AFFECTIVE INSTABILITY AND PROTEIN KINASE C SIGNAL TRANSDUCTION PATHWAYS

情感不稳定性和蛋白激酶 C 信号转导途径

• 批准号: 7718110
• 负责人: Harold W Koenigsberg
• 金额: $ 0.74万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718110
• 关键词: Affective; Blood Platelets; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Patients; Personality Disorders; Protein Kinase; Protein Kinase C; Research; Research Personnel; Resources; Signal Transduction Pathway; Source; United States National Institutes of Health; trait; valproate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of the proposed study is to determine whether the trait of affective instability (A1) in patients with personality disorders is associated with levels of platelet protein kinase C (PKC) activity which differ from that seen in healthy controls and in personality disorder patients without effective instability. The secondary objective is to determine whether treatment of personality disorder patients who have affective instability with valproate or olanzepine will normalize PKC activity and whether the degree of this normalization correlates with symptomatic improvement.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议研究的主要目的是确定人格障碍患者情感不稳定性（A1）的特征是否与血小板蛋白激酶C（PKC）活性水平有关，这与在健康对照组和没有有效不稳定性的人格障碍患者中所见。 次要目标是确定治疗具有丙戊酸或奥氮平不稳定性的人格障碍患者是否会使PKC活性正常化，以及这种归一化的程度是否与症状改善相关。