LABORATORY OF DEVELOPMENTAL BIOLOGY

发育生物学实验室

• 批准号: 7762234
• 负责人: Ian Amos Glass
• 金额: $ 57.91万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-05-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7762234
• 关键词: Advertising; American; Area; Autolysis; Biomedical Research; Birth; Clinic; Collection; Congenital Abnormality; Databases; Development; Developmental Biology; Digoxin; Distant; Drug or chemical Tissue Distribution; Ensure; European; Evaluation; Fetus; Funding; Genomics; Grant; Growth and Development function; Human; Human Development; Image; Institution; Japanese Population; Laboratories; Laboratory Research; Laboratory Study; Letters; Maintenance; Medical; Operative Surgical Procedures; Optics; Organ; Pregnancy; Procedures; Progress Reports; Protocols documentation; Publications; Publishing; Reporting; Research; Research Activity; Research Ethics Committees; Research Personnel; Resources; Sampling; Security; Services; Shipping; Ships; Site; Slide; Societies; Specimen; Staging; Stem cells; System; Teratology; Time; Tissue Sample; Tissues; Training Programs; Translational Research; United States National Institutes of Health; Universities; Washington; abortion; experience; interest; meetings; member; pediatrician; prenatal; programs; stem cell biology; tomography; web site

DESCRIPTION (provided by applicant): The Birth Defects Research Laboratory, funded by the NIH for 45 years, is the major national resource for collection and distribution of human conceptal tissue to grant-funded investigators at universities and nonprofit institutions nationwide. The Laboratory has collected approximately 22,000 specimens to-date, and its importance is highlighted by the fact that distribution continues to increase, with 330 investigators supplied during the past seven years, compared with 171 in the prior grant cycle. Research on tissues provided during this period resulted in nearly 500 reported publications, compared with 120 previously. Recent progress in stem cell biology, developmental genomics, translational research, and other active areas in biomedical research have made the investigators' ability to reliably provide conceptal tissue in a scientifically controlled and IRB approved manner more valuable than ever. Changes in termination practice, including newer medical, non-surgical procedures, and the use of agents to ensure delivery of nonviable specimens, have created new obstacles to obtaining sufficient amounts of high quality tissue required for research. To overcome these problems and meet increasing demand, the Laboratory has developed new relationships with both local and distant clinics. Additionally, the efficiency and expertise of the experienced staff enables the Laboratory to maximize the samples retrieved from each specimen. New initiatives include an emphasis on supplying and collaborating with stem cell investigators at the University of Washington and other institutions, as well as increasing total distribution. To this end, the investigators have formed and convened an advisory board for the Laboratory and plan to attend several scientific meetings annually to highlight our services to interested investigators. They also plan to develop a website for tissue recipients and utilize their electronic database to assure the quality of tissue samples. Finally, they propose to explore the utility of a new imaging system, Optical Projection Tomography, to the Laboratory program.

描述（由申请人提供）：由NIH资助了45年的先天缺陷研究实验室，是全国人类概念组织收集和分配人类概念组织的主要资源，以授予全国大学和非营利机构的授予资助的研究人员。 该实验室已经收集了大约22,000个标本，迄今为止，其重要性是由于分配不断增加的事实强调了，在过去七年中提供了330名调查人员，而先前的赠款周期中有171个调查人员。 对此期间提供的组织的研究导致了近500个报告的出版物，而先前的120个出版物。 干细胞生物学，发育基因组学，转化研究和生物医学研究中其他活跃领域的最新进展使研究人员能够以科学控制和IRB批准的方式可靠地提供概念组织，比以往任何时候都更有价值。 终止实践的变化，包括新的医学，非手术程序，以及使用代理来确保提供不可行的标本，为获得足够数量的研究所需的高质量组织带来了新的障碍。 为了克服这些问题并满足日益增长的需求，实验室已经与地方和遥远的诊所建立了新的关系。 此外，经验丰富的员工的效率和专业知识使实验室能够最大程度地从每个标本中检索出样品。 新的举措包括强调与华盛顿大学和其他机构的干细胞研究人员提供和合作，以及增加总分布。 为此，调查人员已经成立并召集了一个实验室的顾问委员会，并计划每年参加几次科学会议，以突出我们向感兴趣的调查人员提供服务。 他们还计划开发一个用于组织接受者的网站，并利用其电子数据库来确保组织样品的质量。 最后，他们建议探索实验室计划的新成像系统（光学投影断层扫描）的实用性。