SOYBEAN DIET AND BREAST DENSITY

大豆饮食和乳房密度

• 批准号: 7378702
• 负责人: LEE-JANE W LU
• 金额: $ 25.68万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378702
• 关键词: SOYBEAN; DIET; BREAST; DENSITY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Populations consuming high levels of soy, as in many Asian countries, have lower levels of ovarian hormones, lower rates of breast cancer, and reduced mammographic density than populations consuming typical Western diets. We found that soy feeding favorably lowered ovarian hormones by 25-45% in premenopausal women. We propose to test the hypothesis that consumption of soya reduces ovarian steroid hormones (estradiol, estrone, sulfate, and progesterone) and results in a corresponding reduction in breast density and that these effects can be achieved with a soy diet that does not contain isoflavones. Aim 1 determines the effects of a diet supplemented with isoflavone-free soy on ovarian hormone levels and breast density. Aim 2 assesses the safety of this intervention. The aims will be tested by conducting a randomized, double-blind study, with two arms and 100 premenopausal women in each arm. Premenopausal women with 50% of dense breast tissue will be randomly allocated to take soymilk without isoflavones (treatment) or cow milk (placebo) as dietary supplements daily for 2 years. The comparative levels of ovarian steroids, hormones and breast density will be assessed before, during and after 2 years of dietary interventions in both groups. Reducing breast density can be expected to reduce breast cancer risk by two mechanisms, i.e., reducing the volume of target tissue at risk for cancer development and improving the sensitivity of mammography for early screening detection. A long-term objective is to determine if soy can be an alternative and complementary preventive measure for a second breast cancer.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。与典型的西方饮食相比，与许多食用典型西方饮食的种群相比，卵巢荷尔蒙的水平较低，乳腺癌率较低，乳腺癌的率降低，乳腺癌的率降低，乳腺癌的率降低，乳腺癌的率较低，较低的大豆的种群比食用典型的西方饮食。我们发现，大豆在绝经前女性中喂养有利的卵巢激素25-45％。我们建议检验以下假设：大豆的消耗降低了卵巢类固醇激素（雌二醇，雌二醇，硫酸盐和孕酮），并导致乳房密度相应地降低，并且可以通过不含异黄酮的大豆饮食来实现这些作用。 AIM 1确定补充了无异黄酮大豆对卵巢激素水平和乳房密度的影响。 AIM 2评估了此干预的安全性。该目标将通过进行随机的双盲研究来测试，每个手臂中有两个臂和100个月疗线前女性。具有50％密集乳腺组织的月球前女性将随机分配以服用无异黄酮（治疗）或牛奶（安慰剂），每天用作饮食补充2年。两组饮食两年的饮食干预措施之前，期间和之后，将评估卵巢类固醇，激素和乳房密度的比较水平。可以预期，可以通过两种机制降低乳腺癌的风险，即减少有癌症发育风险的目标组织的体积，并提高乳腺X线摄影的敏感性以提早筛查。一个长期目标是确定大豆是否可以成为第二种乳腺癌的替代和补充预防措施。