Medical University of South Carolina - Cancer Center Support Grant

南卡罗来纳医科大学 - 癌症中心支持补助金

• 批准号: 10243432
• 负责人: RAYMOND N. DUBOIS
• 金额: $ 15.1万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10243432
• 关键词: Academic Medical Centers; Achievement; Address; African American; Automobile Driving; Awareness; Basic Science; Biometry; Cancer Biology; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Death Rates; Cancer Research Project; Cause of Death; Cell Separation; Cells; Cervical; Cessation of life; Charge; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Colorectal; Communities; Development; Diagnosis; Diagnostic; Diet; Disease; Doctor of Philosophy; Education; Ensure; Exercise; Extramural Activities; Flow Cytometry; Fostering; Funding; Genetic; Geographic state; Geography; Goals; Head and neck structure; Healthcare; Intervention Studies; Journals; Kidney; Leadership; Lung; Malignant Neoplasms; Medical; Mission; Morbidity - disease rate; Movement; National Cancer Institute; Nature; Oncology; Outcome; Outreach Research; Participant; Patient Care; Patients; Peer Review; Physicians; Policies; Population; Population Heterogeneity; Population Research; Population Sciences; Prevention; Prevention approach; Preventive; Prostate; Public Policy; Publications; Research; Research Infrastructure; Research Personnel; Resources; Rural; Rural Community; Science; Scientific Advances and Accomplishments; Scientist; Services; Shapes; South Carolina; Strategic Planning; Technology; Therapeutic; Therapeutic Clinical Trial; Thinking; Tissues; Tobacco use; Training; Translating; Translational Research; Translations; Universities; Ursidae Family; Work; anticancer research; base; bench to bedside; biobank; cancer care; cancer education; cancer health disparity; cancer prevention; cancer therapy; career; career development; cellular imaging; community based participatory research; ethnic minority population; high school; improved; innovation; interdisciplinary collaboration; lifestyle factors; malignant breast neoplasm; medically underserved; molecular imaging; mortality; multidisciplinary; next generation; novel strategies; operation; outreach; prevent; programs; racial disparity; racial minority; ranpirnase; recruit; socioeconomics; translational pipeline; tumor immunology

OVERALL: SUMMARY The Hollings Cancer Center (HCC) at the Medical University of South Carolina (MUSC) seeks renewal of its National Cancer Institute (NCI) designation via the P30 Cancer Center Support Grant (CCSG) mechanism. As South Carolina's (SC) leading academic medical center, MUSC is charged with building basic, translational, clinical, and population-based research programs that address the state's significant healthcare needs. The mission of the HCC is to reduce the cancer burden in SC through transformative research, patient care, prevention, and public policy. To accomplish this mission, HCC leadership built a robust, multidisciplinary center that includes 107 cancer scientists. Innovative, high-impact research is driven by HCC’s four research programs: Cancer Biology, Cancer Immunology, Developmental Cancer Therapeutics, and Cancer Control. The rapid pace of discovery and movement toward effective translational research is supported by five shared research resources: Lipidomics, Flow Cytometry & Cell Sorting, Cell & Molecular Imaging, Biorepository & Tissue Analysis, and Biostatistics. During the current project period, the HCC successfully leveraged CCSG funding and its NCI-designated cancer center status to harness, expand and improve the center’s research capabilities to decrease the state’s cancer burden. HCC supported recruitment of 26 new cancer scientists. The annual direct peer-reviewed extramural research funding (excluding training and career development awards) increased to $21.6M, with $10.5M from NCI. HCC boasts the state’s largest clinical trials operation that provides centralized support for conducting the most contemporary cancer trials. During the past year, the HCC recruited 1,266 patients to interventional studies and 254 patients to non-interventional studies. HCC made significant progress in overcoming the challenges inherent in recruiting racial and ethnic minorities to participate in research. In 2017, 33% of research participants were racial or ethnic minorities, with more than half residing in rural communities federally designated as medically underserved. This progress has been maintained for over two decades by progressive, HCC-led outreach, community engagement, and cancer education services. With the charge of training the next generation of diverse and exceptional cancer physicians and scientists, the center developed the state’s only comprehensive cancer education pipeline for learners across the entire education continuum, from high school through early professional career development. The HCC is committed to providing access to the latest research, educational, and clinical advances to all of South Carolina, and has never been better equipped to fulfill its mission. Led by a new center director appointed in 2017, the HCC will implement its 2023 strategic plan to advance scientific discovery, make impactful contributions to the understanding of cancer biology in a diverse population, and translate discoveries into transformative approaches to cancer control, diagnosis, treatment, and public policy.

总体：摘要 南卡罗来纳州医科大学（MUSC）的Hollings癌症中心（HCC）寻求续签 国家癌症研究所（NCI）通过P30癌症中心支持补助金（CCSG）机制指定。作为 MUSC南卡罗来纳州（SC）领先的学术医学中心负责建设基本，翻译， 临床和基于人群的研究计划，以满足该州巨大的医疗保健需求。 HCC的任务是通过变革性研究，患者护理，减少SC中的癌症伯嫩 预防和公共政策。为了完成这项任务，HCC领导层建立了强大的多学科 包括107位癌症科学家的中心。创新的高影响力研究是由HCC的四项研究驱动的 计划：癌症生物学，癌症免疫学，发育性癌症治疗和癌症控制。 五个共享 研究资源：脂质组学，流式细胞仪和细胞分选，细胞和分子成像，生物座和 组织分析和生物统计学。在当前项目期间，HCC成功利用了CCSG 资金及其NCI指定的癌症中心地位，扩展和改善该中心的研究 减少该州癌症伯宁的能力。 HCC支持招募26位新的癌症科学家。 年度直接同行评审的校外研究资金（不包括培训和职业发展 奖项）增加到2160万美元，来自NCI的1050万美元。 HCC拥有该州最大的临床试验操作 这为进行最现代的癌症试验提供了集中的支持。在过去的一年中 HCC招募了1,266例干预研究患者，254名患者进行了非惯例研究。 HCC 在克服招募种族和少数民族固有的挑战方面取得了重大进展 参与研究。 2017年，33％的研究参与者是种族或少数民族，超过 一半居住在联邦政府指定为医疗服务不足的粗糙社区中。这个进展一直是 由进步，HCC领导的外展，社区参与和癌症维持了二十年 教育服务。负责训练下一代多样的和杰出的癌症 该中心的医师和科学家开发了该州唯一的全面癌症教育管道 从高中到早期职业的整个教育连续性学习者 发展。 HCC致力于提供最新研究，教育和临床的访问权限 前进到整个南卡罗来纳州，从未有能力履行其任务的能力。由新的 HCC于2017年任命的中心主任将实施其2023年战略计划，以推动科学发展 发现，对潜水员人群中对癌症生物学的理解做出有影响力的贡献，以及 将发现转化为癌症控制，诊断，治疗和公共政策的变革性方法。