GLUCOCORTICOID RESPONSIVITY IN GULF WAR VETERANS

海湾战争退伍军人的糖皮质激素反应

• 批准号: 7718130
• 负责人: RACHEL YEHUDA
• 金额: $ 0.23万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718130
• 关键词: Brain; Computer Retrieval of Information on Scientific Projects Database; Feedback; Funding; Glucocorticoids; Grant; Gulf War; Health; Hippocampus (Brain); Hormones; Hydrocortisone; Institution; Laboratories; Link; Measures; Mediating; Memory; Memory impairment; Metabolism; Neurosecretory Systems; Outcome; Performance; Peripheral; Positron-Emission Tomography; Post-Traumatic Stress Disorders; Research; Research Personnel; Resources; Short-Term Memory; Source; Stress; Symptoms; Techniques; United States National Institutes of Health; Veterans; Work; base; design; glucose uptake; neuroimaging; neuropsychiatry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proposed research is designed to determine whether there is increased sensitvity to stress hormones (i.e., glucocorticoids) in the brains of Gulf War Veterans (GWVs), related to health symptoms, deployment stress, and health outcomes including Gulf War Illness (GWI) and/or posttraumatic stress disorder (PTSD). This will be assessed by examining the effect of hydrocortisone on both memory performance and glucose uptake in the brain as measured by Positron Emission Tomography (PET) neuroimaging techniques in GWV with and without PTSD and combat veterans who did not served in the Gulf War with and without PTSD. Based on our previous observations of enhanced cortisol negative feedback inhibition, which has been assessed using peripheral neuroendocrine technigues, we hypothesize that there will be greater sensitivity to hydrocortisone in GWVs and that this increase will be reflected in heightened working memory impairment and changes in hippocampal metabolism following hydrocortisone challenge. The observations of both low cortisol and enhanced negative cortisol inhibition have recently been extended to Gulf War veterans in our laboratory. The potential significance of the proposed work lies in 1) linking peripheral neuroendocrine alterations to brain function, 2) simultaneously examining the effects of cortisol on hippocampal metabolism and working memory performance and 3) identifying whether alterations in the brain function or peripheral neuroendocrine measures are related to PTSD and or health symptoms, including memory symptoms. This research is particularly warranted because memory impairments and neuropsychiatric symptoms are among the chief complaints in symptomatic GWVs. To the extent that these complaints are stress-related, this study will allow examination of the relationships among stress, memory and other symptoms and the neuroendocrine and brain changes that may mediate them. Hypothesis: Based on our previous observations of enhanced cortisol negative feedback inhibition, which has been assessed using peripheral neuroendocrine technigues, we hypothesize that there will be greater sensitivity to hydrocortisone in GWVs and that this increase will be reflected in heightened working memory impairment and changes in hippocampal metabolism following hydrocortisone challenge.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究旨在确定对墨西哥湾战争退伍军人（GWVS）大脑中应激激素（即糖皮质激素）的敏感性是否增加，与健康症状，部署压力以及包括海湾战争疾病（GWI）和/或或或或或/或或/或发生后压力障碍（PTSD）有关的健康症状，部署压力和健康状况有关。 这将通过检查氢化可的松对大脑记忆性能和葡萄糖吸收的影响，如通过有无PTSD的GWV中的正电子发射断层扫描（PET）神经成像技术所测量的，并且没有PTSD和战斗退伍军人，而在没有PTSD的Gulf War中没有服役的退伍军人。 基于我们以前对增强皮质醇负反馈抑制的观察，已经使用周围神经内分泌技术对此进行了评估，我们假设对GWV中的氢化可的松对氢化可的松的敏感性将更高，并且这种增加将在增强的工作记忆障碍和伴随Hydroportissalsiss攻击的增加的工作记忆障碍和变化中反映出来。 在我们的实验室中，对低皮质醇和增强的负皮质醇抑制作用的观察结果已扩展到海湾退伍军人。 提出的工作的潜在意义在于1）将周围神经内分泌的改变与脑功能联系起来，2）同时检查皮质醇对海马代谢和工作记忆性能的影响以及3）确定脑功能的改变还是与周围神经内分泌测量相关，包括与PTSD相关的症状以及健康症状，包括PTSD症状。 这项研究尤其有必要，因为记忆力障碍和神经精神症状是有症状的GWV的主要抱怨之一。 在某种程度上，这些投诉与压力有关，这项研究将允许检查压力，记忆和其他症状之间的关系以及可能介导它们的神经内分泌和大脑变化。 假设： 基于我们以前对增强皮质醇负反馈抑制的观察，已经使用周围神经内分泌技术对此进行了评估，我们假设对GWV中的氢化可的松对氢化可的松的敏感性将更高，并且这种增加将在增强的工作记忆障碍和伴随Hydroportissalsiss攻击的增加的工作记忆障碍和变化中反映出来。