800 MHz NMR console replacement

800 MHz NMR 控制台更换

• 批准号: 7796258
• 负责人: MARK A RANCE
• 金额: $ 35.83万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-10 至 2010-12-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7796258
• 关键词: 14 year old; Area; Arts; Biological Process; Cardiovascular system; Cystic Fibrosis; Equipment; Funding; Generations; Housing; Inflammatory; Kidney Diseases; Medicine; Microbial Biofilms; Performance; Process; Request for Proposals; Research; Research Personnel; Research Project Grants; Signal Transduction; Structural Biologist; Universities; college; improved; instrument; instrumentation; molecular recognition; structural biology

DESCRIPTION (provided by applicant): In order for structural biologists to continue to tackle increasingly difficult problems, it is vital to exploit whatever technological advances are available. The current proposal requests funds to purchase a state-of-the-art console for the 800 MHz NMR spectrometer that is housed in the structural biology/NMR facility within the University of Cincinnati College of Medicine. The requested equipment will replace a 14 year old, prior generation console, and will significantly enhance the performance of a wide range of NIH-funded research projects. Investigators using the 800 NMR instrument are currently pursuing health-related studies in areas such as cardiovascular research, biofilm formation, cystic fibrosis, kidney disease and inflammatory processes. Other projects are focused on understanding fundamental biological processes such as cellular signaling mechanisms and molecular recognition. All of these applications will benefit significantly from the improved sensitivity, reliability and spectral fidelity achievable with the latest generation of NMR instrumentation. The new console will also allow optimal results to be obtained with the cryogenically cooled probe that is currently installed in the 800 MHz magnet.

描述（由申请人提供）：为了使结构生物学家继续解决日益困难的问题，利用任何可用的技术进步至关重要。当前的提案要求资金为800 MHz NMR光谱仪购买最先进的控制台，该控制仪位于辛辛那提大学医学院的结构生物学/NMR设施中。要求的设备将取代14岁的上一代控制台，并会大大提高广泛的NIH资助研究项目的性能。使用800 NMR仪器的研究人员目前正在在心血管研究，生物膜形成，囊性纤维化，肾脏疾病和炎症过程等领域进行与健康有关的研究。其他项目的重点是理解基本生物学过程，例如细胞信号传导机制和分子识别。所有这些应用都将从最新一代的NMR仪器中可以实现的提高灵敏度，可靠性和光谱保真度中受益匪浅。新的控制台还将允许使用当前安装在800 MHz磁铁中的低温冷却探针获得最佳结果。