Cancer Genomics Shared Resource

癌症基因组学共享资源

基本信息

批准号：
10092987
负责人：
Lance David Miller
金额：
$ 12.59万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-02-01 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10092987
关键词：
Achievement Advisory Committees Applications Grants Area Award Awareness Baptist Church Bioinformatics Bioinformatics Shared Resource Biometry Cancer Center Support Grant Clinical Collaborations Competence Comprehensive Cancer Center Critiques Data Dependence Development Disease Doctor of Philosophy Education Environment Etiology Fostering Genetic Genomic medicine Genomics Genomics Shared Resource Goals Grant Institution Interdisciplinary Study Joints Laboratories Malignant Neoplasms Microarray Analysis Microarray Shared Resource Mission Molecular Outcome Output Precision Medicine Initiative Process Productivity Publications Recommendation Records Research Research Personnel Resource Sharing Resources Role Services Strategic Planning Technology Translating Vision cancer genomics cost effective experience forest medical schools member next generation sequencing operation personalized medicine precision oncology translational cancer research translational genomics

项目摘要

CANCER GENOMICS SHARED RESOURCE Project Summary Next-generation sequencing (NGS) and microarray technologies are essential resources for investigating the genomic and molecular underpinnings of cancer formation, progression, and clinical outcomes. The primary objective of the Cancer Genomics Shared Resource (CGSR) is to maximize the scientific and clinical impact of research by Wake Forest Baptist Comprehensive Cancer Center (WFBCCC) members. This is accomplished by providing rapid and cost-effective access to state-of-the-art genomic technologies, while creating a unifying environment that cultivates scientific awareness, education, and collaboration. The CGSR supports the WFBCCC's mission by providing cancer-prioritized access to comprehensive microarray and NGS technologies and offers seamless data flow through to the Biostatistics and Bioinformatics Shared Resource - for bioinformatics support. In October 2014, at the instigation of Director Pasche, the former Microarray Core Laboratory (2002-2014; which received a score of “excellent” in the prior critique) was renamed the Cancer Genomics Shared Resource to reflect the integration of the WFBCCC's microarray core competencies with the NGS expertise of the Center for Genomics and Personalized Medicine Research. This new joint-Center partnership reflects the strategic plans of the WFBCCC and the Wake Forest School of Medicine (WFSOM), as well as supporting priority recommendations of the WFSOM Centers and Cores Advisory Committee. The CGSR provides cutting-edge genomic services, prioritizes cancer-specific research, creates an optimal environment for the Institution's rapidly developing precision medicine initiative, and seamlessly integrates with other key Shared Resources within the WFBCCC to promote integrated, high-quality workflows for cancer genomics research. The CGSR is led by Co-Directors Lance Miller, Ph.D., and Greg Hawkins, Ph.D., who have established records in cancer genomics research, and is operated by four experienced technicians (two at 100% effort, one at 50% effort and one at 5% effort). A bioinformatician devotes 30% of effort to CGSR daily operations. In the most recent grant year (11/01/14-10/31/15), the CGSR operated at 80-90% FTE utilization to provide 1,144 services to 20 investigators, 75% of which were WFBCCC investigators. Compared to previous years, the CGSR doubled its service output and increased its cancer-specific service output by approximately 50%. The CGSR directly contributes to the scientific achievements of WFBCCC investigators by generating high-quality and cost-effective data that will translate into new discoveries, publications, grant awards, and grant applications. Further development of CGSR's role in supporting the development and productivity of WFBCCC Disease-Oriented Teams and the continued development of seamless workflows across Shared Resources are expected to enhance translational genomics initiatives at the WFBCCC.

癌症基因组学共享资源项目概要新一代测序 (NGS) 和微阵列技术是研究该疾病的重要资源癌症形成、进展和临床结果的基因组和分子基础。癌症基因组学共享资源 (CGSR) 的目标是最大限度地发挥癌症基因组学共享资源的科学和临床影响维克森林浸信会综合癌症中心 (WFBCCC) 成员的研究已完成。通过提供快速且经济高效的最先进的基因组技术，同时创建一个统一的 CGSR 支持培养科学意识、教育和协作的环境。 WFBCCC 的使命是提供癌症优先的综合微阵列和 NGS 获取途径技术并提供无缝数据流到生物统计和生物信息学共享资源 - 2014 年 10 月，在前 Microarray 核心主任 Pasche 的怂恿下。实验室（2002-2014；在之前的评审中获得“优秀”分数）更名为癌症实验室基因组学共享资源反映了 WFBCCC 的微阵列核心能力与基因组学和个性化医学研究中心的 NGS 专业知识这个新的联合中心。该伙伴关系反映了 WFBCCC 和维克森林医学院 (WFSOM) 的战略计划，以及支持 WFSOM 中心和核心咨询委员会的优先建议。 CGSR 提供尖端的基因组服务，优先考虑癌症特异性研究，创建最佳的为该机构快速发展的精准医学计划提供环境，并与 WFBCCC 内的其他关键共享资源，以促进癌症的集成、高质量工作流程 CGSR 由联合主任 Lance Miller 博士和 Greg Hawkins 博士领导。在癌症基因组学研究方面建立了记录，由四名经验丰富的技术人员（两名一位生物信息学家每天将 30% 的精力投入到 CGSR 上。在最近的拨款年度（2014 年 11 月 1 日至 2015 年 10 月 31 日），CGSR 的 FTE 利用率为 80-90%，与之前相比，为 20 名调查员提供了 1,144 项服务，其中 75% 是 WFBCCC 调查员。多年来，CGSR 的服务产出翻了一番，并将癌症特定服务产出增加了约 50% CGSR 通过生成直接为 WFBCCC 研究者的科学成就做出贡献。高质量且具有成本效益的数据将转化为新的发现、出版物、资助奖项和进一步发展 CGSR 在支持发展和生产力方面的作用。 WFBCCC 以疾病为导向的团队以及跨共享的无缝工作流程的持续开发预计资源将增强 WFBCCC 的转化基因组学计划。