Laboratory of Developmental Biology

发育生物学实验室

• 批准号: 10238806
• 负责人: Ian Amos Glass
• 金额: $ 78.62万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-05-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10238806
• 关键词: Atlases; Awareness; Barker Hypothesis; Biomedical Research; Brain; Cancer Biology; Cells; Clinic; Clinical; Collaborations; Collection; Communities; Congenital Abnormality; Custom; Development; Developmental Biology; Disease; Drug or chemical Tissue Distribution; Enrollment; Ensure; Epigenetic Process; Ethics; Expenditure; Experimental Designs; Fetal Development; Fetal Tissues; Fetus; Fostering; Funding; Future; Genetic; Genetic Diseases; Genomics; Goals; Guidelines; Healthcare; Human; Human Biology; Human Development; Immune System Diseases; Inflammatory; Institution; Laboratories; Laboratory Research; Logistics; Methods; Nature; Organ; Outcomes Research; Procedures; Process; Protocols documentation; Provider; Regenerative Medicine; Regulation; Research; Research Personnel; Resources; Sampling; Services; Shipping; Ships; Source; Specimen; Staging; Suspensions; Termination of pregnancy; Time; Tissue Banks; Tissue imaging; Tissues; United States National Institutes of Health; Universities; Work; base; biomedical scientist; cell repository; cellular imaging; design; epigenomics; fetal; human disease; improved; innovation; news; next generation sequencing; novel; novel strategies; preservation; pressure; programs; quality assurance; rare cancer; recruit; repository; sound; success

PROJECT SUMMARY/ABSTRACT In existence for more than 50 years, the Birth Defects Research Laboratory (BDRL) is now the only NIH- funded fetal tissue repository available to scientific recipients in the US. It is therefore a crucial scientific resource to retain for facilitating biomedical research, especially since alternative commercial laboratories are embroiled in controversy related to accusations of trade in fetal tissues. The scientific importance of fetal tissues to scientific research progress and health care is highlighted in a recent high profile Nature news-feature article (PMID 26659164). In fiscal year 2014, NIH funded 164 projects that utilized fetal tissues for a total expenditure of $76 million, with our laboratory as the only NIH fetal tissue repository, being the primary resource for many of these projects. The track record and success of the BDRL has therefore been proven many times over in its consistent provision of a host of scientific recipient-related services with fetal tissues, fully compliant with strict ethical and research guidelines, without misdemeanor. Spectacular technological advances in epigenetics, genomics, cellular and tissue imaging, and developmental biology have greatly expanded research opportunities for utilizing these precious tissues to facilitate current and future biomedical research progress. These advances establish the rationale for the laboratory to innovate and undertake multiple collaborations to both evaluate and demonstrate the utility of novel experimental approaches to maximize the scientific utility of these tissues. This application seeks to develop the resource beyond the core fundamental goal of the resource aka the systematic collection, staging, identification and processing of fetal specimens for distribution of tissues and derivatives to scientific recipients. We, therefore, propose to develop the research resource utility further by engaging with key collaborators to synergistically develop new services and thereby concurrently promote scientific awareness of these approaches to increase recipient recruitment and enhance research progress into the bases of human development and disease.

项目摘要/摘要 出生缺陷研究实验室（BDRL）现在已经存在了50多年，现在是唯一的NIH- 美国科学接受者可用于资助的胎儿组织存储库。因此，这是一个至关重要的科学 保留促进生物医学研究的资源，尤其是因为替代商业实验室 卷入与指控胎儿组织贸易有关的争议。科学的重要性 最近的备受瞩目 新闻节目文章（PMID 26659164）。在2014财政年度，NIH资助了164个利用胎儿的项目 总支出为7600万美元的组织，我们的实验室是唯一的NIH胎儿组织存储库 是许多这些项目的主要资源。 BDRL的往绩和成功 因此，在一致提供了许多与科学接收者有关 胎儿组织的服务，完全符合严格的道德和研究指南，而没有轻罪。 表观遗传学，基因组学，细胞和组织成像的壮观技术进步以及 发育生物学大大扩大了利用这些珍贵组织的研究机会 促进当前和未来的生物医学研究进步。这些进步确定了 实验室进行创新和进行多次合作，以评估和证明 新型的实验方法，以最大化这些组织的科学效用。本申请寻求 开发资源超出资源的核心基本目标，也就是系统收藏， 胎儿标本的分期，鉴定和处理，用于分布组织和衍生物 科学接受者。因此，我们建议通过参与进一步发展研究资源实用性 有了主要的合作者，可以协同开发新服务，从而同时促进科学 对这些方法的意识，以增加接受者招聘并增强研究进步 人类发展和疾病的基础。