Uranium exposure in drinking water and cardiovascular disease in the Strong Heart Study

强心研究中饮用水中的铀暴露与心血管疾病

• 批准号: 10679514
• 负责人: Wil Forrest Lieberman-Cribbin
• 金额: $ 3.47万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10679514
• 关键词: Affect; American Indians; Arizona; Cardiovascular Diseases; Cardiovascular system; Carotid Artery Plaques; Characteristics; Chronic; Clinical; Cohort Studies; Communities; Data; Data Set; Databases; Death Records; Disease; Disease Outcome; Dose; Echocardiography; Elements; Environment; Environmental Wind; Evaluation; Family Study; General Population; Health; Heart; Hospitalization; Household; Hypertension; Image; Incidence; Information Systems; Intervention; Kidney; Left; Link; Location; Longitudinal cohort; Machine Learning; Measurement; Measures; Metal exposure; Metals; Mining; Modeling; North Dakota; Oklahoma; Outcome; Participant; Peripheral arterial disease; Pilot Projects; Population; Population Heterogeneity; Prevalence; Privatization; Probability; Prospective Studies; Regulation; Research; Resources; Risk; Risk Factors; Sampling; Site; Soil; Source; South Dakota; Stream; System; Time; Tobacco smoking behavior; Toxic effect; United States; Uranium; Urine; Ventricular; Water; Work; anthropogenesis; burden of illness; cardiovascular disorder risk; cardiovascular health; data resource; drinking water; follow-up; geochemistry; ground water; insight; policy recommendation; primary outcome; secondary outcome; urinary

PROJECT SUMMARY Uranium (U) is a naturally occurring element potentially associated with cardiovascular health outcomes. Across the United States (US), U is released into the environment through wind and water erosion, as well as anthropogenic mining, milling and other forms of U processing. Importantly, U is ubiquitous in American Indian (AI) communities, where the cardiovascular disease (CVD) burden remains disproportionally high, and U exposure via drinking water remains a concern. While the maximum contaminant level (MCL) for U in public water systems (30 µg/L) took effect in 2008, no MCL was regulated in the US prior to this time, and AI communities relying on private wells for drinking water are not regulated. The Strong Heart Study (SHS), a prospective study of CVD among AI communities in North Dakota, South Dakota, Arizona and Oklahoma, represents an important population to understand the extent and impact of U exposure on health outcomes. This requires a comprehensive assessment of both water and internal dose U exposure, including U measured in urine. However, urinary U data is only available in a kinship-based extension of the SHS, those comprising the Strong Heart Family Study (SHFS), and there is need to estimate this exposure across the entire SHS community to identify those with elevated U exposure and determine the long-term health outcomes. The objectives of this study are to 1) estimate water U exposure in SHS and SHFS participants relying on existing nationwide groundwater measurements, 2) estimate urinary U concentrations in SHS participants leveraging the associations between drinking water U and urinary U concentrations in the SHFS, and 3) investigate if estimated U exposure (water and urinary) in the SHS and SHFS is linked to CVD outcomes, both overall, and according to participant region and other characteristics. Water U exposure estimations (Aim 1) will rely on community water system estimations of U concentrations derived from the US EPA, the National Uranium Resource Evaluation Hydrogeochemical and Stream Sediment Reconnaissance database, which includes 335,547 sampling locations across the contiguous US collected from 1975 to 1980; the USGS National Water Information System, which provides water-resources data on over 1.9 million sites across the US; the Strong Heart Water Study, a pilot study of household water U measures (n = 441); and the USGS Reconnaissance study. These datasets will be used to assign water U measures to household locations. For Aim 2, the relationship between estimated water U exposure and urinary U concentrations in SHFS will be used to predict urinary U values in SHS participants with machine learning approaches. For Aim 3, we will investigate the association between estimated water and urinary U concentrations with both clinical and subclinical cardiovascular outcomes in SHS and SHFS participants. This work will estimate U exposure across the entire SHS, identify populations at increased risk of U-related CVD outcomes, and inform interventions to reduce water U exposure in AI communities and other communities equally affected by U exposure across the US.

项目摘要 铀（U）是一种可能与心血管健康结果相关的天然元素。穿过 美国（美国），U通过风和水侵蚀将其释放到环境中， 人为开采，铣削和其他形式的U加工。重要的是，U在美洲印第安人中无处不在 （AI）社区，心血管疾病（CVD）烧伤的社区保持不成比例，U 通过饮用水暴露仍然是一个问题。而在公共场合使用的最大污染物水平（MCL） 水系统（30 µg/L）在2008年生效，此时在美国没有监管MCL，AI 依靠私人井的饮用水社区不受监管。强大的心脏研究（SHS）， 北达科他州，南达科他州，亚利桑那州和俄克拉荷马州的AI社区中CVD的前瞻性研究 代表着一个重要的人群，以了解U暴露对健康结果的程度和影响。这 需要对水和内部剂量U的全面评估，包括在 尿。但是，尿液数据仅在基于亲属关系的SHS扩展中可用， 强大的心脏家庭研究（SHFS），需要估计整个SHS社区的这种曝光率 确定升高U暴露的人并确定长期健康结果。目标的目标 研究是1）估计SHS和SHFS参与者中依靠现有的全国范围的水暴露 地下水测量，2）估计SHS参与者的尿液含量 饮用水U与SHF中尿液浓度之间的关联，3）研究是否估计 SHS和SHF中的U暴露（水和尿液）与CVD结果有关，无论是总体而言， 参与者区域和其他特征。水U暴露估算（AIM 1）将依靠社区水 美国EPA的U浓度的系统估计，国家铀资源评估 水力地球化学和溪流沉积物侦察数据库，其中包括335,547个采样位置 从1975年至1980年收集的整个连续美国； USGS国家水信息系统，该系统 提供有关美国超过190万个地点的水资源数据；强大的心脏水研究，飞行员 研究家用水的研究（n = 441）；以及USGS侦察研究。这些数据集将是 用于将水措施分配给家庭位置。对于AIM 2，估计的水之间的关系 SHF中的U暴露和尿液浓度将用于预测SHS参与者的尿值U值 使用机器学习方法。对于AIM 3，我们将调查估计的水与 SHS和SHF中的临床和亚临床心血管结局的尿液浓度均具有 参与者。这项工作将估算整个SHS的暴露，确定人口的风险增加 与U相关的CVD结果，并告知干预措施以减少AI社区和其他其他 在整个美国受U暴露的社区同样受到影响。