AFFECTIVE INSTABILITY AND PROTEIN KINASE C SIGNAL TRANSDUCTION PATHWAYS

情感不稳定性和蛋白激酶 C 信号转导途径

• 批准号: 7718110
• 负责人: Harold W Koenigsberg
• 金额: $ 0.74万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718110
• 关键词: Affective; Blood Platelets; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Patients; Personality Disorders; Protein Kinase; Protein Kinase C; Research; Research Personnel; Resources; Signal Transduction Pathway; Source; United States National Institutes of Health; trait; valproate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of the proposed study is to determine whether the trait of affective instability (A1) in patients with personality disorders is associated with levels of platelet protein kinase C (PKC) activity which differ from that seen in healthy controls and in personality disorder patients without effective instability. The secondary objective is to determine whether treatment of personality disorder patients who have affective instability with valproate or olanzepine will normalize PKC activity and whether the degree of this normalization correlates with symptomatic improvement.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议研究的主要目的是确定人格障碍患者的情感不稳定 (A1) 特征是否与血小板蛋白激酶 C (PKC) 活性水平相关，而血小板蛋白激酶 C (PKC) 活性水平与健康对照和人格障碍患者中的​​不同。没有有效的不稳定。 第二个目标是确定用丙戊酸或奥氮平治疗情感不稳定的人格障碍患者是否会使 PKC 活性正常化，以及这种正常化的程度是否与症状改善相关。