Children's Oncology Group NCORP Research Base

儿童肿瘤学组NCORP研究基地

• 批准号: 10247181
• 负责人: BRAD H POLLOCK
• 金额: $ 44.97万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10247181
• 关键词: Acute; Acute Myelocytic Leukemia; Address; Adolescent; Adolescent and Young Adult; Adult; Aftercare; Age; Brain Stem Glioma; Canada; Cancer Center; Cancer Control; Cancer Etiology; Caring; Characteristics; Child; Childhood; Clinical Medicine; Clinical Research; Clinical Trials; Collaborations; Communities; Community Clinical Oncology Program; Community Participation; Complication; Country; Disadvantaged; Disease; Dose; Ensure; Functional disorder; Goals; Hormonal; Infant; Information Technology; Infrastructure; Institution; Interdisciplinary Study; Intervention; Laboratory Research; Late Effects; Leadership; Malignant Childhood Neoplasm; Malignant Neoplasms; Minority; Mission; Monitor; Morbidity - disease rate; Neuroblastoma; Operative Surgical Procedures; Organ; Outcome; Pathology; Patients; Pediatric Hospitals; Pediatric Oncology; Pediatric Oncology Group; Persons; Population Heterogeneity; Positioning Attribute; Prevention; Prevention strategy; Radiation Oncology; Research; Research Personnel; Resources; Second Primary Cancers; Site; Survival Rate; Symptoms; System; Therapeutic; Therapeutic Trials; Time; Tissues; Translating; Treatment-related toxicity; Universities; Work; anticancer research; base; cancer care; cancer therapy; care delivery; childhood cancer survivor; community based participatory research; data management; data quality; design; effective therapy; experience; follow-up; health care delivery; health care service organization; health disparity; health related quality of life; high risk; improved; improved outcome; member; mortality; novel; optimal treatments; outcome forecast; prevent; programs; reproductive; research study; side effect; survivorship; underserved minority; young adult

Project Summary The prognosis for children with cancer has improved dramatically over the past decades with an overall 5-year survival rate now at 84%. However, the late effects of cancer treatment, including permanent organ and tissue damage, hormonal and reproductive dysfunction and second cancers, are of special concern, with more than 40% of the estimated 360,000 survivors of childhood cancer experiencing a significant health-related quality of life complication from childhood cancer and its treatment. In addition, progress for a number of childhood cancers remains limited with approximately 50% of children with acute myelogenous leukemia, 50% of children with high-risk neuroblastoma, and more than 90% of children with brainstem glioma, still succumbing to their disease. The Children’s Oncology Group (COG), the world’s largest organization devoted exclusively to childhood and adolescent cancer research, and its multidisciplinary research teams comprised of more than 9,000 members, conducts research at more than 220 leading children’s hospitals, universities, and cancer centers. This proposal is for the COG NCI Community Oncology Research Program (NCORP) Research Base to continue its collaborative research work for our 26 community and 16 minority/underserved NCORP sites. With COG’s significant scientific, statistical, data management and information technology infrastructure, we seek to conduct pediatric clinical trials to define optimal treatments, and conduct laboratory research that will translate into more effective treatments with reduced side effects. The COG directly addresses the NCORP goals of providing access to state-of-the-art cancer treatment at community sites while conducting research in cancer control, including post-treatment surveillance/survivorship, and cancer care delivery. We promote the participation of community-based investigators in all of COG’s research, governance and administration and in NCORP Network activities. The COG’s research goals are to reduce overall mortality and morbidity, decrease acute and delayed treatment-related toxicities, and develop more effective ways of delivering care to children, adolescents and young adults. The COG NCORP Research Base is uniquely positioned to elucidate the impact of different health care delivery characteristics on outcomes, to identify determinants of poorer outcomes in underserved groups including adolescents and young adults, and to develop targeted strategies aimed at eliminating disparities and improving efficiencies for the delivery of cancer care in young persons with cancer.

项目摘要 在过去的几十年中，癌症儿童的预后急剧改善，总体5年 现在的生存率为84％。但是，癌症治疗的后期作用，包括永久器官和组织 损害，荷尔蒙和生殖功能障碍和第二癌的损害特别关注，超过 估计的360,000次儿童癌症冲浪者中有40％经历了与健康相关的大量质量 儿童癌症及其治疗的生活并发症。此外，许多童年癌的进展 约有50％的儿童患有急性骨髓性白血病，有50％的儿童仍有限制 高危神经母细胞瘤，超过90％的脑干神经胶质瘤儿童仍然屈服于他们的疾病。 儿童肿瘤学小组（COG），全球最大的组织专门致力于童年和 青少年癌症研究及其多学科研究团队完成了9,000多名成员， 在220多个领先的儿童医院，大学和癌症中心进行研究。这个建议 用于COG NCI社区肿瘤研究计划（NCORP）研究基础，以继续其 我们的26个社区和16个少数民族/服务不足的NCORP网站的协作研究工作。与COG的 大量的科学，统计，数据管理和信息技术基础设施，我们试图进行 儿科临床试验以定义最佳治疗，并进行实验室研究，以转化为更多 有效治疗副作用减少。 COG直接解决了提供的NCORP目标 在进行癌症控制研究的同时，可以在社区场所获得最先进的癌症治疗， 包括治疗后的监视/生存和癌症护理。我们促进参与 COG的所有研究，治理和管理以及NCORP网络中的基于社区的研究人员 活动。 COG的研究目标是降低总体死亡率和发病率，减少急性并延迟 与治疗有关的毒性，并开发更有效的方法来为儿童，青少年和 年轻人。 COG NCORP研究基础是唯一的定位，以阐明不同健康的影响 有关结果的护理交付特征，以确定服务不足的组的结果较差 包括青少年和年轻人，并制定旨在消除差异和 提高癌症年轻人提供癌症护理的效率。