Admin: Mechanical determinants of organ-selective metastatic colonization, dormancy and outgrowth

管理员：器官选择性转移定植、休眠和生长的机械决定因素

• 批准号: 10490282
• 负责人: ROGER D KAMM
• 金额: $ 40.7万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10490282
• 关键词: Achievement; Address; Administrator; Advisory Committees; Advocate; Agreement; Applications Grants; Award; Biochemical; Blood Circulation; Breast Cancer Patient; Cells; Cessation of life; Chromatin; Chromatin Structure; Clinical; Collaborations; Communication; Communities; Computer Models; Dana-Farber Cancer Institute; Data; Data Commons; Data Set; Development; Disease; Disease Progression; Disseminated Malignant Neoplasm; Ensure; Environment; Evaluation Research; Exposure to; Fostering; Gene Expression Profile; Grant; In Vitro; Institution; Intervention; Knowledge; Lead; Leadership; Malignant Neoplasms; Mechanics; Mission; Modeling; Molecular; Monitor; Neoplasm Circulating Cells; Neoplasm Metastasis; Organ; Pathology; Patients; Pennsylvania; Phenotype; Pilot Projects; Program Reviews; Proliferating; Protocols documentation; Publications; Quality Control; Records; Reporting; Reproducibility; Research; Research Personnel; Research Project Grants; Resource Sharing; Schedule; Scientist; Series; Signal Transduction; Site Visit; Source; Stress; Stromal Cells; Structure; Technology; Texas; Time; TimeLine; Tissues; Universities; Validation; Videoconferencing; Visit; anticancer research; data quality; data sharing; high resolution imaging; in silico; in vivo; meetings; member; metadata standards; multidisciplinary; neoplastic cell; programs; repository; research data dissemination; response; skill acquisition; stressor; symposium; transcriptome; transcriptomics; tumor microenvironment; virtual; web site; webinar; working group

Administrative Core: SUMMARY We propose to bring together an unparalleled team comprised of five leaders in metastatic cancer research across five institutions (MIT, University of Pennsylvania, Northwestern University, MD Anderson at The University of Texas, and the Dana Farber Cancer Institute at Harvard University). The proposed MetNet Center Administrative Core will be led by co-MPI Prof. Roger Kamm. The day-to-day administration of this grant will be managed by the Center Administrator, located at MIT, who will be responsible for maintaining all records relative to this award and will establish and monitor agreements with affiliated institutions. Additionally, center administration will be supported by a Data Manager, who will be located at Harvard under the co-direction of Dr. Franziska Michor. The Data Manager will sit on the Resource and Data Sharing Working Group of MetNet and will be responsible for the co-development (in collaboration with the Center Administrator) of the MetNet Center’s website, discussions regarding standard metadata fields, determine whether there will be pre-publication of data sharing across the MetNet, create SOPs for MetNet data upload in conjunction with the different NCI Cancer Research Data Commons, and lead the conversations about data quality control, cross validation, and reproducibility. An External Advisory Committee (EAC) will be formed, bringing together investigators with expertise in fields related to cancer metastasis and the tumor microenvironment. The EAC is envisioned as a group of highly active members engaged to advise the MetNet Center leadership on scientific direction and review progress evaluation, research strategies and implementation, leadership and dissemination, all in the effort to maximize the impact of the center. The MetNet center will enhance the translational value and potential impact of its research by engaging a Patient Advocate, who will be a member of the EAC as a reviewer and evaluator of the pilot project grant applications, and will be invited to attend the monthly research webinars and participate in the quarterly Co-MPI meetings, and the Annual Site Visit. To foster collaboration and further support multi-institutional communication, wide reaching knowledge dissemination, and provide the MetNet Center trainees opportunities for enhancing their technical and professional development skills, the Administrative Core will support a virtual, monthly seminar series, and will offer intra-MetNet Center research exchanges and $50,000 pilot projects. In Aim 1 the Administrative Core will oversee and coordinate the project mission, establish multidisciplinary project oversight and establish timeline milestones with videoconferencing and face-to-face meetings. In Aim 2, we will develop, coordinate, schedule, and evaluate research meetings, research symposia, and the visiting scientists’ programs that are critical to our research mission and dissemination. In Aim 3, we will create the MetNet Center’s website to: facilitate communication on program achievements; act as the access point for enquiries from external researchers; serve as publicly-facing source of accessible research results to inform the breast cancer patient community; and serve as a central and accessible repository for all Center generated protocols.

行政核心：摘要 我们建议将一个无与伦比的团队汇集在一起​​，完成了五个转移性癌症领导者 五个机构的研究（麻省理工学院，宾夕法尼亚大学，西北大学，马里兰州安德森 德克萨斯大学和哈佛大学的达娜·法伯癌研究所）。拟议的metnet中心 行政核心将由Co-MPI教授Roger Kamm领导。这笔赠款的日常管理将是 由位于麻省理工学院的中心管理员管理，他们将负责维护所有记录相对的记录 授予该奖项，并将与会员机构建立和监视协议。另外，中心 行政管理人员将得到数据经理的支持，该数据经理将在博士的共同指导下位于哈佛大学。 Franziska Michor。数据经理将坐在Metnet的资源和数据共享工作组上 将负责Metnet中心的共同开发（与中心管理员合作） 网站，关于标准元数据领域的讨论，确定是否会预先出版数据 共享元网，创建用于MetNet数据上传的SOP与不同的NCI癌 研究数据共享，并领导有关数据质量控制，交叉验证和的对话 可重复性。将成立一个外部咨询委员会（EAC），将调查人员与 与癌症转移和肿瘤微环境有关的领域专业知识。 EAC被设想为 一群高度活跃的成员参与了科学方向的Metnet中心领导层的建议 审查进度评估，研究策略和实施，领导和传播，都在 努力使中心的影响最大化。元网中心将增强翻译价值和潜力 通过参与患者倡导者的影响，其研究的影响，他们将成为EAC的成员作为审阅者，并且 评估试点项目赠款申请，并将邀请参加每月研究网络研讨会和 参加季度的COMPI会议和年度访问。促进协作和进一步的支持 多机构的沟通，广泛达到知识传播，并提供了Metnet中心 受训者的机会增强了技术和专业发展技能，行政核心 将支持虚拟的，每月的节目系列，并将提供“内部网络中心的研究交流”和50,000美元 试点项目。在AIM 1中，行政核心将监督和协调项目任务，建立 多学科项目监督并通过视频会议和面对面建立时间轴里程碑 会议。在AIM 2中，我们将开发，协调，安排和评估研究会议，研究研讨会， 以及来访的科学家计划对我们的研究任务和传播至关重要。在AIM 3中，我们将 创建Metnet Center的网站至：有关计划成就的最爱交流；充当访问 外部研究人员的询问点；作为公开可访问的研究结果的来源 通知乳腺癌患者社区；并充当所有中心的中心且可访问的存储库 生成的协议。