Health Disparities in Alzheimers and Related Diseases

阿尔茨海默病和相关疾病的健康差异

• 批准号: 10238143
• 负责人: Jason R Richardson
• 金额: $ 4.94万
• 依托单位: FLORIDA INTERNATIONAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10238143
• 关键词: Address; Affect; African American; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Attention; Basic Science; Brain; Calibration; Clinical Research; Clinical Trials; Communication; Communities; Demographic Factors; Development; Device or Instrument Development; Diabetes Mellitus; Diet; Disease; Education; Enrollment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Epigenetic Process; Ethnic Origin; Ethnic group; Family; Florida; Genes; Genetic; Genetic Risk; Goals; Health; Hormonal; Income; Individual; Interdisciplinary Study; International; Intervention; Knowledge; Late Onset Alzheimer Disease; Latino; Life Style; Longevity; Measurement; Mediating; Mental Health; Metabolic; Methods; Minority; Minority Groups; Modeling; Modification; Morbidity - disease rate; Neurodegenerative Disorders; Neurosciences; Occupational; Paper; Pathology; Pathway interactions; Patients; Peer Review; Pharmacology; Population; Predisposition; Process; Public Health; Publications; Race; Recording of previous events; Reporting; Research; Respondent; Rest; Risk; Science; Scientist; Series; Sex Differences; Theoretical model; Therapeutic Intervention; Time; Toxicant exposure; Training; Translational Research; Underrepresented Populations; United States; Universities; Vascular Diseases; Woman; Work; base; comorbidity; dementia risk; ethnic minority population; gene environment interaction; health disparity; high risk; improved; innovation; instrument; lifestyle factors; lifetime risk; model development; precision medicine; programs; sex; social; social factors; sociodemographic factors; symposium; theories; therapy development

This application from Florida International University (FIU) and Emory University requests support for a four-year research conference series to address critical scientific issues associated with reducing Alzheimer's Disease and Related Dementia (ADRD) inequities among ethnic minorities in the United States. The conference series we propose rests on interdisciplinary research using a population disease framework, with specific attention to ethnic groups and sex differences in pathways to neurodegenerative diseases. Genetics and family/personal health histories are non-modifiable factors, and modifiable factors include a wide range of lifespan environmental exposures and lifestyle factors. The conference series focuses on increasing understanding about how genetic factors are operating in concert with environmental exposures, family and personal health histories, and lifestyle factors to produce interactions that enhance or mitigate risk of ADRD within and between ethnic groups, specifically among African Americans, Latinos, and non-Latino Whites. These critical issues remain largely overlooked and are fundamental for increasing knowledge for disease modification using precision medicine and for pharmacologic and non-pharmacologic intervention development in under-represented populations in AD clinical trials. The 4 related specific aims of the series are: 1. To understand how the current evidence examines specific genes, individually or in combination, are differentially distributed by ethnicity and sex, and are associated with higher risk or protection against LOAD between and among higher risk ethnic groups. 2. To describe how genetic risk may be modulated by factors such as epigenetics, age, sex, environmental exposures, lifestyle/diet, family and personal health histories, social, and demographic factors between and within ethnic groups and women at disproportionate risk for LOAD. 3. To examine current knowledge about how comorbidities such as vascular diseases, diabetes, and mental health moderate or mediate the increase risk of ADRD in these under-represented populations. 4. To explore underlying theory, new findings, and innovative observation, instrument development and calibration for respondent or patient assessment, and measurement/analytic strategies to improve our understanding of the gene x environment interactions influencing ADRD risk and how methods may be modified or adapted for use in specific research applications with higher risk minority populations and women.

佛罗里达国际大学 (FIU) 和埃默里大学的这份申请请求支持四年 系列研究会议旨在解决与减少阿尔茨海默病相关的关键科学问题 和相关痴呆症 (ADRD) 美国少数族裔之间的不平等。会议系列 我们建议依靠使用人口疾病框架的跨学科研究，特别关注 神经退行性疾病途径中的种族和性别差异。遗传和家庭/个人 健康史是不可改变的因素，可改变的因素包括广泛的生命周期环境 暴露和生活方式因素。该会议系列的重点是加深对遗传如何 因素与环境暴露、家庭和个人健康史以及生活方式共同作用 产生相互作用以增强或减轻种族群体内部和种族群体之间 ADRD 风险的因素， 特别是在非裔美国人、拉丁裔和非拉丁裔白人中。这些关键问题在很大程度上仍然存在 被忽视，但对于增加使用精准医学和疾病治疗的知识至关重要 针对 AD 代表性不足人群的药物和非药物干预开发 临床试验。该系列的 4 个相关具体目标是： 1. 了解当前证据如何检验 特定基因，单独或组合，因种族和性别而有差异分布，并且 与较高风险种族群体之间的较高风险或针对 LOAD 的保护有关。 2. 到 描述遗传风险如何受到表观遗传学、年龄、性别、环境暴露等因素的调节， 生活方式/饮食、家庭和个人健康史、种族之间和种族内部的社会和人口因素 LOAD 风险较高的群体和女性。 3. 检查目前关于合并症如何发生的知识 例如血管疾病、糖尿病和心理健康会减轻或介导这些人群中 ADRD 风险的增加 代表性不足的人群。 4. 探索基础理论、新发现和创新观察， 用于受访者或患者评估以及测量/分析的仪器开发和校准 提高我们对影响 ADRD 风险的基因 x 环境相互作用以及如何影响的理解的策略 可以修改或调整方法以用于具有较高风险少数群体的特定研究应用 人口和妇女。