DOT.

项目摘要 该赠款将开发无线可穿戴高性能，高密度弥散光学断层扫描（DOT） 在自然环境中映射大脑功能的仪器。健康成年人的功能性神经影像学 启用了大脑功能的映射并彻底改变了认知神经科学。越来越多的功能 神经影像学在年轻人组中使用，并在临床环境中用作诊断和预后工具。 它在研究健康和疾病的研究中不断扩展的应用，需要新的，更灵活的工具。 传统功能性脑扫描仪（例如fMRI）的物流不适合许多受试者。特别是，fMRI是 不适合成像无法正确地躺在MRI扫描仪中的对象。除了幼儿（即 一般来说，5岁以下），这一要求还不包括自愿运动障碍的儿童， 例如中度至重度脑瘫。大多数CP患者具有痉挛和/或 运动障碍，运动障碍，禁止因运动伪像而成功的fMRI。 CP受试者的子集 可以被认为具有有效的“锁定在混合物”的儿科形式，从某种意义上说， 智能可以完全幸免，电机系统功能障碍阻止说话或签名的能力。不是 罕见的是，这些孩子的智力能力从未被护理人员，教育工作者， 和家庭成员。那就是CP人口中有许多有趣的问题可以解决 具有功能性神经影像学，例如运动可塑性和学习问题，也许最引人注目的是 识别和表征CP锁定儿童的认知和神经解剖结构 在。这样的工作可以为解锁严重电机儿童的认知能力提供一条途径 功能障碍。这些研究不能使用fMRI进行。 长期以来，光学成像一直是一种自然主义神经影像技术。最近发展 密度弥散光学层析成像（HD点）是FNIRS的层析成像版本，已提高了图像质量 动态。当在受试者与fMRI中匹配时，HD点现在可以获得<5mm的定位错误， 点扩散函数<15 mM FWHM，足以将函数定位到Gyri。而最初的高清点报告 已局限于更简单的感觉网络（视觉和电动机），最近的结果证明了 映射分布式认知网络，包括背部注意力和默认模式网络。 尽管取得了这些进步，但在自然研究中将高清点应用于自然研究已受到障碍的限制 覆盖范围和磨损之间的权衡。中央光子挑战是光学灵敏度 - 会偏向更大/较重的纤维和覆盖范围 - 这会偏向更大的设计 纤维数。在此提案中，目标1-2解决了开发轻巧的技术挑战 无线高清点（WHD点）系统。 AIM 3开发了绘制所需的功能性神经影像范式 并用WHD点解码大脑功能。在AIM 4中，我们评估了映射和解码小儿的可行性 使用WHD点的脑瘫患者。

项目成果

Decoding visual information from high-density diffuse optical tomography neuroimaging data.

• DOI: 10.1016/j.neuroimage.2020.117516
• 发表时间: 2021-02-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Tripathy K;Markow ZE;Fishell AK;Sherafati A;Burns-Yocum TM;Schroeder ML;Svoboda AM;Eggebrecht AT;Anastasio MA;Schlaggar BL;Culver JP
• 通讯作者: Culver JP

Global motion detection and censoring in high-density diffuse optical tomography.

• DOI: 10.1002/hbm.25111
• 发表时间: 2020-10-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Sherafati A;Snyder AZ;Eggebrecht AT;Bergonzi KM;Burns-Yocum TM;Lugar HM;Ferradal SL;Robichaux-Viehoever A;Smyser CD;Palanca BJ;Hershey T;Culver JP
• 通讯作者: Culver JP

Optical imaging and spectroscopy for the study of the human brain: status report.

• DOI: 10.1117/1.nph.9.s2.s24001
• 发表时间: 2022-08
• 期刊: Neurophotonics
• 影响因子: 5.3