SOYBEAN DIET AND BREAST DENSITY

大豆饮食和乳房密度

• 批准号: 7719169
• 负责人: LEE-JANE W LU
• 金额: $ 17.62万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719169
• 关键词: Adverse effects; Asians; Cattle; Chronic; Computer Retrieval of Information on Scientific Projects Database; Consumption; Country; Daily; Detection; Development; Diet; Dietary Intervention; Double-Blind Method; Estradiol; Estrone-Sulfate; Funding; Glycine max; Grant; Institution; Isoflavones; Mammary Gland Parenchyma; Mammographic Density; Mammography; Measures; Milk; Ovarian Steroid Hormone; Ovarian hormone; Placebos; Population; Premenopause; Preventive; Progesterone; Randomized; Rate; Research; Research Personnel; Resources; Screening procedure; Source; Soybeans; Testing; Tissues; United States National Institutes of Health; Upper arm; Woman; Women' s Group; breast density; cancer risk; comparative; dietary supplements; feeding; improved; malignant breast neoplasm; soy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Populations consuming high levels of soy, as in many Asian countries, have lower levels of ovarian hormones, lower rates of breast cancer, and reduced mammographic density than populations consuming typical Western diets. We found that soy feeding favorably lowered ovarian hormones by 25-45% in premenopausal women. We propose to test the typothesis that consumption of soya reduces ovarian steroid hormones (estradiol, estrone, sulfate, and progesterone) and results in a corresponding reduction in breast density and that these effects can be achieved with a soy diet that does not contain isoflavones. Aim 1 determines the assess potential adverse effects of chronic soy exposure. The aims will be tested by conducting a randomized, double-blind study, with two arms and 100 premenopausal women in each arm. Premenopausal women with 50% of dense breast tissue will randomly allocated to take soymilk without isoflavones (treatment) or cow milk (placebo) as dietary supplements daily for 2 years. The comparative levels of ovarian steroids, hormones and breast density will be assessed before, during and after 2 years of dietary interventions in these two groups of women. Reducing breast density can be expected to reduce breast cancer risk by two mechanisms, i.e., reducing the volume of target tissue at risk for cancer development and improving the sensitivity of mammography for early screening detection. One of our long-term objectives is to determine if soy can be an alternative and complementary preventive measure for a second breast cancer.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 与食用典型西方饮食的人群相比，食用大量大豆的人群（如许多亚洲国家）的卵巢激素水平较低，乳腺癌发病率较低，乳房X线照相密度也较低。 我们发现，食用大豆可以使绝经前女性的卵巢激素降低 25-45%。 我们建议测试以下假设：食用大豆会减少卵巢类固醇激素（雌二醇、雌酮、硫酸盐和黄体酮），并导致乳房密度相应降低，而这些效果可以通过不含异黄酮的大豆饮食来实现。 目标 1 确定评估长期接触大豆的潜在不利影响。 这些目标将通过一项随机、双盲研究进行测试，该研究有两组，每组 100 名绝经前妇女。 具有 50% 致密乳腺组织的绝经前妇女将被随机分配每天服用不含异黄酮的豆奶（治疗）或牛奶（安慰剂）作为膳食补充剂，持续 2 年。 将在这两组女性进行饮食干预之前、期间和之后 2 年评估卵巢类固醇、激素和乳房密度的比较水平。降低乳腺密度有望通过两种机制降低乳腺癌风险，即减少有癌症发展风险的目标组织的体积和提高乳房X线照相术用于早期筛查检测的灵敏度。 我们的长期目标之一是确定大豆是否可以成为第二种乳腺癌的替代和补充预防措施。