3.0T Whole-Body Cardiovascular MRI System

3.0T全身心血管核磁共振系统

• 批准号: 7842714
• 负责人: Debiao Li
• 金额: $ 252.24万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7842714
• 关键词: Cardiovascular Diseases; Cardiovascular system; Carotid Artery Diseases; Coronary Arteriosclerosis; Detection; Diagnostic; Diagnostic Imaging; Disease; Disease Progression; Elements; Environmental Impact; Equipment; Funding; Goals; Image; Institution; Islets of Langerhans Transplantation; Leadership; Length; Magnetic Resonance Imaging; Neurologic; Noise; Organ; Pain; Patients; Peripheral arterial disease; Positioning Attribute; Public Health; Pulmonary artery structure; RF coil; Research Personnel; Resolution; Scanning; Scientist; Signal Transduction; Speed; System; Technology; Time; Universities; body system; experience; improved; instrument; medical schools; nervous system disorder; public health relevance; public health research; tool

DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is to improve he detection and treatment for patients suffering from various diseases in the neurological, cardiovascular, or body systems. Investigators at the Northwestern University Feinberg School of Medicine propose to purchase a 3.0T whole-body magnetic resonance imaging system for noninvasive detection of various diseases. The diseases to be studied in this proposal represent major public health problems and the requested 3.0T scanner will provide high resolution imaging of organs involved in target diseases. This imaging will help quantify disease progression in coronary artery disease, peripheral artery disease, carotid artery disease, pulmonary artery disease, and neurological disease. The availability of a new 3.0T MRI system will support current NIH-funded projects to understand the mechanisms of these diseases. The requested new system will provide improved signal to noise ratio, resulting in shorter scan times and improved spatial resolution, compared to 1.5 MRI already present at this institution. In addition, the new 3.0T system has wider bore and shorter length of the magnet than current 3.0T systems, which will help open the doors to high-quality diagnostic imaging for patients who typically have not had access to MR imaging, particularly those who are claustrophobic, in pain or discomfort. With RF coil integration technology, up to 102 simultaneously connected coil elements can be seamlessly integrated onto one examination, allowing 3D high-speed, high-resolution parallel imaging. Major users of the requested instrument will include highly accomplished scientists who specialize in neurological diseases, cardiovascular disease, and islet cell transplantation. Extensive technical experience exists in our institution. A comprehensive technical, scientific, administrative, and financial plan is proposed to govern usage of this instrument at our institution. This application had strong support from the institutional leadership. The relevance to public health of research performed on this requested equipment is to develop more accurate diagnostic tools for neurological, body, and cardiovascular diseases. The long-term goal is to improve patient treatments and evaluate potential therapies. PUBLIC HEALTH RELEVANCE: The relevance to public health of research performed on this requested equipment is to develop more accurate diagnostic tools for neurological, body, and cardiovascular diseases. The long-term goal is to improve patient treatments and evaluate potential therapies. Two new positions will be created to operate and maintain the requested 3.0T imaging system. There is no direct and apparent environmental impact of the instrument.

描述（由申请人提供）：该提案的广泛，长期目标是改善他的检测和治疗，以针对神经，心血管或身体系统中各种疾病的患者进行检测和治疗。西北大学Feinberg医学院的调查人员建议购买3.0吨的全身磁共振成像系统，用于无创的各种疾病。该提案中要研究的疾病代表了重大的公共卫生问题，所要求的3.0T扫描仪将对涉及目标疾病的器官提供高分辨率成像。该成像将有助于量化冠状动脉疾病，周围动脉疾病，颈动脉疾病，肺动脉疾病和神经疾病的疾病进展。新的3.0T MRI系统的可用性将支持当前由NIH资助的项目了解这些疾病的机制。要求的新系统将提供改善的信号与噪声比，从而导致扫描时间较短并改善了空间分辨率，而该机构已经存在1.5 MRI。此外，新的3.0T系统比当前的3.0T系统具有更大的孔隙和较短的磁铁长度，这将有助于为通常无法使用MR成像的患者打开高质量诊断成像的门，尤其是那些疼痛或不适的幽闭恐惧症的患者。使用RF线圈集成技术，可以将多达102个连接的线圈元件无缝集成到一个检查中，从而允许3D高速，高分辨率并行成像。所要求的仪器的主要用户将包括专门研究神经系统疾病，心血管疾病和胰岛细胞移植的高度成就的科学家。我们机构中存在丰富的技术经验。提出了一项全面的技术，科学，行政和财务计划，以管理我们机构对该工具的使用。该申请得到了机构领导的大力支持。与该要求的设备进行的研究的相关性是为神经，身体和心血管疾病开发更准确的诊断工具。长期目标是改善患者治疗并评估潜在的疗法。 公共卫生相关性：与此要求的设备进行的研究的相关性是为神经，身体和心血管疾病开发更准确的诊断工具。长期目标是改善患者治疗并评估潜在的疗法。将创建两个新的位置，以操作和维护所需的3.0T成像系统。该工具没有直接和明显的环境影响。