Health Disparities in Alzheimers and Related Diseases

阿尔茨海默病和相关疾病的健康差异

基本信息

批准号：
10685967
负责人：
Jason R Richardson
金额：
$ 4.95万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-15 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10685967
关键词：
Address Affect African American population Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Area Attention Basic Science Brain Calibration Clinical Research Clinical Trials Communication Communities Dedications Demographic Factors Development Device or Instrument Development Diabetes Mellitus Diet Disease Education Enrollment Environmental Exposure Epidemiology Epigenetic Process Ethnic Origin Ethnic Population Family Florida Genes Genetic Genetic Risk Goals Health Health Disparities Research Hormonal Income Individual Inequity Interdisciplinary Study International Intervention Knowledge Late Onset Alzheimer Disease Latino Population Life Style Longevity Measurement Mediating Mental Health Metabolic Methods Minority Minority Groups Minority Women Modeling Modification Morbidity - disease rate Neurodegenerative Disorders Neurosciences Occupational Paper Pathology Pathway interactions Patients Peer Review Population Predisposition Process Public Health Publications Race Recording of previous events Reporting Research Respondent Rest Risk Science Scientist Series Sex Differences Theoretical model Therapeutic Intervention Time Toxicant exposure Training Translational Research Underrepresented Populations United States Universities Vascular Diseases Woman Work comorbidity dementia risk ethnic minority gene environment interaction health disparity high risk improved innovation instrument lifestyle factors lifetime risk model development pharmacologic precision medicine programs risk mitigation sex social social factors sociodemographic factors symposium theories therapy development

Address Affect African American population Age Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Area Attention Basic Science Brain Calibration Clinical Research Clinical Trials Communication Communities Dedications Demographic Factors Development Device or Instrument Development Diabetes Mellitus Diet Disease Education Enrollment Environmental Exposure Epidemiology Epigenetic Process Ethnic Origin Ethnic Population Family Florida Genes Genetic Genetic Risk Goals Health Health Disparities Research Hormonal Income Individual Inequity Interdisciplinary Study International Intervention Knowledge Late Onset Alzheimer Disease Latino Population Life Style Longevity Measurement Mediating Mental Health Metabolic Methods Minority Minority Groups Minority Women Modeling Modification Morbidity - disease rate Neurodegenerative Disorders Neurosciences Occupational Paper Pathology Pathway interactions Patients Peer Review Population Predisposition Process Public Health Publications Race Recording of previous events Reporting Research Respondent Rest Risk Science Scientist Series Sex Differences Theoretical model Therapeutic Intervention Time Toxicant exposure Training Translational Research Underrepresented Populations United States Universities Vascular Diseases Woman Work comorbidity dementia risk ethnic minority gene environment interaction health disparity high risk improved innovation instrument lifestyle factors lifetime risk model development pharmacologic precision medicine programs risk mitigation sex social social factors sociodemographic factors symposium theories therapy development

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项目摘要

This application from Florida International University (FIU) and Emory University requests support for a four-year research conference series to address critical scientific issues associated with reducing Alzheimer's Disease and Related Dementia (ADRD) inequities among ethnic minorities in the United States. The conference series we propose rests on interdisciplinary research using a population disease framework, with specific attention to ethnic groups and sex differences in pathways to neurodegenerative diseases. Genetics and family/personal health histories are non-modifiable factors, and modifiable factors include a wide range of lifespan environmental exposures and lifestyle factors. The conference series focuses on increasing understanding about how genetic factors are operating in concert with environmental exposures, family and personal health histories, and lifestyle factors to produce interactions that enhance or mitigate risk of ADRD within and between ethnic groups, specifically among African Americans, Latinos, and non-Latino Whites. These critical issues remain largely overlooked and are fundamental for increasing knowledge for disease modification using precision medicine and for pharmacologic and non-pharmacologic intervention development in under-represented populations in AD clinical trials. The 4 related specific aims of the series are: 1. To understand how the current evidence examines specific genes, individually or in combination, are differentially distributed by ethnicity and sex, and are associated with higher risk or protection against LOAD between and among higher risk ethnic groups. 2. To describe how genetic risk may be modulated by factors such as epigenetics, age, sex, environmental exposures, lifestyle/diet, family and personal health histories, social, and demographic factors between and within ethnic groups and women at disproportionate risk for LOAD. 3. To examine current knowledge about how comorbidities such as vascular diseases, diabetes, and mental health moderate or mediate the increase risk of ADRD in these under-represented populations. 4. To explore underlying theory, new findings, and innovative observation, instrument development and calibration for respondent or patient assessment, and measurement/analytic strategies to improve our understanding of the gene x environment interactions influencing ADRD risk and how methods may be modified or adapted for use in specific research applications with higher risk minority populations and women.

该申请来自佛罗里达国际大学（FIU）和埃默里大学（Emory University）的要求支持四年研究会议系列，以解决与减少阿尔茨海默氏病有关的关键科学问题和相关的痴呆症（ADRD）不平等现象。会议系列我们建议使用种群疾病框架的跨学科研究，并特别注意族裔群体和性别差异在神经退行性疾病的途径上。遗传学和家庭/个人健康历史是不可修改的因素，可修改的因素包括各种寿命环境暴露和生活方式因素。会议系列的重点是对遗传的了解不断增加因素与环境暴露，家庭和个人健康历史以及生活方式共同运行产生相互作用的因素，以增强或减轻种族内部和种族之间的ADRD风险，特别是在非裔美国人，拉丁美洲人和非拉丁裔白人中。这些关键问题仍在很大程度上仍然被忽视，是使用精确医学和用于AD中代表性不足的人群中的药理学和非药物干预发展临床试验。该系列的4个相关特定目的是：1。了解当前证据如何检查特定基因单独或结合在一起，是通过种族和性别差异分布的，并且是与较高风险或较高风险种族之间的负担相关。 2 描述如何通过表观遗传学，年龄，性别，环境暴露等因素调节遗传风险生活方式/饮食，家庭和个人健康历史，社会和人口统计学因素之间和种族因素群体和妇女承担负荷风险不成比例。 3。检查当前有关合并症的知识例如血管疾病，糖尿病和心理健康适度或调解ADRD的增加代表性不足的人群。 4。探索基本理论，新发现和创新观察，仪器的开发和校准，用于受访者或患者评估以及测量/分析提高我们对基因X环境相互作用的理解的策略影响ADRD风险以及如何方法可以修改或适用于具有较高风险少数风险的特定研究应用程序人口和妇女。