Clinical Translational Research Center for Neurodevelopmental Disorders

神经发育障碍临床转化研究中心

基本信息

批准号：
10085965
负责人：
Joseph Piven
金额：
$ 124.4万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-28 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10085965
关键词：
2 year old Address Affect Angelman Syndrome Applied Research Basic Science Blood Circulation Brain Caliber Center for Translational Science Activities Cerebrospinal Fluid Child Clinical Clinical Research Clinical Sciences Clinical Services Collaborations Communities Complex Data Data Science Core Development Developmental Disabilities Diagnosis Discipline Early Diagnosis Early Intervention Environment Etiology Family Fostering Fragile X Syndrome Functional disorder Funding Genetic Genomics Goals Grant Impairment Individual Infant Institutes Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study Intervention Laboratories Link Lymphatic System Meningeal Microscopy Mus Nature Neurodevelopmental Disorder Neurosciences North Carolina Participant Pathogenesis Pathogenicity Personal Satisfaction Phenotype Play Prevention Prevention strategy Proteins Rattus Registries Reporting Research Research Personnel Research Project Grants Research Support Research Training Resources Role Science Syndrome Training Translational Research United States National Institutes of Health Universities animal imaging autism spectrum disorder base behavior measurement behavioral phenotyping brain behavior collaborative environment cost effective educational atmosphere imaging facilities improved insight mouse model multidisciplinary neuroinflammation novel pre-clinical predictive marker programs response synergism targeted treatment therapy development

项目摘要

Project Summary The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmental disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 46 investigators from 13 University departments, and includes 89 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Brain and Behavior Development; (2) Autism and Related Neurodevelopmental Disorders; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores – the Clinical Translational Core, which includes the Research Participant Registry and Brain-Behavior Measurement Laboratory; the PreClinical Core, which includes the Mouse Behavioral Phenotyping Laboratory, Neuroscience Microscopy Facility, and Small Animal Imaging Facility; the Data Science Core Core; and (3) a pre-clinical/clinical research project entitled “Cerebrospinal fluid abnormalities in neurodevelopmental disorders” that proposes to examine role of CSF pathophysiology in the pathogenesis of selected neurodevelopmental disorders. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinary, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.

项目摘要北卡罗来纳大学的知识与发展障碍研究中心（IDDRC）是跨学科计划的总体目标是支持和促进与了解神经发育障碍的发病机理和治疗。 UNC IDDRC是关键新卡罗来纳州发展障碍研究所（CIDD）的组成部分，这是与智力和发展障碍（IDD）有关的临床服务，研究以及培训 UNC校园。 UNC IDDRC目前支持来自13个大学系的46名调查员，以及包括89个外部资助的研究项目。该IDDRC的基于广泛的研究计划是围绕3个主题集成：（1）大脑和行为发展；（2）自闭症及相关神经发育障碍；（3）早期检测/干预。 UNC IDDRC是一个高度合作计划的存在是由NIH资助的几项跨学科研究强调的中心/计划。本应用程序寻求支持：（1）行政核心；（2）三个研究核心 - 临床翻译核心，其中包括研究参与者注册表和脑行为测量实验室；临床前核，包括小鼠行为表型实验室，神经科学显微镜设施和小动物成像设施；数据科学核心；（3）a 临床前/临床研究项目，标题为“神经发育中的脑脊液异常疾病”提出了检查CSF病理生理学在选定发病机理中的作用的提议神经发育障碍。提出的三个研究核心提供了最先进，高质量和成本对这项综合，多学科的，与IDD相关的研究计划的有效支持。全面的，该中心对发育障碍的研究和科学培训产生了重大影响北卡罗来纳大学以及更新将使我们能够继续支持真正的特殊之处 IDD研究计划在UNC进行。