FMRI OF WORKING MEMORY IN THE SCHIZOPHRENIA SPECTRUM

精神分裂症谱系中工作记忆的 FMRI

• 批准号: 7953679
• 负责人: Harold W Koenigsberg
• 金额: $ 0.15万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953679
• 关键词: Antipsychotic Agents; Area; Brain; Brain region; Cerebrovascular Circulation; Cerebrum; Chronic; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Functional Magnetic Resonance Imaging; Funding; Genetic; Grant; Impaired cognition; Institution; Legal patent; Measures; Metabolic; Morphologic artifacts; Pathology; Patients; Pharmaceutical Preparations; Population; Recruitment Activity; Research; Research Personnel; Resources; Schizophrenia; Schizotypal Personality Disorder; Short-Term Memory; Source; Symptoms; United States National Institutes of Health; Visuospatial; frontal lobe; functional disability; neurobiological mechanism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the proposed study is to visualize which regions of the brain show different metabolic activity in schizotypal patients and schizophrenic patients compared to normal controls while they are engaged in a carefully defined visual-spatial working memory task. This will help us to better understand the neurobiological mechanisms of cognitive impairment in schizophrenia. Schizotypal patients are a particularly informative group to study to understand the cognitive impairments in schizophrenia since they share genetic and phenomenological features with schizophrenia, yet do not have concurrent psychotic symptoms which might confound interpretation of the regional brain metabolic activity associated with cognitive impairment. SPD patients also typically provide a population that has not been exposed to neuroleptic medications, the chronic effects of which, could introduce an artifact in studies of brain activity. The proposed study will use fMRI to record regional cerebral blood flow (rCBF), a measure of cerebral metabolic activity, in 24 SPD patients 24 schizophrenic patients and 48 normal controls as they carry out a visual-spatial working memory task. Hypothesis: We expect that schizophrenia spectrum patients (SPD and SCZ patents) will have a functional impairment in BA 9/46 and will activate this region less strongly than healthy controls in carrying out a visuospatial working memory task. To compensate, they will recruit other cortical areas, including BA 10, in particular. However, SCZ patients may not be able to activate BA 10 as effectively as SPD patients, likely because of a greater degree of pathology in the frontal lobe.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究的目的是可视化哪些大脑区域在精神错型患者和精神分裂症患者中与正常对照组相比，在仔细定义的视觉空间工作记忆任务时，在精神错型患者和精神分裂症患者中表现出不同的代谢活性。这将有助于我们更好地了解精神分裂症认知障碍的神经生物学机制。精神分裂型患者是一个特别有用的研究组，可以研究精神分裂症的认知障碍，因为他们与精神分裂症具有遗传和现象学特征，但没有并发的精神病症状，这些症状可能会混淆与认知障碍相关的区域脑代谢活性的解释。 SPD患者通常还提供尚未暴露于神经蛋白质药物的人群，其慢性作用可能会引入大脑活动研究中的伪像。 拟议的研究将使用fMRI记录区域脑血流量（RCBF），这是一项衡量大脑代谢活性的量度，在24名SPD患者中，有24名精神分裂症患者和48例正常对照对照，他们执行视觉空间工作记忆任务。 假设：我们预计精神分裂症谱系患者（SPD和SCZ专利）将在BA 9/46中具有功能障碍，并且在执行视觉空间工作记忆任务时，该区域的激活比健康对照较少。为了补偿，他们将特别招募包括BA 10在内的其他皮质区域。但是，SCZ患者可能无法像SPD患者那样有效地激活BA 10，这可能是由于额叶的病理程度更高。